| Project/Area Number |
23659353
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Public health/Health science
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| Research Institution | Kyushu University |
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Principal Investigator |
IWASE Masanori 九州大学, 医学研究院, 特別教員 (00203381)
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| Co-Investigator(Kenkyū-buntansha) |
KIYOHARA Yutaka 九州大学, 医学研究院, 教授 (80161602)
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| Co-Investigator(Renkei-kenkyūsha) |
KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187)
SASAKI Satoshi 東京大学, 医学(系)研究科, 教授 (70275121)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 糖尿病 / うつ / 生存率 / 疫学調査 / 疫学 / 糖尿病合併症 / 断面調査 / データベース / インスリン抵抗性 / 微小炎症 / 一般地域住民 / 糖尿病神経障害 / 低血糖 / 身体活動量 |
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| Research Abstract |
Depression has been reported to be frequently associated with diabetes mellitus. However, the large-scale epidemiological studies have not been performed in our country. Fukuoka Diabetes Registry, a prospective cohort study, composing of 5131 diabetic patients showed 8.9% of participants having depressive symptoms. As a nondiabetic controlgroup, the Hisayama study revealed 4.0% of residents with depressive symptoms. After controlling for confounding factors, odds ratio for the presence of depressive symptoms was 2.6 in diabetic patients. Furthermore, diabetic patients with depressive symptoms have unhealthy life style including diet and exercise as well as obesity, insulin resistance, poor glycemic control, hypoglycemia and diabetic complications as compared with those without depressive symptoms. Finally, the survival rate was significantlyworse in diabetic patients with depressive symptoms than those without. The present study emphasizes the importance of depression in treatment of diabetes mellitus.
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