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Clinico-epidemiological relevance of serum oxygenated B_2-microglobulin

Research Project

Project/Area Number 23659364
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Public health/Health science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

SHINKAI Shoji  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60171063)

Co-Investigator(Kenkyū-buntansha) TODA Toshifusa  横浜市立大学, 先端医科学研究センター, 教授 (80133635)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords血清β2 ミクログロブリン / 分子修飾 / 臨床疫学的意義 / 高齢者 / β2ミクログロブリン
Research Abstract

This study aimed to examine the clinico-epidemiologic relevance of serum oxygenated β2-microglobulin (β2-M) found in sera only from older adults. The method for detecting oxygenated β2-M with mass-spectrophotometry was not stable and we finally abandoned further to develop the method. Instead, we examined further the role of serum total β2-M for predicting cardiovascular mortality and found that serum β2-M is a novel risk marker for stroke mortality but not for heart disease mortality in a general population of older adults.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (45 results)

All 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 9 results) Presentation (23 results) (of which Invited: 4 results) Book (5 results) Remarks (2 results)

  • [Journal Article] 『介護予防チェックリスト』の虚弱指標としての妥当性の検証.2013

    • Author(s)
      新開省二, 渡辺直紀, 吉田裕人, 藤原佳典, 西真理子, 深谷太郎, 李相侖, 金美芝,小川貴志子, 村山洋史, 谷口優, 清水由美子
    • Journal Title

      日本公衆衛生雑誌

      Volume: 60 Pages: 262-274

    • NAID

      10031176568

    • Related Report
      2012 Final Research Report
  • [Journal Article] 『介護予防チェックリスト』の虚弱指標としての妥当性の検証2013

    • Author(s)
      新開省二
    • Journal Title

      日本公衆衛生雑誌

      Volume: 60

    • NAID

      10031176568

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunoprotective effects of oral intake of heat-killed Lactobacillus pentosus strain b240 in elderly adults : A randomized, double-blind, placebo-controlled trial2012

    • Author(s)
      Shinkai S, Toba M, Saito T, Sato I, Tsubouchi M, Taira K, Kakumoto K, Inamatsu T, Yoshida H, Fujiwara Y, Fukaya T, Matsumoto T, Tateda K, Yamaguchi K, Kohda N, Kohno S
    • Journal Title

      Br J Nutr

      Volume: 109 Issue: 10 Pages: 1-10

    • DOI

      10.1017/s0007114512003753

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A prospective study of gait performance and subsequent cognitive decline in a general population of older Japanese2012

    • Author(s)
      Taniguchi Y, Yoshida H, Fujiwara Y, Motohashi Y, Shinkai S
    • Journal Title

      J Gerontol A Biol Sci Med Sci 2012 Jun

      Volume: 67(7) Issue: 7 Pages: 796-803

    • DOI

      10.1093/gerona/glr243

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Hatoyama Cohort Study: Design and Profile of Participants at Baseline2012

    • Author(s)
      Murayama H, Nishi M, Shimizu Y, Kim M-J, Yoshida H, Amano H, Fujiwara Y, Shinkai S
    • Journal Title

      Journal of Epidemiology

      Volume: 22 Issue: 6 Pages: 551-558

    • DOI

      10.2188/jea.JE20120015

    • NAID

      10031126939

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2012 Final Research Report
  • [Journal Article] FI-J(Frailty Index for Japanese elderly)を用いた「虚弱」の予知因子に関する研究2012

    • Author(s)
      吉田裕人, 西真理子, 渡辺直紀, 藤原佳典, 深谷太郎, 小川貴志子, 金美芝, 李相侖,新開省二
    • Journal Title

      日本老年医学会雑誌

      Volume: 49 Pages: 442-448

    • NAID

      130004485829

    • Related Report
      2012 Final Research Report
  • [Journal Article] 地域在宅高齢者における「虚弱(Frailty)の疫学的特徴2012

    • Author(s)
      西真理子, 新開省二, 吉田裕人, 藤原佳典, 深谷太郎, 天野秀紀, 小川貴志子, 金美芝, 渡辺直紀
    • Journal Title

      日本老年医学雑誌

      Volume: 49 Pages: 344-354

    • NAID

      40019365647

    • Related Report
      2012 Final Research Report
  • [Journal Article] 地域在宅高齢者における「虚弱(Frailty)」の疫学的特徴2012

    • Author(s)
      西真理子
    • Journal Title

      日本老年医学雑誌

      Volume: 49 Pages: 344-354

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FI-J(Frailty Index for Japanese elderly)を用いた「虚弱」の予知因子に関する研究2012

    • Author(s)
      吉田裕人
    • Journal Title

      日本老年医学雑誌

      Volume: 49 Pages: 442-448

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A prospective study of gait performance and subsequent cognitive decline in a general population of older Japanese2012

    • Author(s)
      Taniguchi Y, Yoshida H, Fujiwara Y, Motohashi Y, Shinkai S
    • Journal Title

      J Gerontol: MEDICAL SCIENCES

      Volume: 67A

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 地域在宅高齢者における「虚弱(Frailty)」の疫学的特徴2012

