| Project/Area Number |
23659327
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
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| Co-Investigator(Kenkyū-buntansha) |
MIDORIKAWA Kaoru 三重大学, 大学院・医学系研究科, リサーチアソシエイト (20393366)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / 上咽頭癌 / microRNA / ターゲット遺伝子 / バイオマーカー / Epstein-Barrウィルス / 発がん機構 / In silico 解析 / microRNA機能解析 / Epstein-Barr ウィルス / DNAメチル化 / マイクロアレイ解析 / 次世代シークエンサー |
|---|
| Research Abstract |
Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is one of the inflammation-associated cancers. To explore the mechanisms of NPC development and certain biomarkers for screening, a microarray profiling survey was performed to reveal the expression patterns of microRNAs across primary tumors (NPC) and normal nasopharyngeal epithelia (NNE). Quantitative real-time PCR confirmed that expression levels of the microRNAs were significantly different between NPC and NNE tissues. Several microRNAs also have significant differences in plasma samples. Up- and down-regulated microRNAs may play a role in NPC development and there is a possibility to use as biomarkers and novel targets for NPC treatment.
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