Risk assessment of fibrous and particulate matters on the basis of microRNomics
| Project/Area Number |
23659328
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 繊維・粒子状物質 / マイクロRNA / 石綿 / シリカ / 黄砂 / カーボンナノチューブ / マイクロアレイ / リスク評価 / 健康障害 / バイオマーカー |
|---|
| Research Abstract |
Fibrous and particulate matters cause inflammation in respiratory systems, leading to carcinogenesis and fibrosis. It is necessary to establish the system to evaluate the risk of these matters. microRNA (miRNA) is expected as a potential biomarker for various human diseases. In this study, we found that the expression of some miRNAs was significantly changed in the lung of mice exposed to asbestos, Asian dust and silica. These results suggest that miRNA can be used as a biomarker to evaluate the risk of these matters.
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Report
(3 results)
Research Products
(62 results)
