Role of neurogenesis in mechanism of chronic or late-onset toxicity of environmental chemicals to the central nervous system

• Project/Area Number: 23659326
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene
• Research Institution: Nagoya University
• Principal Investigator: ICHIHARA Gaku 名古屋大学, 医学(系)研究科(研究院), 准教授 (90252238)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Kiyofumi 名古屋大学, 医学部附属病院, 教授 (30303639) ; ICHIHARA Sahoko 三重大学, 地域イノベーション研究科, 准教授 (20378326)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: バイオマーカー / リスク評価 / ブロモプロパン / ニューロン新生 / 神経新生 / 環境化学物質 / 抑うつ / 認知機能

Research Abstract

The present study revealed that exposure to 1-bromopropane, an alternative to ozone-depleting solvents, suppressed neurogenesis in the dentate gyrus of adult rats and noradrenaline, glucocorticoid receptor (GR), brain-derived neurotropic factor (BDNF) are expected to be involved in suppression of the neurogenesis. Change in serotonin level was minimal compared to the decrease in noradrenaline level. Count of proliferative cell in the dentate gyrus, and the level of noradrenaline, GR or BDNF may be used as biomarkers for the toxicity of 1-bromopropane to the central nervous system.

Research Products

• [Journal Article] Time course of blood parameters in printing workers with cholangiocarcinoma (2014)
  • Author(s): Kumagai S, Kurumatani N, Arimoto A, Ichihara G
  • Journal Title: Journal of Occupational Health Volume: (in press)
  • NAID: 130004694135
  • Peer Reviewed
• [Journal Article] Time course of blood parameters in printing workers with cholangiocarcinoma. (2014)
  • Author(s): Kumagai S, Kurumatani N, Arimoto A, Ichihara G
  • Journal Title: Journal of Occupational Health Volume: in press
  • NAID: 130004694135
  • Peer Reviewed
• [Journal Article] Trends in Asbestos and Non-asbestos Fibre Concentrations in the Lung Tissues of Japanese Patients with Mesothelioma (2014)
  • Author(s): Sakai K, Hisanaga N, Shibata E, Kamijima M, Ichihara G, Takeuchi Y, Nakajima T
  • Journal Title: Ann Occup Hyg Volume: 58 Pages: 103-120
  • DOI: 10.1093/annhyg/met055
  • Peer Reviewed / Open Access
• [Journal Article] Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat (2014)
  • Author(s): Chang J, Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Aoki C, Yamada Y, Ichihara G, Kato M, Ichihara S
  • Journal Title: Diabetol Metab Syndr Volume: 6(1) Issue: 1 Pages: 8-8
  • DOI: 10.1186/1758-5996-6-8
  • Peer Reviewed / Open Access
• [Journal Article] Copper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish through down-regulation of VEGF expression and induction of apoptosis (2014)
  • Author(s): J Chang, G Ichihara, Y Shimada, S Tada-Oikawa, J Kuroyanagi, B Zhang, Y Suzuki, R Sehsah, M Kato, T Kuroyanagi, B Zhang, Y Suzuki, R Sehsah, M Kato, T Tanaka, S Ichihara
  • Journal Title: Journal of Nanoscience and Nanotechnology Volume: in press
  • Peer Reviewed
• [Journal Article] Zinc oxide nanoparticles induce migration and adhesion of monocytes to endothelial cells and accelerate foam cell formation. (2014)
  • Author(s): Suzuki Y, Tada-Oikawa S, Ichihara G, Yabata M, Izuoka K, Suzuki M, Sakai K, Ichihara S.
  • Journal Title: Toxicol Appl Pharmacol Volume: in press Issue: 1 Pages: 16-25
  • DOI: 10.1016/j.taap.2014.04.010
  • Peer Reviewed
• [Journal Article] Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane (2013)
  • Author(s): Kumagai S, Ichihara G 他
  • Journal Title: Occup Environ Med Volume: (印刷中) Issue: 7 Pages: 508-510
  • DOI: 10.1136/oemed-2012-101246
  • Peer Reviewed
• [Journal Article] Effects of exposure to 1-bromopropane on astrocytes and oligodendrocytes in rat brain (2013)
  • Author(s): Mohideen SS, Ichihara S, Subramanian K, Huang Z, Naito H, Kitoh J, Ichihara G
  • Journal Title: J Occup Health Volume: 55 Pages: 29-38
  • NAID: 10031139891
  • Peer Reviewed
• [Journal Article] 楠進1-Bromopropane 曝露による中毒性神経障害の一例 (2013)
  • Author(s): 寒川真、塩山実章、鈴木秀和、上田昌美、岡伸幸、市原学、三井良之
  • Journal Title: 産業医学ジャーナル Volume: 36 Pages: 16-21
• [Journal Article] Effects of exposure to 1-bromopropane on astrocytes and oligodendrocytes in rat brain. (2013)
  • Author(s): Mohideen SS, Ichihara S, Subramanian K, Huang Z, Naito H, Kitoh J, Ichihara G
  • Journal Title: J Occup Health Volume: 55 Pages: 29-38
  • NAID: 10031139891
  • Peer Reviewed
• [Journal Article] Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome. (2013)
  • Author(s): Yamaguchi T, Kitamori K, Ichihara G, Suzuki Y, Ochiai M, Yamada Y, Tada-Oikawa S, Tsuchikura S, Yamori Y, Ichihara S.
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 40 Issue: 7 Pages: 443-448
  • DOI: 10.1111/1440-1681.12107
  • Peer Reviewed
• [Journal Article] Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time. (2013)
  • Author(s): Thang ND, Yajima I, Ohnuma S, Ohgami N, Kumasaka MY, Ichihara G. Kato M.
  • Journal Title: Environmental Toxicology Volume: - Issue: 2 Pages: 161-167
  • DOI: 10.1002/tox.21881
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Barium and Arsenic Concentrations in Well Drinking Water and in Human Body Samples and a Novel Remediation System for These Elements in Well Drinking Water. (2013)
  • Author(s): Kato M, Kumasaka MY, Ohnuma S, Furuta A, Kato Y, Shekhar HU, Kojima M, Koike Y, Dinh Thang N, Ohgami N, Ly TB, Jia X, Yetti H, Naito H, Ichihara G, Yajima I.
