A correlative biomarker analysis of demented Patient's QOL.

• Project/Area Number: 23659376
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: AKISHITA Masahiro 東京大学, 医学部附属病院, 教授 (00261975)
• Co-Investigator(Kenkyū-buntansha): KOJIMA Taro 東京大学, 大学院医学系研究科加齢医学, 助教 (40401111) ; YAMAGUCHI Kiyoshi 東京大学, 大学院医学系研究科加齢医学, 助教 (20451817) ; KAMEYAMA Yumi 東京大学, 大学院医学系研究科加齢医学, 助教 (60505882)
• Co-Investigator(Renkei-kenkyūsha): IIJIMA Katsuya 東京大学, 高齢社会総合研究機構, 准教授 (00334384)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 認知症 / QOL / 表情解析 / SF-8 / 唾液アミラーゼ / バイオマーカー / コミュニケーション / 医療提供 / ＱＯＬ

Research Abstract

If QOL(Quality of life) in demented patients, who are unable to communicate can be evaluated, it is useful for judgment of medical adaptation, or the judgment of a curative effect. The conventional QOL evaluations are questionnaire type and it can't be used for the patient who can't communicate. QOL evaluation (SF-8) and a face photograph were taken of the patients who can communicate, and facial expression analysis was performed by medical workers and OKAO Vision(R).
The relationship between "sadness" of OKAO Vision(R) and mental health QOL is significant. It is expected that facial expression analysis is useful in QOL evaluation.

