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capsaiate CH-19 sweet is possible to prevent aspiration pneumonia in the elderly

Research Project

Project/Area Number 23659375
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTohoku University

Principal Investigator

EBIHARA TAKAE  東北大学, 加齢医学研究所, 助教 (30396478)

Co-Investigator(Kenkyū-buntansha) EBIHARA Satoru  東北大学病院, 講師 (90323013)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordscapsite(CH-19) / TRPアゴニスト / 誤嚥 / 嚥下造影 / 低栄養 / 高齢者 / TRPV1アゴニスト / カプサイシン類縁体 / 摂食嚥下障害 / 栄養不良 / 嚥下障害 / TRPV1 / カプサイシン / カプシエイト / ふりかけ / カプシエート / TRPV1
Research Abstract

Capsiate is produced by'CH-19 Sweet',a non-pungent cultivar of red pepper. Like capsaicin, capsiate is thought to enhance energy metabolism by activating the sympathetic nervous system and suppressing inflammation. In addition, we previously reported that transient receptor potential vanilloid 1(TRPV1) agonist can improve the swallowing reflex, which is one of risk factor of microaspiration for penumonia in the elderly. However, it is unknown whether TRP agonist including capsaicin and capsiate exert on the bolus swallows.
Participants at the level of malnutrition by dysphagia were examined their function of swallowing by videofluorography.
They were given capsaite-topped jelly or capsiate-untopped jelly. This result have shown that the opening or closure time, the degree of expansion of various parts oropharungeal stage people given capsiate-topped jerry was significantly improved(P<0.01). Capsiate(CH-19 sweet)can improve the sensory and motor reflex of swallowing.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (35 results)

All 2014 2013 2012 2011

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (9 results) (of which Invited: 3 results) Book (2 results)

  • [Journal Article] Thermal taste and aspiration drugs : a novel drug discovery against pneumonia2014

    • Author(s)
      Ebihara S, Ebihara T, Gui P, Osaka K, Sumi Y, Kohzuki M
    • Journal Title

      Curr Pharm Des

      Volume: 20 Pages: 2755-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of cervical trachea and chest wall vibrations on cough reflex sensitivity and perception of urge-to-cough in healthy male never-smokers2013

    • Author(s)
      Kashiwazaki N, Ebihara S, Gui P, Katayama N, Ito K, Sato R, Oyama C, Ebihara T, Kohzuki M.
    • Journal Title

      Cough

      Volume: 9 Issue: 1 Pages: 22-22

    • DOI

      10.1186/1745-9974-9-22

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Response letter to Lakin and Doe.2013

    • Author(s)
      Ebihara S, Shannon F, Sakamoto Y et al.
    • Journal Title

      J Am Geriatr Soc

      Volume: 61 Issue: 2 Pages: 313-314

    • DOI

      10.1111/jgs.12108

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermal Taste and Anti-Aspiration Drugs: a Novel Drug Discovery against Pneumonia2013

    • Author(s)
      Ebihara S1, Ebihara T, Gui P et al.
    • Journal Title

      Curr Pharm Des.

      Volume: 1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of blunted perception of dyspnea on medical care use and expenditure, and mortality in elderly people.2012

    • Author(s)
      Ebihara S, Niu K, Ebihara T, Kuriyama S, Hozawa A, Ohmori-Matsuda K, Nakaya N, Nagatomi R, Arai H, Kohzuki M, Tsuji I.
    • Journal Title

      Front Physiol.

      Volume: 3 Pages: 238-238

    • DOI

      10.3389/fphys.2012.00238

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of olfactory stimulation on gait performance in frail older adults.2012

    • Author(s)
      Ebihara S, Nikkuni E, Ebihara T, Sakamoto Y, Freeman S, Kohzuki M.
    • Journal Title

      Geriatr. Geront. Int

      Volume: 12 Issue: 3 Pages: 567-8

    • DOI

      10.1111/j.1447-0594.2011.00801.x

    • NAID

      10030992070

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fall prevention using olfactory stimulation with lavender odor in elderly nursing home residents: a randomized controlled trial.2012

    • Author(s)
      Sakamoto Y,Ebihara S, Ebihara T, Tomita N, Toba K, Freeman S, Arai H, Kohzuki M.
    • Journal Title

      J Am Geraitr Soc

      Volume: 60 Issue: 6 Pages: 1005-1011

    • DOI

      10.1111/j.1532-5415.2012.03977.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urge to cough and dyspnea conceal perception of pain in healthy adults2012

    • Author(s)
      Gui P, Ebihara S, Ebihara T, Kanezaki M, Kashiwazaki N, Ito K, Kohzuki M
    • Journal Title

      Respir Physiol Neurobiol

      Volume: 181 Issue: 2 Pages: 214-9

    • DOI

      10.1016/j.resp.2012.03.010

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations2012

    • Author(s)
      Kanezaki M, Ebihara S, Gui P, Ebihara T, Kohzuki M
    • Journal Title

      Respir Med

      Volume: 106 Pages: 406-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] diponectin pathway attenuates malignant mesothelioma cell growth2012

    • Author(s)
      A. Niu K, Asada M, Okazaki T, Yamanda S, Ebihara T, Guo H, Zhang D, Nagatomi R, Arai H, Kohzuki M, Ebihara S
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 46 Pages: 515-23

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Aging on Cough and Swallowing Reflexes: Implications for Preventing Aspiration Pneumonia.2012

    • Author(s)
      Ebihara S, Ebihara T, Kohzuki M.
    • Journal Title

      Lung

      Volume: 190 Issue: 1 Pages: 29-33

    • DOI

      10.1007/s00408-011-9334-z

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional Decline after an emergency shelter stay : misleading evidence2012

