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A prospective study of cognitive function, activities of daily living and cerebral white matter lesion in the elderly in group home.

Research Project

Project/Area Number 23659388
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionTokai University

Principal Investigator

MORI Hidezo  東海大学, 医学部, 教授 (90146598)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糖尿病 / 医療・福祉 / 循環器・高血圧 / グループホーム / 加齢医学 / 放射線・X線・粒子線 / 放射線・X線・粒子線
Research Abstract

LAIDS study(BMJ2009)demonstrated that cerebral white matter disease in subcorticl lesion relates cognitive function, depression, falling down, and/or swallowing disorder. However, such prospectibve studies are rare in Japan. In the present study, we performed a prospective observational study for three years concnerning clinical symptoms, MRI and cardiac function of the elderly in group home and compared these observations to those of age-matched control patients who visit out-patient clinic of cardiology or neurosurgery in a city hospital.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (42 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (31 results) Book (3 results)

  • [Journal Article] Protective effect of tryptophan against dextran sulfate sodium-induced experimental colitis2013

    • Author(s)
      T.Shizuma, H.Mori, N.Fukuyama
    • Journal Title

      The Turkish Journal of Gastroenterology

      Volume: Vol.24No.1 Issue: 1 Pages: 30-35

    • DOI

      10.4318/tjg.2013.0558

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of eicosapentaenoic acid concentrations in plasma between patients with ischemic stroke and control subjects2013

    • Author(s)
      Y.Ikeya, N.Fukuyama, W.Kitajima, Y.Ogushi, H.Mori
    • Journal Title

      Nutrition

      Volume: Volume29,Issue1 Issue: 1 Pages: 127-131

    • DOI

      10.1016/j.nut.2012.05.003

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs2012

    • Author(s)
      Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M.
    • Journal Title

      Cardiovasc Drugs Ther.

      Volume: 26 Issue: 3 Pages: 217-226

    • DOI

      10.1007/s10557-012-6381-5

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Investigation of Bacteremia due to Aeromonas Species and Comparison with That due to Enterobacteria in Patients with Liver Cirrhosis2011

    • Author(s)
      T.Shizuma, C.Tanaka, H.Mori, N.Fukuyama
    • Journal Title

      Gastroenterology Research and Practice

      Volume: Article ID 930826 Pages: 4-4

    • DOI

      10.1155/2011/930826

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effects of four molecular-weight fractions of Kurozu against dextran sulfate sodium-induced experimental colitis2011

    • Author(s)
      Shizuma T, Nagano M, Fujii A, Mori H, Fukuyama N
    • Journal Title

      Turk J Gastroenterol

      Volume: 22(4) Issue: 4 Pages: 376-381

    • DOI

      10.4318/tjg.2011.0239

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protective effects of fermented rice vinegar sediment (Kurozu moromimatsu) in a diethylnitrosamine-induced hepatocellular carcinoma animal model2011

    • Author(s)
      Shizuma T, Ishiwata K, Nagano M, Mori H, Fukuyanla N
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Issue: 1 Pages: 31-35

    • DOI

      10.3164/jcbn.10-112.

    • NAID

      130004879259

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Naoto Fukuyama : Protective effects of Kurozu and Kurozu moromimatsu on dextran sulfate sodium - induced experimental colitis2011

    • Author(s)
      Toru Shizuma; Kazuo Ishiwata; Masanobu Nagano; Hidezo Mori
    • Journal Title

      Dig Dis Sci

      Volume: 56(5) Issue: 5 Pages: 1387-92

    • DOI

      10.1007/s10620-010-1432-x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of gastrointestinal injury and blood flow of small bowel during low-dose aspirin administration2011

    • Author(s)
      Nishida U, Kato M, Nishida M, Kamada G, Ono S, Shimizu Y, Fujimori R, Asaka M
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 48 Issue: 3 Pages: 245-250

    • DOI

      10.3164/jcbn.10-112

    • NAID

      130004879252

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] THE ANALYSIS OF THE RISK OF CARDIOEMBOLISM IN THE ELDERLY IN GROUP HOME2014

    • Author(s)
      Hidezo Mori, Kikue Todoroki, Yoshimori Ikeya, Etsuro Tanaka, Naoto Fukuyama
    • Organizer
      29th International Conference of Alzheimer's Disease International
    • Year and Date
      2014-05-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Concepts and Limitations of Coronary Flow Reserve to Evaluate Myocardial Ischemia2014

    • Author(s)
      盛 英三
    • Organizer
      第78回日本循環器学会学術集会(JCS2014)
    • Place of Presentation
      東京国際フオーラム
    • Year and Date
      2014-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] グループホーム入居高齢者における多価不飽和脂肪酸値と心機能の解析2014