Research Products

• [Journal Article] Sarcopenia in Asia: consensus report of the asian working group for sarcopenia. (2014)
  • Author(s): Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, Chou MY, Chen LY, Hsu PS, Krairit O, Lee JS, Lee WJ, Lee Y, Liang CK, Limpawattana P, Lin CS, Peng LN, Satake S, Suzuki T, Won CW, Wu CH, Wu SN, Zhang T, Zeng P, Akishita M, Arai H
  • Journal Title: J Am Med Dir Assoc. Volume: 15 Issue: 2 Pages: 95-101
  • DOI: 10.1016/j.jamda.2013.11.025
  • Peer Reviewed
• [Journal Article] Association of decreased sympathetic nervous activity with mortality of older adults in long-term care (2014)
  • Author(s): Shibasaki K, Ogawa S, Yamada S, lijima K, Eto M, Kozaki K, Toba K, Akishita M, Ouchi Y
  • Journal Title: Geriatr Gerontol Int Volume: 14 Pages: 159-66
  • Peer Reviewed
• [Journal Article] Growing research on sarcopenia in Asia. (2014)
  • Author(s): Arai H, Akishita M, Chen LK
  • Journal Title: Geriatr Gerontol Int Volume: 14 Suppl 1 Issue: S1 Pages: 1-7
  • DOI: 10.1111/ggi.12236
  • Peer Reviewed
• [Journal Article] Association of decreased sympathetic nervous activity with mortality of older adults in long-term care. (2014)
  • Author(s): Shibasaki K, Ogawa S, Yamada S, Iijima K, Eto M, Kozaki K, Toba K, Akishita M, Ouchi Y.
  • Journal Title: Geriatr Gerontol Int Volume: 14 Issue: 1 Pages: 159-166
  • DOI: 10.1111/ggi.12074
  • Peer Reviewed
• [Journal Article] Respiratory dysrhythmia in dementia with Lewy bodies: a cross-sectional study (2013)
  • Author(s): Hibi S, Yamaguchi Y, Umeda-Kameyama Y, Takahashi M, Momose T, Akishita M, Ouchi Y.
  • Journal Title: BMJ Open Volume: 3(9): e002870 Issue: 9 Pages: e002870-e002870
  • DOI: 10.1136/bmjopen-2013-002870
  • Peer Reviewed
• [Journal Article] Priorities of Health Care Outcomes for the Elderly (2013)
  • Author(s): Akishita M, Ishii S, Kojima T, Kozaki K, Kuzuya M, Arai H, Arai H, Eto M, Takahashi R, Endo H, Horie S, Ezawa K, Kawai S, Takehisa Y, Mikami H, Takegawa S, Morita A, Kamata M, Ouchi Y, Toba K
  • Journal Title: J Am Med Dir Assoc Volume: 14 Pages: 479-484
  • Peer Reviewed
• [Journal Article] Priorities of healthcare outcomes for the elderly. (2013)
  • Author(s): Akishita M, Ishii S, Kojima T, Kozaki K, Kuzuya M, Arai H, Arai H, Eto M, Takahashi R, Endo H, Horie S, Ezawa K, Kawai S, Takehisa Y, Mikami H, Takegawa S, Morita A, Kamata M, Ouchi Y, Toba K
  • Journal Title: J Am Med Dir Assoc Volume: 479-848 Issue: 7 Pages: 479-484
  • DOI: 10.1016/j.jamda.2013.01.009
  • Peer Reviewed
• [Journal Article] The high frequency of periodic limb movements in patients with Lewy body dementia (2012)
  • Author(s): Hibi S, Yamaguchi Y, Umeda-Kameyama Y, Yamamoto H, IijimaK, Momose T, Akishita M, Ouchi Y
  • Journal Title: JPsychiatr Res Volume: 46 Issue: 12 Pages: 1590-4
  • DOI: 10.1016/j.jpsychires.2012.07.007
  • Peer Reviewed
• [Journal Article] Indications and practice for tube feeding in Japanese geriatricians : Implications of multidisciplinary team approach (2012)
  • Author(s): Ogita M, Utsunomiya H, Akishita M, Arai H
  • Journal Title: J Clin Gerontol Geriatr Volume: (印刷中) Issue: 4 Pages: 643-51
  • DOI: 10.1111/j.1447-0594.2011.00831.x
  • Peer Reviewed
• [Journal Article] Polypharmacy as a risk for fall occurrence in geriatric outpatients (2012)
  • Author(s): Kojima T, Akishita M, Nakamura T, Nomura K, Ogawa S, Iijima K, Eto M, Ouchi Y
  • Journal Title: Geriatr Gerontol Int Volume: 12 Pages: 425-30
  • NAID: 10030991471
  • Peer Reviewed
• [Journal Article] Factors associated with prolonged hospital stay in a geriatric ward of a university hospital in Japan (2012)
  • Author(s): Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M, Ouchi Y
  • Journal Title: J Am Geriatr Soc Volume: 60 Pages: 1190-1
  • Peer Reviewed
• [Journal Article] Obstructive sleep apnea exacerbates endothelial dysfunction in patients with metabolic syndrome (2011)
  • Author(s): Akishita M, Ohike Y, Yamaguchi Y, Iijima K, Eto M, Ouchi Y
