| Project/Area Number |
23659381
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
MITSUDA Noriaki 愛媛大学, 大学院・医学系研究科, 教授 (10314329)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 赤血球 / 酸化ストレス / 貧血 / 高齢者 / 慢性炎症 / 動脈硬化 / 鉄代謝 |
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| Research Abstract |
I analyzed the association of the anemia of the elderly people with oxidation stress history saved on the red blood cell membrane of the testees of the anti-aging dock which is carried out in the Center for Anti-aging and Preventive Medicine attached to the Ehime University hospital. As a result, there was a negative correlation between the oxidated fat content in erythrocyte membrane and the red blood cell count, suggesting that the oxidated fat content in erythrocyte membrane could become the index of anemia. On the other hand, there was significant correlation between the SH-group content in erythrocyte membrane and the degree of arteriosclerosis, in the male. The participation of a factor (e.g., female sex hormone) peculiar to a woman was suggested, because no significance was detected, in women.
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