  • Journal Title: PLoS One Volume: -
  • Peer Reviewed
• [Journal Article] Rats with metabolic syndrome resist the protective effects of N-acetyl l-cystein against impaired spermatogenesis induced by high-phosphorus/zinc-free diet. (2013)
  • Author(s): Suzuki Y, Ichihara G, Sahabudeen SM, Kato A, Yamaguchi T, Imanaka-Yoshida K, Yoshida T, Yamada Y, Ichihara S.
  • Journal Title: Exp Toxicol Pathol Volume: 65 Issue: 7-8 Pages: 1173-1182
  • DOI: 10.1016/j.etp.2013.05.009
  • Peer Reviewed
• [Journal Article] Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. (2013)
  • Author(s): Ichihara S, Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu F, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Yokota M. 他10名
  • Journal Title: Circ Cardiovasc Genet Volume: 6 Issue: 6 Pages: 569-578
  • DOI: 10.1161/circgenetics.111.000027
  • Peer Reviewed
• [Journal Article] Dispersion method for safety research on manufactured nanomaterials. (2013)
  • Author(s): Wu W, Ichihara G, Suzuki Y, Izuoka K, Oikawa-Tada S, Chang J, Sakai K, Miyazawa K, Porter D, Castranova V, Kawaguchi M, Ichihara S.
  • Journal Title: Ind Health Volume: 52 Pages: 54-65
  • NAID: 130004483598
  • Peer Reviewed
• [Journal Article] 1-Bromopropane曝露による中毒性神経障害の一例 (2013)
  • Author(s): 寒川真、塩山実章、鈴木秀和、上田昌美、岡伸幸、市原学、三井良之、楠進
  • Journal Title: 産業医学ジャーナル Volume: 36 Pages: 16-21
• [Journal Article] Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats. (2012)
  • Author(s): L Zhang, T Nagai, K Yamada, D Ihi, S Ichihara K Subramanian.
  • Journal Title: Toxicology Volume: 304C Pages: 76-82
  • DOI: 10.1016/j.tox.2012.12.009
  • Peer Reviewed
• [Journal Article] A case of severe neurotoxicity associated with exposure to 1-bromopropane, an alternative to ozone-depleting or global-warming solvents (2012)
  • Author(s): Samukawa M, Ichihara G, Oka N, Kusunoki S
  • Journal Title: Arch Intern Med Volume: 172(16) Pages: 1257-1260
  • Peer Reviewed
• [Journal Article] Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum. (2012)
  • Author(s): Subramanian K, Mohideen SS, Suzumura A, Asai N, Murakumo Y, Takahashi M, Jin S, Zhang L, Huang Z, Ichihara S, Kitoh J, Ichihara G.
  • Journal Title: Toxicology. Volume: 302（1） Issue: 1 Pages: 18-24
  • DOI: 10.1016/j.tox.2012.07.006
  • Peer Reviewed
• [Journal Article] Proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure (2012)
  • Author(s): Huang Z, Ichihara G他6名
  • Journal Title: Toxi col Appl Pharmacol. Volume: 263(1) Issue: 1 Pages: 44-52
  • DOI: 10.1016/j.taap.2012.05.021
  • Peer Reviewed
• [Journal Article] Occupational exposure to neurotoxic substances in Asian countries - Challenges and approaches (2012)
  • Author(s): Meyer-Baron M, Ichihara G他3名
  • Journal Title: Neurotoxicology Volume: 33(4) Issue: 4 Pages: 853-861
  • DOI: 10.1016/j.neuro.2011.12.012
  • Peer Reviewed
• [Journal Article] Neurotoxicity of 1-bromopropane: Evidence from animal experiments and human studies (2012)
  • Author(s): Ichihara G, 他5名
  • Journal Title: Journal of Advanced Research Volume: 3 (2) Issue: 2 Pages: 91-98
  • DOI: 10.1016/j.jare.2011.04.005
  • Peer Reviewed
• [Journal Article] A case of severe neurotoxicity associated with exposure to 1-bromopropane, an alternative to ozone-depleting or global-warming solvents. (2012)
  • Author(s): Samukawa M, Ichihara G, Oka N, Kusunoki S.
  • Journal Title: Arch Intern Med. Volume: 172（16） Pages: 1257-1260
  • Peer Reviewed
• [Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat. (2012)
  • Author(s): Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S.
  • Journal Title: Nutr Metab (Lond). Volume: 9（1） Issue: 1 Pages: 87-87
  • DOI: 10.1186/1743-7075-9-87
  • NAID: 120006667439
  • Peer Reviewed
• [Journal Article] Effects of Exposure to 1-Bromopropane on Astrocytes and Oligodendrocytes in Rat Brain. (2012)
  • Author(s): Mohideen SS, Ichihara S, Subramanian K, Huang Z, Naito H, Kitoh J, Ichihara G.
  • Journal Title: J Occup Health. Volume: 55 Pages: 29-38
  • NAID: 10031139891
  • Peer Reviewed
• [Journal Article] Dose-dependent neurologic abnormalities in workers exposed to 1-bromopropane: authors' response. (2011)
  • Author(s): Ichihara G, 他11名
  • Journal Title: Journal of Occupational and Environmental Medicine Volume: 53 Issue: 10 Pages: 1095-1098
  • DOI: 10.1097/jom.0b013e3182300a4f
  • Peer Reviewed
• [Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis (2011)
  • Author(s): Nagai H., Okazaki Y., Chew SH., Misawa N., Yamashita Y., Akatsuka S., Ishihara T., Yamashita K., Yoshikawa Y., Yasui H., Jiang L., Ohara H., Takahashi T., Ichihara G., Kostarelos K., Miyata Y., Shinohara H., Toyokuni S.
  • Journal Title: Proceedings of the National Academy of Sciences USA Volume: 108 Issue: 49
  • DOI: 10.1073/pnas.1110013108
  • Peer Reviewed
• [Journal Article] Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane (2011)
  • Author(s): Huang Z., et al
  • Journal Title: Toxicol Appl Pharmacol Volume: 257 Issue: 1 Pages: 93-101
  • DOI: 10.1016/j.taap.2011.08.023
  • Peer Reviewed
• [Journal Article] Nakamura S.Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain (2011)
  • Author(s): Mohideen SS, Ichihara G, Ichihara S
  • Journal Title: Toxicology Volume: 285 Issue: 1-2 Pages: 67-71
  • DOI: 10.1016/j.tox.2011.04.005
  • Peer Reviewed
• [Journal Article] Pleural Plaque Profiles on the Chest Radiographs and CT Scans of Asbestos-exposed Japanese Construction Workers (2011)
  • Author(s): Elshazley M et al.