  • Journal Title: J Am Geriatr Soc Volume: 59 Issue: 7 Pages: 1565-6
  • DOI: 10.1016/j.jacc.2013.05.045
  • Peer Reviewed
• [Journal Article] Plasma sex hormone levels and mortality in disabled older men and women (2011)
  • Author(s): Fukai S, Akishita M, Yamada S, Ogawa S,Yamaguchi K, Kozaki K, Toba K, Ouchi Y
  • Journal Title: Geriatr Gerontol Int Volume: 11 Pages: 196-203
  • NAID: 10029333495
  • Peer Reviewed
• [Journal Article] Association of hearing loss with behavioral and psychological symptoms in patients with dementia
  • Author(s): Umeda-Kameyama Y, lijima K, Yamaguchi K, Kidana K, Ouchi Y, Akishita M
  • Journal Title: Geriatr Gerontol Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] High risk of adverse drug reactions in elderly patients taking six or more drugs : analysis of inpatient database
  • Author(s): Kojima T, Akishita M, Kameyama Y, Yamaguchi K, Yamamoto H, Eto M, Ouchi Y
  • Journal Title: Geriatr Gerontol Int Volume: (in press)
  • Peer Reviewed
• [Presentation] Definition of polypharmacy to prevent drug-related geriatric syndrome (2013)
  • Author(s): Akishita M
  • Organizer: 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Seoul, Korea
• [Presentation] 認知症予防と進展予防の最前線.4.食習慣を変える、認知症を予防する (2013)
  • Author(s): 秋下雅弘
  • Organizer: Asian Aging Summit2013
  • Place of Presentation: 東京
• [Presentation] 認知症予防と進展予防の最前線．４．食習慣を買える、認知症を予防する (2013)
  • Author(s): 秋下雅弘
  • Organizer: Asian Aging Summit 2013
  • Place of Presentation: 東京
  • Invited
• [Presentation] Androgen is the key to ameliorate frailty (2013)
  • Author(s): Akishita M
  • Organizer: 9th Congress of the European Union Geriatric Medicine Society
  • Place of Presentation: Venice, Italy
  • Invited
• [Presentation] 高齢者フレイルティに迫る．５．危険因子 (2013)
  • Author(s): 秋下雅弘
  • Organizer: 日本老年医学会学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Future perspective on active ageing from rapidly ageing Asian countries : Polypharmacy and fall risk in geriatric patients (2012)
  • Author(s): Akishita M, Kojima T, Toba K, Ouchi Y
  • Organizer: 8th Congress of the European Union Geriatric Medicine Society
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2012-10-27
• [Presentation] Aging male and female : 将来を見据えて.医学は男性のQOLを救えるか (2012)
  • Author(s): 秋下雅弘
  • Organizer: 日本性機能学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-21
• [Presentation] [一次予防]認知症発症予防における高血圧症管理の意義 (2012)
  • Author(s): 秋下雅弘
  • Organizer: 日本認知症予防学会学術集会
  • Place of Presentation: 北九州
• [Presentation] ホルモンと認知症.アンドロゲンの認知機能改善作用 (2011)
  • Author(s): 秋下雅弘
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] 女性高齢者における遅延再生と嗅覚障害の関連 (2011)
  • Author(s): 亀山祐美、飯島勝矢、山口潔、本多正幸、小川純人、江頭正人、秋下雅弘、大内尉義
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-12
• [Presentation] 高齢者医療の優先順位に関する意識調査 (2011)
  • Author(s): 秋下雅弘、江頭正人、荒井秀典、神崎恒一、葛谷雅文、荒井啓行、高橋龍太郎、江澤和彦、川合秀治、鳥羽研二
  • Organizer: 日本老年医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-17
• [Presentation] 高齢者の経管栄養療法の実態 第二報 : 老年病専門医師が考える高齢者の経管栄養療法導入を決定する理由 (2011)
  • Author(s): 荻田美穂子、荒井秀典、秋下雅弘
  • Organizer: 日本老年医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-17
• [Presentation] 認知症患者の老々介護ストレスとその性差 (2011)
  • Author(s): 亀山祐美、秋下雅弘、山口潔、小川純人、飯島勝矢、江頭正人、大内尉義
  • Organizer: 日本老年医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-17
• [Presentation] ホルモンと認知症．アンドロゲンの認知機能改善作用 (2011)
  • Author(s): 秋下雅弘
  • Organizer: 日本認知症学会学術集会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 認知症の老年医学的管理
  • Author(s): 秋下 雅弘
  • Organizer: 日本早期認知症学会
  • Place of Presentation: 甲府市総合市民会館（甲府市）
  • Invited
• [Presentation] 認知症発症予防における高血圧症管理の意義
  • Author(s): 秋下 雅弘
  • Organizer: 日本認知症予防学会学術集会
  • Place of Presentation: 北九州国際会議場（北九州市）
  • Invited
• [Book] 高齢者のための薬の使い方 ストップとスタート (2013)
  • Author(s): 秋下雅弘, 他.秋下雅弘 編集
  • Total Pages: 182
  • Publisher: (株)ぱーそん書房・東京
• [Book] 健康長寿診療ハンドブック―実地医家のための老年医学のエッセンス (2011)
  • Author(s): 作成委員会コアメンバー(秋下雅弘).編集/発行 日本老年医学会
  • Total Pages: 160
  • Publisher: メジカルビュー社・東京