| Project/Area Number |
23659375
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
EBIHARA TAKAE 東北大学, 加齢医学研究所, 助教 (30396478)
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| Co-Investigator(Kenkyū-buntansha) |
EBIHARA Satoru 東北大学病院, 講師 (90323013)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | capsite(CH-19) / TRPアゴニスト / 誤嚥 / 嚥下造影 / 低栄養 / 高齢者 / TRPV1アゴニスト / カプサイシン類縁体 / 摂食嚥下障害 / 栄養不良 / 嚥下障害 / ＴＲＰＶ１ / カプサイシン / カプシエイト / ふりかけ / カプシエート / TRPV1 |
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| Research Abstract |
Capsiate is produced by'CH-19 Sweet',a non-pungent cultivar of red pepper. Like capsaicin, capsiate is thought to enhance energy metabolism by activating the sympathetic nervous system and suppressing inflammation. In addition, we previously reported that transient receptor potential vanilloid 1(TRPV1) agonist can improve the swallowing reflex, which is one of risk factor of microaspiration for penumonia in the elderly. However, it is unknown whether TRP agonist including capsaicin and capsiate exert on the bolus swallows.
Participants at the level of malnutrition by dysphagia were examined their function of swallowing by videofluorography.
They were given capsaite-topped jelly or capsiate-untopped jelly. This result have shown that the opening or closure time, the degree of expansion of various parts oropharungeal stage people given capsiate-topped jerry was significantly improved(P<0.01). Capsiate(CH-19 sweet)can improve the sensory and motor reflex of swallowing.
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