  • Journal Title: Industrial Health Volume: 49 Issue: 5 Pages: 626-633
  • DOI: 10.2486/indhealth.MS1268
  • NAID: 130004828645
  • ISSN: 0019-8366, 1880-8026
  • Peer Reviewed
• [Presentation] Effects of Exposure to 1-Bromopropane on the Level of Thyroid Hormone in Cerebrospinal Fluid of Rats (2014)
  • Author(s): L. Zhang, C. Zong1, N. Koibuchi, S. Ichihara, H. Fujita, J. Chang, J. Huang, H. Naito, M. Kato, G. Ichihara
  • Organizer: The 53rd Annual Meeting of the Society of Toxicology
  • Place of Presentation: Phoenix Convention Center, AZ, USA
• [Presentation] ラット脳脊髄液中甲状腺ホルモンレベルの変化への1BP (2014)
  • Author(s): 張 霊逸,宗 才,鯉淵典之,市原佐保子,藤田博美,常 杰,黄 晋彦,内藤久雄,市原 学
  • Organizer: 曝露の影響第13回分子予防環境医学研究会
  • Place of Presentation: 和歌山県民文化会館、和歌山市
• [Presentation] ラット脳脊髄液中甲状腺ホルモンレベルの変化への1BP曝露の影響 (2014)
  • Author(s): 張 霊逸，宗 才，鯉淵典之，市原佐保子，藤田博美，常 杰，黄 晋彦，内藤久雄，市原 学
  • Organizer: 第13回分子予防環境医学研究会
  • Place of Presentation: 和歌山県民文化会館、和歌山市
• [Presentation] Effects of pharyngeal aspiration exposure to zinc oxide nanoparticles on pulmonary fibrosis induced by bleomycin in mice (2014)
  • Author(s): Wenting Wu, Gaku Ichihara, Saeko Tada-Oikawa, Yuka Suzuki, Jie Chang, Naozumi Hashimoto, Yoshinori Hasegawa, Corina Gabazza, Esteban Gabazza, Sahoko Ichihara
  • Organizer: 第13回分子予防環境医学研究会
  • Place of Presentation: 和歌山県民文化会館、和歌山市
• [Presentation] 単層、二層カーボンナノチューブによるアテローム性動脈硬化症への影響とその作用機序の検討 (2014)
  • Author(s): 鈴木悠加，市原 学，宗 才，及川(多田)佐枝子，出岡 淑，市原佐保子
  • Organizer: 第13回分子予防環境医学研究会
  • Place of Presentation: 和歌山県民文化会館、和歌山市
• [Presentation] Fenofibrate Reduces Cardiac Fibrosis Due to the Reduction of the DNA Binding Activity of the Hypoxia-Inducible Factor-1/Aryl Hydrocarbon Receptor Nuclear Translocator Complex (2014)
  • Author(s): S. Ichihara, Y. Suzuki, S. Tada-Oikawa and G. Ichihara
  • Organizer: The 53rd Annual Meeting of the Society of Toxicology
  • Place of Presentation: Phoenix Convention Center, AZ, USA
• [Presentation] Zinc Oxide Nanoparticles Induce Cytotoxicity in Human Endothelial Colony-Forming Cells (2014)
  • Author(s): Y. Suzuki, S. Tada-Oikawa1, G. Ichihara, K. Izuoka and S. Ichihara.
  • Organizer: The 53rd Annual Meeting of the Society of Toxicology
  • Place of Presentation: Phoenix Convention Center, AZ, USA
• [Presentation] The Effects of Pharyngeal Aspiration-Exposure to Zinc Oxide Nanoparticles on Pulmonary Fibrosis Induced Bleomycin in Miceby (2014)
  • Author(s): W. Wu, G. Ichihara, S. Tada-Oikawa, Y. Suzuki, J. Chang,N. Hashimoto, Y. Hasegawa, D. W. Porter, V. Castranova, C. Gabazza, E. Gabazza, S. Ichihara
  • Organizer: The 53rd Annual Meeting of the Society of Toxicology
  • Place of Presentation: Phoenix Convention Center, AZ, USA
• [Presentation] The Effects of Metal Oxide Nanoparticles on Angiogenesis in Transgenic Zebrafish (2014)
  • Author(s): J. Chang, G. Ichihara, Y. Shimada, S. Tada-Oikawa, Y. Suzuki, R. Sehsah, M. Kato, T. Tanaka, S. Ichihara
  • Organizer: The 53rd Annual Meeting of the Society of Toxicology
  • Place of Presentation: Phoenix Convention Center, AZ, USA
• [Presentation] Effects of Short- and Long-Term Exposure to 1-Bromopropane on Neurogenesis in Adult Rats (2013)
  • Author(s): L. Zhang, T. Nagai, K. Yamada, D. Ibi, S. Ichihara, K. Subramanian, Z. Huang,S. Sheik Mohideen, H. Naito, G. Ichihara
  • Place of Presentation: SanAntonio,USA
• [Presentation] オフセット印刷労働者に多発した胆管癌の原因物質解明のための動物実験 (2013)
  • Author(s): 市原学
  • Organizer: 第86回日本産業衛生学会
  • Place of Presentation: ひめぎんホール、愛媛・松山市
• [Presentation] ラットにおける1-BPの亜急性と亜慢性吸入暴露によって神経新生への影響 (2013)
  • Author(s): 張霊逸、永井拓、山田清文、衣斐大祐、市原佐保子、サブラマニアンカビアラサン、黄振烈、モヒデインサハブディン、内藤久雄、市原学
  • Organizer: 第86回日本産業衛生学会
  • Place of Presentation: ひめぎんホール、愛媛・松山市
• [Presentation] ゼブラフィッシュを用いたナノ酸化金属の血管新生に対する影響の検討 (2013)
  • Author(s): 常杰、市原学、及川（多田）佐枝子、島田康人、田中利男、市原佐保子
  • Organizer: 第86回日本産業衛生学会
  • Place of Presentation: ひめぎんホール、愛媛・松山市
• [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響 (2013)
  • Author(s): 呉文亭、 市原学、及川(多田)佐枝子、 鈴木悠加、常杰、 橋本直純、 長谷川好規、ガバザコリナ、 ガバザエステバン、市原佐保子
  • Organizer: 第86回日本産業衛生学会
  • Place of Presentation: ひめぎんホール、愛媛・松山市
• [Presentation] ナノ酸化亜鉛が，ブレオマイシンによって誘導されるマウスの肺線維症に与える影響 (2013)
  • Author(s): 呉文亭、 市原学、及川(多田)佐枝子、 鈴木悠加、常杰、 橋本直純、 長谷川好規、ガバザコリナ、 ガバザエステバン、市原佐保子
  • Organizer: 第40回日本毒性学会学術年会
  • Place of Presentation: 幕張メッセ国際会議場、千葉市
• [Presentation] ゼブラフィッシュを用いたナノ酸化金属の血管新生に対する影響の検討 (2013)
  • Author(s): 常 杰，市原 学，及川(多田) 佐枝子，島田 康人，田中 利男，市原 佐保子
  • Organizer: 第40回日本毒性学会学術年会
  • Place of Presentation: 幕張メッセ国際会議場、千葉市
• [Presentation] 工業ナノマテリアルの職業暴露評価における課題 (2013)
  • Author(s): 市原 学，小林 隆弘，藤谷 雄二，尾村 誠一，市原 佐保子
