| Project/Area Number |
23659319
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Kobe Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SANO Kohei 京都大学, 医学研究科, 助教 (00546476)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 薬学 / 放射線 / 疼痛 / イメージング / 分子イメージング / 痛み / 受容体 |
|---|
| Research Abstract |
Here we confirmed the validity of peripheral benzodiazepine receptors (PBR) as a target for molecular imaging of activated microglia, as revealed by quantitative in vitro autoradiography of ^3H-labeled PBR ligand in rat brain slices. A two PBR ligands-conjugated Ga-DOTA chelate, DOTA-PK2 was designed as a multivalent PET probe of activated microglia. We successfully synthesized a^67Ga-labeled DOTA-MN2 with high radiochemical purity. These results provide useful information about the chemical design of PET probe for molecular imaging of pain.
|