    • Author(s)
      Tomita N. Une K, Ohrui T, Ebihara T, Kosaka Y, Okinaga S, Furukawa K, Arai H
    • Journal Title

      J Am Geriatr Soc

      Volume: 60 Issue: 12 Pages: 2380-2

    • DOI

      10.1111/jgs.12021

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cigarette smoking on cough reflex induced by TRPV1 and TRPA1 stimulations.2012

    • Author(s)
      Kanezaki M, Ebihara S, Gui P, Ebihara T, Kohzuki M.
    • Journal Title

      Respir Med

      Volume: 106 Pages: 406-12

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth2012

    • Author(s)
      Niu K, Asada M, et al
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 46 Issue: 4 Pages: 515-523

    • DOI

      10.1165/rcmb.2011-0068oc

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dysphagia in dementia2011

    • Author(s)
      Ebihara S and Ebihara T
    • Journal Title

      Nihon Rinsho

      Volume: 69 Pages: 517-21

    • NAID

      40019129037

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimulating oral and nasal chemoreceptors for preventing aspiration pneumonia in the elderly2011

    • Author(s)
      Ebihara S, Ebihara T, Yamasaki M, Kohzuki M
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 (PMID:22129 860) Pages: 1677-81

    • NAID

      130001871763

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers2011

    • Author(s)
      Ebihara S, Ebihara T, Kanezaki M, et al.
    • Journal Title

      Cough

      Volume: 7 Pages: 3-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensory stimulation to improve swallowing reflex and prevent aspiration pneumonia in elderly dysphagic people2011

    • Author(s)
      Ebihara S, Kohzuki M, Sumi Y, Ebihara T
    • Journal Title

      J Pharmacol Sci

      Volume: 115 Pages: 99-104

    • NAID

      10029891712

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cough in the elderly : a novel strategy for preventing aspiration pneumonia2011

    • Author(s)
      Ebihara S and Ebihara T
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 24 Pages: 318-23

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shelter-acquired pneumonia after a catastrophic earthquake in Japan2011

    • Author(s)
      Suzuki M, Uwano-Ooyama C, Ohrui T, Ebihara T, Yamasaki M, Asamura T, Tomita N, Kosaka Y, Furukawa K, Arai H
    • Journal Title

      J Am Geriatr Soc

      Volume: 59 (PMID:22091514) Issue: 10 Pages: 1968-70

    • DOI

      10.1111/j.1532-5415.2011.03610_6.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 17.Sensory stimulation to improve swallowing reflex and prevent aspiration pneumonia in elderly dysphagic people2011

    • Author(s)
      Ebihara S, Kohzuki M, Sumi Y, Ebihara T.
    • Journal Title

      J Pharmacol Sci.

      Volume: 115 Pages: 99-104

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers.2011

    • Author(s)
      Ebihara S, Ebihara T, Kanezaki M, Gui P, Yamasaki M, Arai H, Kohzuki M.
    • Journal Title

      Cough

      Volume: 7 Pages: 3-3

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stimulating oral and nasal chemoreceptors for preventing aspiration pneumonia in the elderly.2011

    • Author(s)
      Ebihara S, Ebihara T, Yamasaki M, Kohzuki M.
    • Journal Title

      Yakugaku Zasshi.

      Volume: 131 Pages: 1677-81

    • NAID

      130001871763

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 21.Cough in the elderly: a novel strategy for preventing aspiration pneumonia.2011

    • Author(s)
      Ebihara S, Ebihara T.
    • Journal Title

      Pulm Pharmacol Ther.

      Volume: 24 Pages: 318-24

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] シンポジウム「包括的女性医師支援戦略―東北大学―」2013

    • Author(s)
      全国大学医学部女性医師支援会議
    • Organizer
      海老原 孝枝
    • Place of Presentation
      東京
    • Year and Date
      2013-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] パネルディスカッション「嚥下障害と嚥下性肺炎を考える」-「内科的包括的誤嚥性肺炎予防戦略」2013

    • Author(s)
      海老原孝枝
    • Organizer
      第65回日本気管食道科学会総会ならびに学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム「包括的誤嚥性肺炎予防戦略」2013

    • Author(s)
      海老原 孝枝
    • Organizer
      エビデンスに基づく統合医療研究会
    • Place of Presentation
      日大阪・大阪大学
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム 包括的高齢者誤嚥性肺炎予防および内科的治療戦略2013

    • Author(s)
      海老原 孝枝
    • Organizer
      第65回日本気管食道学会
    • Place of Presentation
      東京品川プリンスホテル
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] シンポジウム 包括的誤嚥性肺炎予防戦略2013

    • Author(s)
      海老原 孝枝
    • Organizer
      第2回エビデンスに基づく統合医療研究会
    • Place of Presentation
      大阪大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] シンポジウム 包括的女性医師支援戦略ー東北大学2013

    • Author(s)
      海老原 孝枝
    • Organizer
      全国大学女性医師支援会議
    • Place of Presentation
      東京文京区 日本医師会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 要介護高齢者呼吸器感染の発症に対するビタミンD補充療法の効果2011

    • Author(s)
      浅村孝昭、海老原 孝枝
    • Organizer
      日本老年医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 赤ワインポリフェノールの高齢者嚥下反射の改善効果2011

    • Author(s)
      海老原覚,上月正博,海老原孝枝
    • Organizer
      日本老年医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 入院を契機に服薬管理能力が不十分だと判明したケースについての検討2011

    • Author(s)
      冨田尚希,宇根かおり,海老原孝枝
    • Organizer
      日本老年医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] 嚥下障害の臨床2012

    • Author(s)
      海老原孝枝、海老原覚
    • Publisher
      医歯薬出版
    • Related Report
      2012 Research-status Report
  • [Book] 認知症診療Q&A2012

    • Author(s)
      海老原孝枝、古川勝敏
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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