    • Author(s)
      裏木喜久江、池谷義守、田中越郎、福山直人、盛英三
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Year and Date
      2014-03-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Visual approaches to vascular cognitive impairment by synchrotron radiation microangiography of perforating branches of cerebral arteries2014

    • Author(s)
      H. Mori
    • Organizer
      ECR
    • Place of Presentation
      Austria Center Vienna
    • Year and Date
      2014-03-06
    • Related Report
      2013 Final Research Report
  • [Presentation] グループホームにおける心原性脳梗塞リスクの解析2014

    • Author(s)
      裏木喜久江、池谷義守、福山直人、田中越郎、盛英三
    • Organizer
      第29回日本静脈経腸栄養学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-02-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Visual approaches to vascular cognitive impairment by synchrotron radiation microangiography of perforating branches of cerebral arteries2014

    • Author(s)
      H. Mori
    • Organizer
      ECR 2014
    • Place of Presentation
      Austria Center Vienna
    • Related Report
      2013 Annual Research Report
  • [Presentation] UNSOLVED ISSUES OF CORONARY CIRCULATION LEFT BY THE CLASSICS OF SYSTEM PHYSIOLGY2013

    • Author(s)
      盛英三
    • Organizer
      第46回河口湖心臓討論会
    • Place of Presentation
      宮城蔵王ロイヤルホテル
    • Year and Date
      2013-08-04
    • Related Report
      2013 Final Research Report
  • [Presentation] グループホームに入居する認知症高齢者における脳梗塞リスクの解析2013

    • Author(s)
      裏木喜久江、池谷義守、田中千陽、若菜宣明、本間和宏、田中越郎、福山直人、盛英三
    • Organizer
      第55回日本老年医学会学術集会.2013
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 在宅およびグループホームにおけるターミナルケアに関する研究―2005年7月~2013年1月までの34例―2013

    • Author(s)
      福山直人、田中千陽、盛英三
    • Organizer
      第55回日本老年医学会学術集会.2013
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2013-06-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Angiographic visualization of perforating branches of cerebral arteries toward pathophysiological evaluation of vascular cognitive impairment2013

    • Author(s)
      H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyanla
    • Organizer
      The 7th World Congress on Controversies in Neurology (CONy) Istanbul
    • Place of Presentation
      Turkey
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] The evaluation for intracranial small vessels by X-ray radiographic system using a rotating cerium-anode2013

    • Author(s)
      Chiharu Tanaka, Yoshimori Ikeya, Toru Shizuma, Naoto Fukuyama, Hidezo Mori
    • Organizer
      ECR
    • Place of Presentation
      Austria Center Vienna
    • Year and Date
      2013-03-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌動物モデルを用いた、黒酢もろみ末の抗腫瘍効果2013

    • Author(s)
      静間徹、石渡一夫、田中千陽、盛英三、長野正信、福山直人
    • Organizer
      第16回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2013-01-12
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] The evaluation for intracranial small vessels by X-ray radiographic system using a rotating cerium- anode2013

    • Author(s)
      Chiharu Tanaka, Yoshimori Ikeya, Toru Shizuma, Naoto Fukuyama, Hidezo Mori
    • Organizer
      ECR2013
    • Place of Presentation
      Austria Center Vienna
    • Related Report
      2012 Research-status Report
  • [Presentation] 次世代光源を用いた糖尿病性微小循環障害の低侵襲・早期診断法の開発2012

    • Author(s)
      盛英三
    • Organizer
      第2回コンパクトERLサイエンスワークショプ 高エネルギー加速器研究機構
    • Place of Presentation
      研究本館小林ホール
    • Year and Date
      2012-07-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 回転セリウム陽極微小血管造影法を用いた心筋貫通枝および脳穿通枝の描出2012

    • Author(s)
      田中千陽、福山直人、盛英三
    • Organizer
      第54回日本老年医学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] グループホームにおける生活能力拡大志向型介護法の介入効果に関する前向き研究2012

    • Author(s)
      福山直人、田中千陽、盛英三
    • Organizer
      第54回日本老年医学会学術集会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2012-06-28
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Development of in-hospital x-ray radiographic system using rotating cerium anode for coronary and cerebral microangiography2012

    • Author(s)
      H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyama
    • Organizer
      ECR
    • Place of Presentation
      Austria Center Vienna
    • Year and Date
      2012-03-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Angiographic visualization of perforating branches of cerebral arteries toward pathophysiological evaluation of vascular cognitive impairment2012