  • Organizer: シンポジウム「ナノマテリアルの評価手法開発における今後の課題」 第40回日本毒性学会学術年会
  • Place of Presentation: 幕張メッセ国際会議場、千葉市
• [Presentation] The Effect of Pharyngeal Aspiration Exposureto Zinc Oxide Nanoparticles on Pulmonary Fibrosis Induced by Bleomycin in Mice (2013)
  • Author(s): Wu W,Gaku Ichihara,Saeko tada-Oikawa,Yuka Suzuki,Jie Chang,Naozumi Hashimoto,Yoshimori Hasegawa,Corina Gabazza,Esteban Gabazza and Sahoko Ichihara
  • Organizer: the XIII International Congress of Toxicology
  • Place of Presentation: Coex,Seoul,Korea
• [Presentation] Occupational and environmental health in nanotechnology (2013)
  • Author(s): Ichihara G
  • Organizer: Symposium "Ecological and Health Impact of Nanomaterials and Nanotechnology" in the 7th International Conference on Materials for Advanced Technologies（ICMAT2013）
  • Place of Presentation: Suntec,Singapore
  • Invited
• [Presentation] The effects of pharyngeal aspiration exposure to zinc oxide nanoparticles on pulmonary fibrosis induced by bleomycin in mice (2013)
  • Author(s): Wenting Wu,Gaku Ichihara,Saeko tada-Oikawa,Yuka Suzuki,Jie Chang,Naozumi Hashimoto,Yoshimori Hasegawa,Corina Gabazza,Esteban Gabazza and Sahoko Ichihara
  • Organizer: 日本産業衛生学会 第41回 産業中毒・生物学的モニタリング研究会
  • Place of Presentation: 大阪市立大学医学部校舎、大阪市
• [Presentation] Effects of exposure to 1-bromopropane on the level of thyroid hormone in cerebrospinal fluid of rats (2013)
  • Author(s): 張 霊逸、宗 才、鯉淵 典之、市原 佐保子、藤田 博美、常 杰、黄 晋彦、内藤 久雄、市原 学
  • Organizer: 日本産業衛生学会 第41回 産業中毒・生物学的モニタリング研究会
  • Place of Presentation: 大阪市立大学医学部校舎、大阪市
• [Presentation] NanOEHS Overview (2013)
  • Author(s): Gaku Ichihara, Yoshinori Hasegawa
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Critical factors in multi-walled carbon nanotubes for mesothelial carcinogenesis (2013)
  • Author(s): Shinya Toyokuni, Hirotaka Nagai, Yasumasa Okazaki, Shan Hwu Chew, Shinya Akatsuka, Li Jiang, Gaku Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Zinc oxide particles induced migration and adhesion of monocytes and increased macrophage cholesterol (2013)
  • Author(s): Yuka Suzuki, Saeko Tada-Oikawa, Gaku Ichihara, Kiyoshi Sakai, Masayuki Yabata, Kiyora Izuoka, Sahoko Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Effects on Respiratory and Cardiovascular Systems in Workers Handling Titanium Dioxide Particles (2013)
  • Author(s): Sahoko Ichihara, Weihua Li, Seiichi Omura, Yuji Fujitani, Ying Liu, Qiangyi Wang, Yusuke Hiraku, Naomi Hisanaga, Xuncheng Ding, Takahiro Kobayashi, Gaku Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Dispersion method for safety research on manufactured nanomaterials (2013)
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kun’ichi Miyazawa, Dale Porter, Vincent Castranova, Masami Kawaguchi , Sahoko Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] The effects of exposure to zinc oxide nanoparticles on bleomycin-induced pulmonary fibrosis in mice (2013)
  • Author(s): Wenting Wu, Gaku Ichihara, Saeko Tada-Oikawa, Yuka Suzuki, Jie Chang, Naozumi Hashimoto, Yoshinori Hasegawa, Corina Gabazza, Esteban Gabazza, Sahoko Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish (2013)
  • Author(s): Jie Chang, Gaku Ichihara, Saeko Tada-Oikawa, Kiyora Izuoka, Toshio Tanaka, Yasuhito Shimada, Sahoko Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Involvement of Nrf-2 in ZnO NP-induced pulmonary inflammation (2013)
  • Author(s): Radwa Ibrahim Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Yoshinori Hasegawa, Ken Ito, Masayuki Yamamoto, Emily Kamel, Gaku Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Single-wall or double-wall carbon nanotubes induce atherosclerosis progression in ApoE null mice (2013)
  • Author(s): Yuka Suzuki, Gaku Ichihara, Yuka Suzuki , Kiyora Izuoka, Kiyoshi Sakai, Sahoko Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Zinc oxide nanoparticles induce cytotoxicity and apoptosis in human endothelial colony-forming cells (2013)
  • Author(s): Saeko Tada-Oikawa, Gaku Ichihara, Yuka Suzuki , Kiyora Izuoka, Sahoko Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Cytotoxicity induced by nano-sized TiO2 in human monocytic leukemia cells and colon cancer cells (2013)
  • Author(s): Saeko Tada-Oikawa, Gaku Ichihara, Yuka Suzuki , Kiyora Izuoka, Sahoko Ichihara
  • Organizer: The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6（第6回国際ナノテクノロジー労働環境衛生シンポジウム）
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] Cardiovascular Effects of Manufactured Nanomaterials (2013)
  • Author(s): S. Ichihara, Y. Suzuki, S. Tada-Oikawa, K. Izuoka, C. Zong, G. Ichihara
  • Organizer: 第23回日本MRS年次大会
