Roles of microRNA in inflammation-related carcinogenesis and its possibility for use as a biomarker
| Project/Area Number |
23659327
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
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| Co-Investigator(Kenkyū-buntansha) |
MIDORIKAWA Kaoru 三重大学, 大学院・医学系研究科, リサーチアソシエイト (20393366)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / 上咽頭癌 / microRNA / ターゲット遺伝子 / バイオマーカー / Epstein-Barrウィルス / 発がん機構 / In silico 解析 / microRNA機能解析 / Epstein-Barr ウィルス / DNAメチル化 / マイクロアレイ解析 / 次世代シークエンサー |
|---|
| Research Abstract |
Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is one of the inflammation-associated cancers. To explore the mechanisms of NPC development and certain biomarkers for screening, a microarray profiling survey was performed to reveal the expression patterns of microRNAs across primary tumors (NPC) and normal nasopharyngeal epithelia (NNE). Quantitative real-time PCR confirmed that expression levels of the microRNAs were significantly different between NPC and NNE tissues. Several microRNAs also have significant differences in plasma samples. Up- and down-regulated microRNAs may play a role in NPC development and there is a possibility to use as biomarkers and novel targets for NPC treatment.
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Report
(3 results)
Research Products
(82 results)
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[Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression2012
Author(s)
Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, . 2012:623019. (2012). 査読有Murata M, Kawanishi S
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Journal Title
Biochem Biophys Res Commun
Volume: 421(2)
Pages: 280-5
Related Report
Peer Reviewed
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[Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma2012
Author(s)
Thanan R, Oikawa S, Yongvanit P, Hiraku Y, Ma N, Pinlaor S, Pairojkul C, Wongkham C, Sripa B, Khuntikeo N, Kawanishi S, Murata M
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Journal Title
Free Radic. Biol Med.
Volume: 52(8)
Related Report
Peer Reviewed
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[Journal Article] Proton pump inhibitors suppress iNOS-dependentDNA damage in Barrett's esophagus by increasing Mn-SOD expression2012
Author(s)
Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 421
Pages: 280-285
Related Report
Peer Reviewed
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[Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosomahaematobium infection2011
Author(s)
Ma N, Thanan R, Kobayashi H, Hammam O, Wishahi M, Leithy TE, Hiraku Y, Amro el K, Oikawa S, Ohnishi S,Murata M,Kawanishi S
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 414
Pages: 344-349
Related Report
Peer Reviewed
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[Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relati on to nitrative stress. The 7th International Conference on the Biology2012
Author(s)
Yingxi Mo, Ning Ma, Shumin Wang, Zhe Zhang, Ying Xie, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa Shosuke Kawanishi, Mariko Murata
Organizer
Chemistry and Therapeutic Applications of Nitric Oxide
Place of Presentation
Edinburgh, UK
Related Report
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[Presentation] Protein carbonylation in liver fluke-induced cholangiocarcinoma in relation to poor prognosis2012
Author(s)
Raynoo Thanan, Shinji Oikawa, Puangrat Yongvanit, Yusuke Hiraku, Ning Ma, Somchai Pinlaor, Chawalit Pairojkul, Chaisiri Wongkham, Banchob Sripa, Shosuke Kawanishi, Mariko Murata
Organizer
Mahidol International Conference on Infection and Cancer
Place of Presentation
Bangkok, Thailand
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[Presentation] Protein carbonylation in liver fluke-induced cholangiocarcinoma in relation to poor prognosis.2012
Author(s)
Raynoo Thanan, Shinji Oikawa, Puangrat Yongvanit , Yusuke Hiraku, Ning Ma, Somchai Pinlaor, Chawalit Pairojkul, Chaisiri Wongkham, Banchob Sripa, Shosuke Kawanishi and Mariko Murata
Organizer
Mahidol International Conference on Infection and Cancer.
Place of Presentation
The Landmark Hotel (Bangkok, Thailand)
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