    • Author(s)
      H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyama
    • Organizer
      The 7th World Congress on Controversies in Neurology (CONy)
    • Place of Presentation
      Swissotel The Bosphorus, Istanbul, Turkey
    • Related Report
      2012 Research-status Report
  • [Presentation] 次世代光源を用いた糖尿病性微小循環障害の低侵襲・早期診断法の開発2012

    • Author(s)
      盛英三
    • Organizer
      第2回コンパクトERLサイエンスワークショプ
    • Place of Presentation
      高エネルギー加速器研究機構 研究本館小林ホール
    • Related Report
      2012 Research-status Report
  • [Presentation] Tryptophan ameliorates dextran sulfate sodium-induced colitis in an animal model2011

    • Author(s)
      Shizuma T, Ishiwata K, Tanaka C, Mori H, Nagano M, Fukuyama N
    • Organizer
      33nd ESPEN Congress on Clinical Nutrition and Metabolism 2011
    • Place of Presentation
      Gothenburg, Septenlber
    • Year and Date
      2011-09-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Fingertip Synchrotron Radiation Angiography for Prediction of Diabetic Microangiopathy2011

    • Author(s)
      T. Fujii, N. Fukuyama, Y. Ikeya, Y. Shinozaki, T. Tanabe, K. Unletani and H. Mori
    • Organizer
      5th Kuala Lumpur International Conference on Biomedical Engineering
    • Year and Date
      2011-06-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病性微小血管障害の診断~指尖部放射光血管造影法を用いて~2011

    • Author(s)
      田中千陽、盛英三、福山直人
    • Organizer
      第53回日本老年医学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2011-06-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 在宅診療における医療に関する研究2011

    • Author(s)
      田中千陽、盛英三、福山直人
    • Organizer
      第53回日本老年医学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2011-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Fingertip Synchrotron Radiation Angiography...2011

    • Author(s)
      T.Fujii, N.Fukuyama, Y.Ikeya, H.Mori, et al.
    • Organizer
      BIOMED2011
    • Place of Presentation
      マレーシア クアラルンプール
    • Related Report
      2011 Research-status Report
  • [Presentation] Concepts and Limitations of Coronary Flow Reserve to Evaluate Myocardial Ischemia

    • Author(s)
      盛 英三
    • Organizer
      第78回日本循環器学会学術集会(JCS2014)
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] グループホーム入居高齢者における多価不飽和脂肪酸値と心機能の解析

    • Author(s)
      軣木喜久江、池谷義守、田中越郎、福山直人、盛英三
    • Organizer
      第91回 日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] グループホームにおける心原性脳梗塞リスクの解析

    • Author(s)
      軣木喜久江、池谷義守、福山直人、田中越郎、盛英三
    • Organizer
      第29回日本静脈経腸栄養学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] グループホームに入居する認知症高齢者における脳梗塞リスクの解析

    • Author(s)
      軣木喜久江、池谷義守、田中千陽、 若菜宣明、本間和宏、田中越郎、福山直人、盛 英三
    • Organizer
      第55回日本老年医学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 在宅およびグループホームにおけるターミナルケアに関する研究ー2005年7月~2013年1月までの34例ー

    • Author(s)
      福山直人、田中千陽、盛英三
    • Organizer
      第55回日本老年医学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Angiographic visualization of perforating branches of cerebral arteries toward pathophysiological evaluation of vascular cognitive impairment

    • Author(s)
      H. Mori, C. Tanaka, Y. Ikeya, T. Fujii, T. Shizuma, N. Fukuyama
    • Organizer
      The 7th World Congress on Controversies in Neurology (CONy)
    • Place of Presentation
      Swissotel The Bosphorus, Istanbul
    • Related Report
      2013 Annual Research Report
  • [Presentation] UNSOLVED ISSUES OF CORONARY CIRCULATION LEFT BY THE CLASSICS OF SYSTEM PHYSIOLGY

    • Author(s)
      盛英三
    • Organizer
      第46回 河口湖心臓討論会
    • Place of Presentation
      宮城蔵王ロイヤルホテル
    • Related Report
      2012 Research-status Report
  • [Book] 新訂 生理学実習書 13章テクニカルノート 13-8 実験データの統計処理2013

    • Author(s)
      静間徹、福山直人、田中千陽、軣木喜久江、盛英三
    • Total Pages
      20
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Book] Colitis2012

    • Author(s)
      M.Fukata, T.Shizuma, H.Mori, et al.
    • Total Pages
      16
    • Publisher
      InTech
    • Related Report
      2011 Research-status Report
  • [Book] Gene Therapy Applications2011

    • Author(s)
      Chunsheng Kang, T.Shizuma, H.Mori, et al.
    • Total Pages
      14
    • Publisher
      InTech
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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