  • Place of Presentation: 横浜開港記念会館、横浜市
  • Invited
• [Presentation] ラット脳脊髄液中甲状腺ホルモンレベルの変化への1BP曝露の影響 (2013)
  • Author(s): 張 霊逸、宗 才、鯉淵 典之、市原 佐保子、藤田 博美、常 杰、黄 晋彦、内藤 久雄、市原 学
  • Organizer: 環境ホルモン学会第16回研究発表会
  • Place of Presentation: 東京大学山上会館、東京都文京区
• [Presentation] Effects of sub-acute and sub-chronic inhalation exposure to 1-bromopropane on neurogenesis in adult rats (2013)
  • Author(s): Lingyi Zhang, Taku Nagai, Kiyofumi Yamada, Daisuke Ibi, Sahoko Ichihara, Kaviarasan Suburamanian, Zhenlie Huang, Sahabudeen Sheik Mohideen, Hisao Naito,Gaku Ichihara
  • Organizer: 第12回分子予防環境医学研究会大会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（つくば市）
• [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響 (2013)
  • Author(s): 呉ウェンティン, 市原学, 及川(多田)佐枝子, 鈴木悠加, 常杰, 橋本直純, 長谷川好規, ガバザコリナ, ガバザエステバン, 市原佐保子
  • Organizer: 第12回分子予防環境医学研究会大会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（つくば市）
• [Presentation] ナノ酸化亜鉛による単球遊走作用とマクロファージのコレステロール取り込み作用への影響 (2013)
  • Author(s): 鈴木悠加, 及川(多田)佐枝子, 出岡淑, 市原学, 市原佐保子
  • Organizer: 第12回分子予防環境医学研究会大会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（つくば市）
• [Presentation] The effects of metal oxide nanoparticles on angiogenesis in transgenic zebrafish (2013)
  • Author(s): 常杰, 市原学, 及川(多田)佐枝子, 島田康人, 田中利男, 市原佐保子
  • Organizer: 第12回分子予防環境医学研究会大会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（つくば市）
• [Presentation] 全ゲノム罹患同胞対連鎖解析による新規若年発症心筋梗塞感受性遺伝子の同定 (2013)
  • Author(s): 市原佐保子, 山本健, 市原学, 井ノ上逸朗, 横田充弘
  • Organizer: 第12回分子予防環境医学研究会大会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（つくば市）
• [Presentation] Neurotoxicity of 1-bromopropane: Review and perspective (2013)
  • Author(s): Gaku Ichihara
  • Organizer: Workshop on 1-bromopropane toxicity in Shanghai
  • Place of Presentation: 上海、Fudan University School of Public Health（中国）
• [Presentation] Effects of Short- and Long-Term Exposure to 1-Bromopropane on Neurogenesis in Adult Rats. (2013)
  • Author(s): L. Zhang, T. Nagai, K. Yamada, D. Ibi, S. Ichihara, K. Subramanian, Z. Huang, S. Sheik Mohideen, H. Naito, and G. Ichihara.
  • Organizer: The 52th Annual Meeting of the Society of Toxicology
  • Place of Presentation: SanAntonio,USA
• [Presentation] Zinc Oxide Particles Induced Migration of Monocytes and Increased Macrophage Cholesterol Uptake. (2013)
  • Author(s): Y. Suzuki, S. Tada-Oikawa, G. Ichihara, and S. Ichihara.
  • Organizer: The 52th Annual Meeting of the Society of Toxicology
  • Place of Presentation: SanAntonio,USA
• [Presentation] 全ゲノム罹患同胞対連鎖解析による新規若年発症心筋梗塞感受性遺伝子の同定 (2013)
  • Author(s): 市原佐保子、山本健、浅野展行、中杤昌弘、市原学、松原達昭、井ノ上逸朗、横田充弘
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市（金沢大学 鶴間・宝町キャンパス）
• [Presentation] ナノ酸化亜鉛によるマクロファージの変性LDL取り込み作用への影響 (2013)
  • Author(s): 及川(多田)佐枝子、鈴木悠加、出岡淑,、市原学、市原佐保子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市（金沢大学 鶴間・宝町キャンパス）
• [Presentation] ナノ酸化亜鉛による血管内皮障害への影響 (2013)
  • Author(s): 鈴木悠加、及川(多田)佐枝子、出岡淑,、市原学、市原佐保子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市（金沢大学 鶴間・宝町キャンパス）
• [Presentation] ナノ酸化亜鉛が、ブレオマイシンによって誘導されるマウスの肺線維症に与える影響 (2013)
  • Author(s): 呉ウェンティン、 市原学、及川(多田)佐枝子、 鈴木悠加、常杰、 橋本直純、 長谷川好規、 ガバザコリナ、 ガバザエステバン、市原佐保子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市（金沢大学 鶴間・宝町キャンパス）
• [Presentation] ゼブラフィッシュを用いたナノ酸化金属の血管新生に対する影響の検討 (2013)
  • Author(s): 常杰、市原学、及川（多田）佐枝子、出岡淑、島田康人、田中利男、市原佐保子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市（金沢大学 鶴間・宝町キャンパス）
• [Presentation] 1BP亜急性および慢性吸入曝露によるラット脳での神経新生への影響 (2013)
  • Author(s): 張霊逸,永井拓,山田清文,衣斐大祐市原佐保子,スブラマニアンカビアラサン,黄振烈,シェイクモヒディーンサハブディン,内藤久雄,市原学
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢市（金沢大学 鶴間・宝町キャンパス）
• [Presentation] 工業ナノマテリアルのリスク評価と労働環境衛生学 (2013)
  • Author(s): 市原学
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Invited
• [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現への1-ブロモプロパン曝露の影響 (2012)
  • Author(s): 張霊逸,永井拓,山田清文,市原佐保子,スブラマニアンカビアラサン,黄振烈,シェイクモヒディーンサハブディーン,内藤久雄,市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 中皮腫患者の肺内石綿の濃度とその繊維サイズ (2012)
  • Author(s): 酒井潔、久永直見、柴田英治、上島通浩、市原学、那須民江
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 1－ブロモプロパンはF344ラットの海馬においてTriosephosphate Isomeraseのカルボニル化とAdvanced Glycation End-Productsを増加させる (2012)
  • Author(s): 黄振烈、市原佐保子、及川伸二、常杰、張霊逸、Subramanian Kaviarasan、Sheik Mohideen Sahabudeen、市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 1－ブロモプロパン曝露のラット小脳におけるグリア、ミエリンに対する影響 (2012)
  • Author(s): Sheik Mohideen Sahabudeen、市原佐、Subramanian Kaviarasan、黄振烈、鬼頭純三、市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 工業ナノマテリアル安全性研究のための分散法の検討 (2012)
  • Author(s): 呉文亭、市原佐保子、常杰、 及川（多田）佐枝子、太田有香、矢端将行、市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 二酸化チタンナノ粒子による細胞毒性作用および炎症反応誘導作用の解析 (2012)
