Central arterial pressure, as a novel risk factor for cardiovascular diseases

• Project/Area Number: 23659352
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Public health/Health science
• Research Institution: Kyoto University (2012-2013); Ehime University (2011)
• Principal Investigator: TABARA yasuharu 京都大学, 医学(系)研究科(研究院), 准教授 (00268749)
• Co-Investigator(Kenkyū-buntansha): MIKI Tetsuro 愛媛大学, プロテオ医学研究センター, 教授 (00174003) ; KOHARA Katsuhiko 愛媛大学, 大学院医学系研究科, 准教授 (30260384)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 中心血圧 / 血圧動揺性 / 循環器疾患 / 動脈硬化 / リスクマーカー

Research Abstract

To clarify the clinical and epidemiological significance of central blood pressure measurements, we conducted cross-sectional studies in general population samples. Results showed that insulin resistance and smoking were independent determinant for central hemodynamics, suggesting an importance of central blood pressure measurements in clinical setting. We also clarified that increased blood pressure variability was significantly associated with asymptomatic lacunar infarction; however, central blood pressure variability was not superior to that of brachial blood pressure in association with lacunar infarction.

Research Products

• [Journal Article] Postprandial hypotension as a risk marker for asymptomatic lacunar infarction (2014)
  • Author(s): Tabara Y, Okada Y, Uetani E, Nagai T, Igase M, Kido T, Ochi N, Ohara M, Takita R, Kohara K, Miki T
  • Journal Title: J Hypertens Volume: 32 Pages: 1084-90
  • NAID: 120005651932
• [Journal Article] Postprandial hypotension as a risk marker for asymptomatic lacunar infarction. (2014)
  • Author(s): Tabara Y, Okada Y, Uetani E, Nagai T, Igase M, Kido T, Ochi N, Ohara M, Takita R, Kohara K, Miki T.
  • Journal Title: J Hypertens Volume: 32 Issue: 5 Pages: 1084-1090
  • DOI: 10.1097/hjh.0000000000000150
  • NAID: 120005651932
  • Peer Reviewed
• [Journal Article] Nagahama Study Group. Increased aortic wave reflection and smaller pulse pressure amplification in smokers and passive smokers confirmed by urinary cotinine levels : the Nagahama Study (2013)
  • Author(s): Tabara Y, Takahashi Y, Setoh K, Muro S, Kawaguchi T, Terao C, Kosugi S, Sekine A, Yamada R, Mishima M, Nakayama T, Matsuda F
  • Journal Title: Int J Cardiol Volume: 168 Pages: 2673-7
• [Journal Article] Association of longer QT interval with arterial waveform and lower pulse pressure amplification : the Nagahama Study (2013)
  • Author(s): Tabara Y, Takahashi Y, Kohara K, Setoh K, Kawaguchi T, Terao C, Igase M, Yamada R, Kosugi S, Sekine A, Miki T, Nakayama T, Matsuda F; Nagahama Study Group
  • Journal Title: Am J Hypertens Volume: 26 Pages: 973-80
  • NAID: 120005474538
• [Journal Article] Increased aortic wave reflection and smaller pulse pressure amplification in smokers and passive smokers confirmed by urinary cotinine levels: The Nagahama Study. (2013)
  • Author(s): Tabara Y, Takahashi Y, Setoh K, Muro S, Kawaguchi T, Terao C, Kosugi S, Sekine A, Yamada R, Mishima M, Nakayama T, Matsuda F; on behalf of the Nagahama Study Group.
  • Journal Title: Int J Cardiol. Volume: in press
  • NAID: 120005343927
  • Peer Reviewed
• [Journal Article] Association of longer QT interval with arterial waveform and lower pulse pressure amplification: the Nagahama Study (2013)
  • Author(s): Tabara Y, Takahashi Y, Kohara K, Setoh K, Kawaguchi T, Terao C, Igase M, Yamada R, Kosugi S, Sekine A, Miki T, Nakayama T, Matsuda F
  • Journal Title: Am J Hypertens Volume: in press
  • NAID: 120005474538
  • Peer Reviewed
• [Journal Article] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance : the Toon Health Study (2011)
  • Author(s): Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T
  • Journal Title: J Hypertens Volume: 29 Pages: 1948-54
• [Journal Article] Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance: the Toon Health Study. (2011)
  • Author(s): Tabara Y, Saito I, Nishida W, Kohara K, Sakurai S, Kawamura R, Onuma H, Takata Y, Osawa H, Miki T, Tanigawa T.
  • Journal Title: J Hypertens. Volume: 29 Pages: 1948-54
  • Peer Reviewed
• [Presentation] 一般地域住民における食事性低血圧と無症候性脳血管障害 (2013)
  • Author(s): 田原康玄,伊賀瀬道也,岡田陽子,永井勅久,上谷英里,多喜田理絵,城戸知子,越智南美子,小原克彦,三木哲郎
  • Organizer: 第55回日本老年医学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 中心血圧に対するインスリン抵抗性・感受性の影響 (2012)
  • Author(s): 田原康玄・斉藤功・西田亙・小原克彦・櫻井進・川村良一・大沼 裕・髙田康徳・大澤春彦・三木哲郎・谷川武
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-27
• [Presentation] 中心血圧測定の可能性と限界 (2011)
  • Author(s): 小原克彦・田原康玄・伊賀瀬道也・三木哲郎
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-21