    • Author(s)
      西真理子, 新開省二, 吉田裕人, 藤原佳典, 深谷太郎, 天野秀紀, 渡辺直紀, 小川貴志子, 金美芝
    • Journal Title

      日老医誌

      Volume: 49

    • NAID

      40019365647

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] FI-J(Frailty Index for Japanese elderly patient)を用いた「虚弱」の予知因子に関する研究2012

    • Author(s)
      吉田裕人, 西真理子, 渡辺直紀, 藤原佳典, 新開省二, 深谷太郎, 小川貴志子, 金美芝, 李相侖, 新開省二
    • Journal Title

      日老医誌

      Volume: 49

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals.2011

    • Author(s)
      Horibe H, Kato K, Oguri M, Yoshida T, Fujimaki T, Kawamiya T, Yokoi K, Watanabe S, Satoh K, Aoyagi Y, Tanaka M, Yoshida H, Shinkai S, Nozawa Y, Murohara T, Yamada Y
    • Journal Title

      Am J Hypertension

      Volume: 24 Pages: 924-929

    • Related Report
      2012 Final Research Report
  • [Journal Article] Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.2011

    • Author(s)
      Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, Aoyagi Y, Tanaka M, Fujiwara Y, Yoshida H, Shinkai S, Satoh K, Kato K, Fujimaki T, Yokoi K, Oguri M, Yoshida T, Watanabe S, Nozawa Y, Hasegawa A, Kojima T, Han B-G, Ahn Y, Lee M, Shin D-J, Lee JH, Jang Y
    • Journal Title

      Atherosclerosis

      Volume: 215 Pages: 145-152

    • Related Report
      2012 Final Research Report
  • [Journal Article] 「基本チェックリスト」を用いた虚弱判定と虚弱高齢者の血液生化学・炎症マーカーの特徴2011

    • Author(s)
      小川貴志子, 藤原佳典, 吉田裕人, 西真理子, 深谷太郎, 金美芝, 天野秀紀, 李相侖, 渡辺直紀, 新開省二
    • Journal Title

      日老医誌

      Volume: 48 Pages: 545-552

    • NAID

      10031130866

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Active aging and policy responses in Japan.2012

    • Author(s)
      Shinkai S
    • Organizer
      The key mote lecture at The Korean Gerontological Society Annual Scientific Meeting
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 介護予防の戦略2012

    • Author(s)
      新開省二
    • Organizer
      第61回日本農村医学会学術総会
    • Place of Presentation
      松江
    • Year and Date
      2012-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 高齢者の栄養状態と余命および死因別死亡2012

    • Author(s)
      新開省二
    • Organizer
      第3回食肉学術フォーラム委員会
    • Year and Date
      2012-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 50歳を過ぎたら粗食はやめなさい!2012

    • Author(s)
      新開省二
    • Organizer
      日本基礎廊下学会(JSBG)效果以降座「咀しゃく・栄養・病気=高齢者の食生活=」
    • Year and Date
      2012-07-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 健康余命を延伸する社会システムの開発=最新の老年学研究から=2012

    • Author(s)
      新開省二
    • Organizer
      第60回医療ビジネス研究会
    • Year and Date
      2012-04-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 疫学研究からみた日本人高齢者の栄養と余命および死因別死亡2012

    • Author(s)
      新開省二
    • Organizer
      日本栄養・食糧学会関東支部第14回脂質栄養シンポジウム
    • Year and Date
      2012-01-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of a brief questionnaire for screening frailty among Japanese older adults.2012

    • Author(s)
      Shinkai S, Yoshida H, Nishi M, Murayama H, Fujiwara Y, Kim M-J
    • Organizer
      The Gerontological Society of America's 65th Annual Scientific Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 草津町における介護予防10年間の歩みと成果(1)ねらいとプロセス評価2012

    • Author(s)
      新開省二, 吉田裕人, 深谷太郎, 藤原佳典, 天野秀紀, 西真理子, 村山洋史, 谷口優,野藤悠, 干川なつみ, 土屋由美子
    • Organizer
      第71回日本公衆衛生学会総会
    • Place of Presentation
      山口
    • Related Report
      2012 Final Research Report
  • [Presentation] Prevention of frailty and healthy ageing : a 10-year community intervention and outcome.2012

    • Author(s)
      Shinkai S
    • Organizer
      A symposium at Ageing Societies in Europe and Japan : Policy Responses and Research & Innovation Solutions for Active and Healthy Ageing
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 高齢者低栄養の疫学-低栄養はなにをもたらすか2012

    • Author(s)
      新開省二
    • Organizer
      シンポジウム2「高齢者の栄養学-低栄養を中心に」第34回日本臨床栄養学会総会/第33回日本臨床栄養協会総会第10回大連合大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 地域在住高齢者における多周波部位別生体電気インピーダンス法による身体組成評価の妥当性の検討2012

    • Author(s)
      金 美芝, 村山洋史, 吉田裕人, 西真理子, 藤原佳典, 新開省二, 森聖二郎
    • Organizer
      第54回日本老年医学会学術集会
    • Related Report
      2012 Final Research Report
  • [Presentation] 高齢者の低栄養の疫学-低栄養はなにをもたらすか2012