  • Author(s): 及川（多田）佐枝子、呉ウェンティン、市原学、常杰、矢端将行、及川伸二、市原佐保子
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] ナノサイズ酸化チタンの心肺機能への影響に関する調査研究 (2012)
  • Author(s): 市原佐保子、小林隆弘、李衛華、尾村誠一、平工雄介、久永直見、丁訓誠、市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] シンポジウム「ナノマテリアルと労働環境衛生」内での報告「欧米のナノマテリアル吸入曝露試験、労働衛生の取り組み」 (2012)
  • Author(s): 市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 産業化学物質による神経毒性評価－最新の動物実験のヒトにおける毒性評価への応用と可能性－（産業中毒・生物的モニタリング研究会企画） (2012)
  • Author(s): 市原学
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] Oxidative modification leads to the left ventricular dysfunction in cardiomyopathy (2012)
  • Author(s): Sahoko Ichihara, Jie Chang, Saeko Tada-Oikawa, Chisa Ando, Kentaro Kuzuya, Gaku Ichihara, Shinji Oikawa
  • Organizer: Eurotox 2012 (48th congress of European Societies of Toxicology)
  • Place of Presentation: Stockholm,Sweden
• [Presentation] NAC prevents high-P/Zn-free diet-induced peripheral nervous dysfunction (2012)
  • Author(s): Sahoko Ichihara, Yuka Suzuki, Ai Kato, Takahiro Yamaguchi, Gaku Ichihara
  • Organizer: Eurotox 2012 (48th congress of European Societies of Toxicology)
  • Place of Presentation: Stockholm,Sweden
• [Presentation] Susceptibility to 1-bromopropane exposure and gene expression in two rat strains (2012)
  • Author(s): Gaku Ichihara, Fen Huang, Sahoko Ichihiara, Emiko Kitagawa, Satomi Mizugami, Hitoshi Iwahashi, Iida Mari, Kitoh Junzho
  • Organizer: Eurotox 2012 (48th congress of European Societies of Toxicology)
  • Place of Presentation: Stockholm,Sweden
• [Presentation] 1-bromopropane increases triosephosphate isomerase carbonylation and advanced glycation end-products in the hippocampus of F344 rats (2012)
  • Author(s): Zhenlie HUANG, Sahoko ICHIHARA, Shinji OIKAWA, Jie CHANG, Lingyi ZHANG, Kaviarasan SUBRAMANIAN, Sahabudeen Sheik MOHIDEEN, Gaku ICHIHARA
  • Organizer: The 6th International Congress of Asian Society of Toxicology
  • Place of Presentation: 仙台国際センター（仙台市）
• [Presentation] Exposure to 1-bromopropane decreases neuron proliferation in adult rat dentate gyrus (2012)
  • Author(s): Lingyi ZHANG, Taku NAGAI, Kiyofumi YAMADA, Sahoko ICHIHARA, Kaviarasan SUBURAMANIAN, Zhenlie HUANG, Sahabudeen Sheik MOHIDEEN, Hisao NAITO, Gaku ICHIHARA
  • Organizer: The 6th International Congress of Asian Society of Toxicology
  • Place of Presentation: 仙台国際センター（仙台市）
• [Presentation] Dispersion method for in vivo safety researches on manufactured nanomaterials (2012)
  • Author(s): Wenting WU, Sahoko ICHIHARA, Saeko TADA-OIKAWA, Jie CHANG, Gaku ICHIHARA
  • Organizer: The 6th International Congress of Asian Society of Toxicology
  • Place of Presentation: 仙台国際センター（仙台市）
• [Presentation] Occupational and Environmental Health in Nanotechnology (2012)
  • Author(s): Gaku Ichihara,Takahiro Kobayashi, Kun'ichi Miyazawa, Naomi Hisanaga,Kiyoshi Sakai,Eiji Shibata,Ilje Yu,Shinya Toyokuni,Yoshinori Hasegawa, Sahoko Ichihara
  • Organizer: NANO KOREA 2012 symposium:The 10th International Nanotech Symposium
  • Place of Presentation: Coex,Seoul,Korea
• [Presentation] ANF Technical Seminars on "Nanosafety" Occupational and environmental health in nanotechnology (2012)
  • Author(s): Tsung Tsan SU(Chair),Paul WRIGHT,Gaku ICHIHARA,Sang-Hee SUH,Tsung Tsan SU
  • Organizer: Asia Nano Forum 9th Summit Meeting (ANFoS2012)
  • Place of Presentation: Bangkok,Thailand
• [Presentation] Dispersion method for safety research on manufactured nanomaterials (2012)
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
  • Organizer: The 6th International Conference on Nanotoxicology
  • Place of Presentation: Beijin,China
• [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized metal oxide nanoparticles in human monocytic leukemia cells. (2012)
  • Author(s): Sahoko Ichihara, Saeko Tada-Oikawa, Masayuki Yabata, Kiyora Izuoka, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
  • Organizer: The 6th International Conference on Nanotoxicology
  • Place of Presentation: Beijin,China
• [Presentation] Exposure assessment of manufactured nanomaterials and occupational health survey (2012)
  • Author(s): Gaku ICHIHARA
  • Organizer: IUMRS-ICEM2012
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Invited
• [Presentation] Cytotoxicity induced by nano-sized titanium dioxide in human monocytic leukemia cells (THP-1) (2012)
  • Author(s): Saeko Tada-Oikawa, Sahoko Ichihara,, Kiyora Izuoka,, Masayuki Yabata, Jie Chang, Yuka Ota, Wenting Wu, Gaku Ichihara
  • Organizer: IUMRS-ICEM2012
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials (2012)
