| Project/Area Number |
23659329
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Kyoto University |
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Principal Investigator |
KOIZUMI Akio 京都大学, 医学研究科, 教授 (50124574)
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| Co-Investigator(Renkei-kenkyūsha) |
HARADA Kouji 京都大学, 医学研究科, 准教授 (80452340)
HITOMI Toshiaki 京都大学, 医学研究科, 講師 (90405275)
IWASAWA Kokoro 東京大学, 生産技術研究所, 研究員 (30402796)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | もやもや病 / 動物モデル / mysterin / Akita mouse / 血管病変 |
|---|
| Research Abstract |
Mysterin, of which function remains explored little, is a susceptibility gene for moyamoya disease, of which R4810K variant is the founder variant among Asian moyamoya patients. We investigated phenotypes of KO mouse for angiogenesis, immune function, endoplasmic (ER) stress responses. We foundthat diabetic phenotype in the F1 offsprings between KO mouse and Akita mice was progressed significantly slowly when compared with the progression in Akita mise. We thus concluded that mysterin is involved in protein degradation by ER-stress associated protein degradation system.
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