    • Author(s)
      新開省二
    • Organizer
      第34回日本臨床栄養学会総会/第33回日本臨床栄養協会(シンポジウム)
    • Place of Presentation
      市川市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Prevention of frailty and healthy ageing: A 10-year community intervention and outcome2012

    • Author(s)
      Shinkai S
    • Organizer
      Ageing Societies in Europe and Japan: Policy Responses and Research & Innovation Solutions for Active and Healthy Ageing (Symposium)
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Epidemiologic study on frailty using the Japanese-version of Frailty Index. Prevalence, outcomes, and predictors.2011

    • Author(s)
      Shinkai S
    • Organizer
      The 11th Korea-Japan Joint Symposium. The 48th Annual Congress of the Korean Geriatrics Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 健康長寿に関する運動疫学研究の成果と課題.2011

    • Author(s)
      新開省二
    • Organizer
      健康長寿医療センター追跡研究(TMIG-LISA), 第66回日本体力医学会大会 ワークショップ6
    • Place of Presentation
      下関
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Physical performance and cardiovascular death in a general population of older Japanese.2011

    • Author(s)
      Shinkai S, Fujiwara Y, Yoshida H, Nishi M, Murayama H, Yoshida H, Suzuki T
    • Organizer
      The Gerontological Society of America 64th Annual Scientific Meeting
    • Place of Presentation
      Boston, MA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Frailty Index for Japanese Older Adults : A Validation Study of the 15-items Questionnaire 'Kaigo-Yobo Check-List' as a Frailty Index.2011

    • Author(s)
      Shinkai S, Yoshida H, Nishi M. Fujiwara Y, Fukaya T, Ogawa K, Kim MJ
    • Organizer
      9th Asia / Oceania Regional Congress of Geriatrics and Gerontology
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Final Research Report
  • [Presentation] Frailty Index(虚弱指標)の開発~『介護予防チェックリスト』のFrailty Index(虚弱指標)としての妥当性の検証~2011

    • Author(s)
      新開省二, 渡辺直紀, 吉田裕人, 西真理子, 村山洋史, 天野秀紀, 藤原佳典, 深谷太郎, 小川貴志子, 金美芝, 李相侖
    • Organizer
      第70回日本公衆衛生学会総会
    • Place of Presentation
      秋田
    • Related Report
      2012 Final Research Report
  • [Presentation] 血清β2-microglobulin と主要死因別死亡に関する10年間の前向き研究2011

    • Author(s)
      新開省二, 藤原佳典, 天野秀紀, 吉田裕人, 西真理子, 吉田英世, 鈴木隆雄
    • Organizer
      第53回日本老年医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Physical performance and cardiovascular death in a general population of older Japanese2011

    • Author(s)
      Shinkai S
    • Organizer
      The Gerontological Society of America 64th Annual Scientific Meeting
    • Place of Presentation
      Boston, MA, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Epidemiologic study on frailty using the Japanese-version of Frailty Index. Prevalence, outcomes, and predictors2011

    • Author(s)
      Shinkai S
    • Organizer
      The 11th Korea-Japan Joint Symposium. The 48th Annual Congress of the Korean Geriatrics Society.(招待講演)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] 介護予防の戦略

    • Author(s)
      新開省二
    • Organizer
      第61回日本農村医学会学術総会(教育講演)
    • Place of Presentation
      松江市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Active aging and policy responses in Japan

    • Author(s)
      Shinkai S
    • Organizer
      The Korean Gerontological Society Annual Scientific Meeting (Key note lecture)
    • Place of Presentation
      Daegu
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 心身の老化・健康・長寿. 発達科学入門[3]青年期~後期高齢期(高橋惠子・湯川良三・安藤寿康・秋山弘子, 編)2012

    • Author(s)
      新開省二
    • Publisher
      東京大学出版会
    • Related Report
      2012 Final Research Report
  • [Book] III. 介護予防編4. 低栄養予防と改善に向けたエクササイズ.健康・エクササイズ科学(田中喜代次, 田畑泉, 編)2012

    • Author(s)
      新開省二, 成田美紀
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] 第5章 老化と免疫. 管理栄養士講座 感染と生体防御 第二版(酒井徹,森口覚, 山本茂 編)2012

    • Author(s)
      新開省二
    • Publisher
      建帛社
    • Related Report
      2012 Final Research Report
  • [Book] 発達科学入門[3]青年期~後期高齢期(高橋惠子・湯川良三・安藤寿康・秋山弘子、編)2012

    • Author(s)
      新開省二
    • Publisher
      東京大学出版会
    • Related Report
      2012 Annual Research Report
  • [Book] 発達科学入門3巻(高橋惠子・湯川良三・安藤寿康・秋山弘子, 編)2012

    • Author(s)
      新開省二
    • Total Pages
      291
    • Publisher
      東京大学出版会
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www2.tmig.or.jp/spch/

    • Related Report
      2012 Final Research Report
  • [Remarks] http://www2.tmig.or.jp/spch/index.html

    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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