Are bone marrow-derived endothelial progenitor cells a potential marker for wound age determination?
| Project/Area Number |
23659371
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 骨髄前駆細胞 / EPC / ケモカイン / 皮膚損傷 / 受傷後経過時間 / ＥＰＣ |
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| Research Abstract |
BM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in wound repair. Ccr5-/- mice showed delayed sin wound healing with the reduction of EPC accumulation at the wound sites. These observations implied that CCR5-mediated signal can regulate EPC recruitment from the bone marrow. Moreover, the detection of EPCs in human skin wounds could be a useful marker for wound age determination in forensic practices.
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Report
(3 results)
Research Products
(27 results)
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[Presentation] Detection of endothelial progenitor cells in human skin wounds and its application for wound age determination.2012
Author(s)
Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Kawaguchi M, Kawaguchi T, Hama M, Abe M, Eisenmenger W, Kondo T
Organizer
91. Jahrestagung der Deutschen Gesellschaft for Rechtsmedizin in Verbingdung mit 1st Symposium on Interpersonal Violence in Social Proximity
Place of Presentation
Freiburg, Germany
Related Report
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