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
  • Organizer: IUMRS-ICEM2012
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Cytotoxicity and inflammatory responses induced by nano-sized titanium dioxide in human monocytic leukemia cells (2012)
  • Author(s): Tada-Oikawa S, Ichihara S, Yabata M, Chang J, Ota Y, Wu W, Ichihara G
  • Organizer: SENN2012 - International Congress on Safety of Engineered Nanoparticles and Nanotechnologies
  • Place of Presentation: Helsinki, Finland
• [Presentation] Effects of short- and long-term exposure to 1-bromopropane on neurogenesis in adult rats. (2012)
  • Author(s): Lingyi Zhang,Taku Nagai, Kiyofumi Yamada, Daisuke Ibi, Sahoko Ichihara,Kaviarasan Suburamanian, Zhenlie Huang, Sahabudeen Sheik Mohideen,Hisao Naito, and Gaku Ichihara
  • Organizer: 日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
  • Place of Presentation: マホロバマインズ三浦、神奈川
• [Presentation] メタボリック症候群の標的分子マーカーの探索 (2012)
  • Author(s): 常 杰、 市原 学、 及川伸二、 堀田康弘、 加藤智英子、 市原佐保子
  • Organizer: 日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
  • Place of Presentation: マホロバマインズ三浦、神奈川
• [Presentation] オフセット校正印刷労働者に多発する肝内・肝外胆管癌 (2012)
  • Author(s): 熊谷信二、 車谷典男、 市原 学
  • Organizer: 日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
  • Place of Presentation: マホロバマインズ三浦、神奈川
• [Presentation] Dispersion method for safety research on manufactured nanomaterials. (2012)
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
  • Organizer: 日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
  • Place of Presentation: マホロバマインズ三浦、神奈川
• [Presentation] ブロモプロパンの神経毒性 (2012)
  • Author(s): 市原学
  • Organizer: 第60回日本職業・災害医学会学術大会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Invited
• [Presentation] Proteomic Identification of Carbonylated Proteins in F344 Rat Hippocampus after 1-Bromopropane Exposure. (2012)
  • Author(s): Huang Z et al.
  • Organizer: The 51th Annual Meeting of the Society of Toxicology
  • Place of Presentation: 米国 サンフランシスコ
• [Presentation] ト研究と動物実験による産業化学物質の毒性解明 (2012)
  • Author(s): 市原学ほか
  • Organizer: 第84回日本産業衛生学会イブニングシンポジウム(招待講演)
  • Place of Presentation: 東京、ニューピアホール、ホテルアジュール竹芝、東京都立産業貿易センター浜松町館
• [Presentation] １－ブロモプロパンに曝露されたラットにおける脳海馬蛋白のプロテオミクス解析 (2012)
  • Author(s): 黄振烈ほか
  • Organizer: 第84回日本産業衛生学会
  • Place of Presentation: 東京、ニューピアホール、ホテルアジュール竹芝、東京都立産業貿易センター浜松町館
• [Presentation] １－ブロモプロパン曝露によるラット脳のミエリン化、アストロサイト活性化への影響 (2012)
  • Author(s): シェイク モヒディーン ザハブデーンほか
  • Organizer: 第84回日本産業衛生学会
  • Place of Presentation: 東京、ニューピアホール、ホテルアジュール竹芝、東京都立産業貿易センター浜松町館
• [Presentation] Proteomic Identification of Carbonylated Proteins in F344 Rat Hippocampus after 1-Bromopropane Exposure (2012)
  • Author(s): 黄振烈ほか
  • Organizer: 第11回分子予防環境医学研究会大会
  • Place of Presentation: 倉敷、倉敷市民会館
• [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現における1-ブロモプロパン曝露の影響 (2012)
  • Author(s): 張霊逸ほか
  • Organizer: 第11回分子予防環境医学研究会大会
  • Place of Presentation: 倉敷、倉敷市民会館
• [Presentation] Exposure to 1-bromopropane induces activation of astrocyte and degeneration of neuronal cells in rat cerebellum (2012)
  • Author(s): シェイクモヒディーン サハブディーンほか
  • Organizer: 第11回分子予防環境医学研究会大会
  • Place of Presentation: 倉敷、倉敷市民会館
• [Presentation] 高血糖状態における血小板リン酸化タンパク質の同定 (2012)
  • Author(s): 紅林真理恵ほか
  • Organizer: 第11回分子予防環境医学研究会大会
  • Place of Presentation: 倉敷、倉敷市民会館
• [Presentation] ラット脳内モノアミンレベルと海馬神経栄養因子の発現への1-ブロモプロパン曝露の影響 (2012)
  • Author(s): 張霊逸ほか
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都、京都大学
• [Presentation] １－ブロモプロパン曝露のラット小脳におけるグリア、ミエリンに対する影響 (2012)
  • Author(s): シェイクモヒディーン サハブディーンほか
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都、京都大学
• [Presentation] 二酸化チタンナノ粒子による細胞毒性作用の解析 (2012)
  • Author(s): 及川（多田）佐枝子ほか
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都、京都大学
• [Presentation] メタボリック症候群の標的分子マーカーの検索 (2012)
  • Author(s): 常杰ほか
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都、京都大学
• [Presentation] EHS researches on manufactured nanomaterials in Japan. (2011)
  • Author(s): Ichihara G
  • Organizer: The Seventh International Nanotechnology Conference on Communication and Cooperation (INC7)(招待講演)
  • Place of Presentation: 米国 オーバニー
• [Presentation] Neurotoxicity of 1-bromopropane, an alternative to ozone-depleting solvents. (2011)
  • Author(s): Ichihara G. et al.
  • Organizer: The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
  • Place of Presentation: 中国 西安
• [Presentation] Effects of 1-bromopropane exposure on monoamine levels in brain and hippocampal brain-derived neurotrophic factor expression in rats. (2011)
  • Author(s): Lingyi Z et al.
