A novel study elucidating risk of particulate matters using iPS

• Project/Area Number: 23659337
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene
• Research Institution: International University of Health and Welfare
• Principal Investigator: INOUE Ken-ichiro 国際医療福祉大学, 保健医療学部, 教授 (20373219)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 環境保健 / 衛生 / 再生医学

Research Abstract

At first, we examined in vitro assay conditions differentiating iPS toward cardiac cells such as myocytes and vascular endothelial cells , and developed condition differentiating iPS-derived myocytes. Next, we investigated the in vitro effects of diesel exhaust particle (DEP) -exposure on iPS-derived myocytes, and found that DEP tended to suppress pulsation of these cells as compared to vehicle-exposure.