| Project/Area Number |
23659326
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
ICHIHARA Gaku 名古屋大学, 医学(系)研究科(研究院), 准教授 (90252238)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Kiyofumi 名古屋大学, 医学部附属病院, 教授 (30303639)
ICHIHARA Sahoko 三重大学, 地域イノベーション研究科, 准教授 (20378326)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | バイオマーカー / リスク評価 / ブロモプロパン / ニューロン新生 / 神経新生 / 環境化学物質 / 抑うつ / 認知機能 |
|---|
| Research Abstract |
The present study revealed that exposure to 1-bromopropane, an alternative to ozone-depleting solvents, suppressed neurogenesis in the dentate gyrus of adult rats and noradrenaline, glucocorticoid receptor (GR), brain-derived neurotropic factor (BDNF) are expected to be involved in suppression of the neurogenesis. Change in serotonin level was minimal compared to the decrease in noradrenaline level. Count of proliferative cell in the dentate gyrus, and the level of noradrenaline, GR or BDNF may be used as biomarkers for the toxicity of 1-bromopropane to the central nervous system.
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