| Project/Area Number |
23659371
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 骨髄前駆細胞 / EPC / ケモカイン / 皮膚損傷 / 受傷後経過時間 / ＥＰＣ |
|---|
| Research Abstract |
BM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in wound repair. Ccr5-/- mice showed delayed sin wound healing with the reduction of EPC accumulation at the wound sites. These observations implied that CCR5-mediated signal can regulate EPC recruitment from the bone marrow. Moreover, the detection of EPCs in human skin wounds could be a useful marker for wound age determination in forensic practices.
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