  • Organizer: The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
  • Place of Presentation: 中国 西安
• [Presentation] Proteomic analysis of hippocampal protein in f344 rats exposed to 1-bromopropane. (2011)
  • Author(s): Huang Z et al.
  • Organizer: The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
  • Place of Presentation: 中国 西安
• [Presentation] Effects of 1-bromopropane exposure on myelination and glia in rat brain. (2011)
  • Author(s): Mohideen SS et al.
  • Organizer: The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
  • Place of Presentation: 中国 西安
• [Presentation] Central nerve system toxicity of 1-bromopropane: an oxidative stress hypothesis. (2011)
  • Author(s): Subramanian K et al.
  • Organizer: The 13th International Neurotoxicology Association Meeting & 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
  • Place of Presentation: 中国 西安
• [Presentation] Occupational health Survey on workers handling titanium dioxide. (2011)
  • Author(s): Ichihara S. et al.
  • Organizer: The 5th International Symposium on Nanotechnology, Occupational and Environmental Health
  • Place of Presentation: 米国 ボストン
• [Presentation] Occupational health Survey on workers handling titanium dioxide. (2011)
  • Author(s): Ichihara S. et al.
  • Organizer: The 48th Congress of the European Societies of Toxicology
  • Place of Presentation: フランス、パリ
• [Presentation] Hyperphosphatemia and hypozincemia aggravated hypertension and cardiac dysfunction in SHR/NDmcr-cp, a model of metabolic syndrome. (2011)
  • Author(s): Suzuki Y. et al.
  • Organizer: The 84th Scientific Sessions of American Heart Association
  • Place of Presentation: 米国、オーランド
• [Presentation] Oxidative modification of the proteins related to ATP synthesis leads to the left ventricular dysfunction in cardiomyopathy. (2011)
  • Author(s): Ichihara S. et al.
  • Organizer: The 84th Scientific Sessions of American Heart Association
  • Place of Presentation: 米国、オーランド
• [Presentation] Central nervous system toxicity of 1-bromopropane: an oxidative stress hypothesis (2011)
  • Author(s): Subramanian K et al.
  • Organizer: The 48th Congress of the European Societies of Toxicology
  • Place of Presentation: フランス、パリ
• [Presentation] ナノマテリアルの安全性
  • Author(s): 市原学
  • Organizer: 「科学物質・環境規制ワークショップ2013」第5回 ナノマテリアル 安全性と規制化動向
  • Place of Presentation: 北とぴあ、東京・王子市
  • Invited
• [Presentation] カーボンナノ材料の安全性とリスク管理について
  • Author(s): 市原 学
  • Organizer: 平成25年度第4回カーボンナノ材料研究会
  • Place of Presentation: 一般財団法人大阪科学技術センタービル、大阪市
  • Invited
• [Presentation] 工業ナノマテリアルの安全性と労働環境衛生学
  • Author(s): 市原学
  • Organizer: 化学物質・環境規制ワークショップ第一期2012
  • Place of Presentation: 大田区産業プラザ、東京・蒲田
  • Invited
• [Presentation] Dispersion method for safety research on manufactured nanomaterials
  • Author(s): Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Sahoko Ichihara
  • Organizer: Workshop on the risk management of engineered nanomaterials（工業用ナノマテリアルのリスク管理研究会）
  • Place of Presentation: NIMS、つくば
• [Presentation] 中皮腫患者の肺内石綿・非石綿繊維量とその表面積
  • Author(s): 酒井潔、久永直見、柴田英治、上島通浩、内藤久雄、市原学、那須民江
  • Organizer: 日本産業衛生学会平成24年度東海地方会
  • Place of Presentation: じゅうろくプラザ, 岐阜
• [Presentation] 建設業従事者における石綿曝露職歴、胸膜肥厚斑、肺内石綿･非石綿濃度の関係
  • Author(s): 久永直見、酒井潔、柴田英治、鈴木隆佳、内藤久雄、上島通浩、市原学
  • Organizer: 日本産業衛生学会平成24年度東海地方会
  • Place of Presentation: じゅうろくプラザ, 岐阜
• [Presentation] Effects of sub-acute and sub-chronic inhalation exposure to 1-bromopropane on neurogenesis in adult rats.
  • Author(s): Lingyi Zhang, Taku Nagai, Kiyofumi Yamada, Daisuke Ibi, Sahoko Ichihara, Kaviarasan Suburamanian, Zhenlie Huang, Sahabudeen Sheik Mohideen, Hisao Naito, Gaku Ichihara
  • Organizer: 日本産業衛生学会 産業神経・行動学研究会 第24回研究会
  • Place of Presentation: 東京女子医科大学医学部中央校舎5階（東京）
• [Book] 生殖次世代影響 産業安全保健ハンドブック (2013)
  • Author(s): 市原学、 小木孝
  • Total Pages: 1332
  • Publisher: 労働科学研究所
• [Book] 12 化学的健康障害要因とその対策-33.感作性物質34.生殖毒性物質. 産業保健マニュアル (2013)
  • Author(s): 市原学、和田攻、森 晃爾
  • Total Pages: 416
  • Publisher: 南山堂. 改訂6版
• [Book] 産業保健マニュアル (2013)
  • Author(s): 市原 学、和田攻、森 晃爾
  • Total Pages: 1332
  • Publisher: 南山堂
• [Book] 産業安全保健ハンドブック (2013)
  • Author(s): 市原 学、小木和孝
  • Total Pages: 416
  • Publisher: 労働科学研究所
• [Book] 産業安全保健ハンドブック 5.44生殖次世代影響 (2012)
  • Author(s): 市原学
  • Publisher: 労働科学研究所
• [Book] 産業安全保健ハンドブック 5.44生殖次世代影響 (2012)
  • Author(s): 市原 学
  • Publisher: 労働科学研究所
• [Book] 「カーボンナノチューブ・グラフェンハンドブック」 (2011)
  • Author(s): 市原 学
  • Total Pages: 368
  • Publisher: コロナ社
• [Book] 篠原久典監修「ナノカーボンの応用と実用化－フラーレン、ナノチューブ、グラフェンを中心に－」 (2011)
  • Author(s): 市原 学
  • Total Pages: 302
  • Publisher: シーエムシー