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Development of new technology for the analysis of and pharmacological effects on intracellular and intercellular conduction, using pulse-driven MI sensor operated at room temperature

Research Project

Project/Area Number 23659397
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionNagoya University

Principal Investigator

NAKAYAMA Shinsuke  名古屋大学, 医学系研究科, 准教授 (30192230)

Co-Investigator(Kenkyū-buntansha) UCHIYAMA Tsuyoshi  名古屋大学, 工学研究科, 准教授 (00203555)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords磁気センサー / 非侵襲 / 上部消化管 / ペースメーカー電流 / 再生医療 / ペースメーカ電流 / 再生医療応用
Research Abstract

Magnetic sensors constructed with a magnetic amorphous wire surrounded by a pickup-coil, are referred to as MI sensor. In this study, a pair of MI magnetic sensors were operated by applying electric current through a CMOS inverter circuit, and were used as a gradio-sensor by using a differential amplifier circuit. During musculature preparations isolated from the gut of animals were superfused with an extracellular solution, and spontaneous magnetic waves were successfully recorded. In some experiments, electric field potentials were simultaneously recorded by suing extracellular electrodes along with magnetic waves.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (13 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Assessment of gastric emptying and duodenal motility upon ingestion of liquid meal using rapid magnetic resonance imaging2012

    • Author(s)
      Teramoto H, Shimizu T, Yogo H, Nishimiya Y, Hori S, Kosugi T, Nakayama S
    • Journal Title

      Experimental Physiology

      Volume: 97 Pages: 516-524

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency analysis may distinguish the effects of calcium antagonists on mechanical and electrical activity2012

    • Author(s)
      Nakayama S
    • Journal Title

      Neurogastroenterology and Motility

      Volume: 24 Pages: 397-397

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous cardiac troponin T modulates Ca2+-mediated smooth muscle contraction2012

    • Author(s)
      Kajioka S, Takahashi-Yanaga F, Shahab N, Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S
    • Journal Title

      Scientific Reports

      Volume: 2 Pages: 979-979

    • URL

      http://www.nature.com/srep/2012/121214/srep00979/full/srep00979.html

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency analysis may distinguish the effects of calcium antagonists on mechanical and electrical activity2012

    • Author(s)
      Nakayama S.
    • Journal Title

      Neurogastroenterology and Motility

      Volume: 24 Issue: 4 Pages: 397-397

    • DOI

      10.1111/j.1365-2982.2012.01882.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction.2012

    • Author(s)
      Kajioka S
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 979-979

    • DOI

      10.1038/srep00979

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulse-driven magnetoimpedance sensor detection of biomagnetic fields in musculatures with spontaneous electric activity2011

    • Author(s)
      Nakayama S, Atsuta S, Shinmi T, Uchiyama T
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 27 Pages: 34-39

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of spontaneous oscillatory magnetic field of guinea-pig stomach muscle preparation using pico-Tesla resolution amorphous wire magneto-impedance sensor2011

    • Author(s)
      Uchiyama T, Mohri K, Nakayama S.
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 47 Pages: 3070-3073

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulse-driven magnetoimpedance sensor detection of cardiac magnetic activity2011

    • Author(s)
      Nakayama S, Sawamura K, Mohri K, Uchiyama T.
    • Journal Title

      PLoS ONE

      Volume: 6(10)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diphosphate regulation of ATP-sensitive potassium channel in human urinary bladder smooth muscle cells2011

    • Author(s)
      Kajioka S, Shahab N, Asano,H, Morita H, Sugihara M, Takahashi-Yanaga F, Yoshihara T, Nakayama S, Seki N, Naito S
    • Journal Title

      Journal of Urology

      Volume: 186 Pages: 736-744

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orexins stimulate the 'appetite' of the gut.2011

    • Author(s)
      Nakayama S
    • Journal Title

      Journal of Physiology

      Volume: 589 Pages: 5907-5908

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulse-driven magnetoimpedance sensor detection of biomagnetic fields in musculatures with spontaneous electric activity.2011

    • Author(s)
      Nakayama, S., Atsuta, S., Shinmi, T. & Uchiyama, T.
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 27 Pages: 34-39

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pulse-driven magnetoimpedance sensor detection of cardiac magnetic activity.2011

    • Author(s)
      Nakayama, S., Sawamura, K., Mohri, K. & Uchiyama, T.
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Cooperative gut motility requires the network of pacemaker cells2013

    • Author(s)
      中山晋介、谷口 瑞樹、Habibul B. Shozib
    • Organizer
      第90回日本生理学会・入澤宏・彩記念(入澤賞)シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Make biomagnetic fields realistic :Application of pulse-driven magnetoimpedance sensor to physiology2013

    • Author(s)
      中山晋介、熱田諭志、近藤正夫、内山剛
    • Organizer
      第90回日本生理学会・日本生物物理学会連携シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Make biomagnetic fields realistic :Application of pulse-driven magnetoimpedance sensor to physiology2013

    • Author(s)
      中山晋介
    • Organizer
      第90回日本生理学会・日本生物物理学会連携シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cooperative gut motility requires the network of pacemaker cells2013

    • Author(s)
      中山晋介
    • Organizer
      第90回日本生理学会・入澤宏・彩記念(入澤賞)シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Spatial characterization of spontaneous electric activity in the ileum of mice using arrayed microelectrodes with increased surface area2012

    • Author(s)
      Nakayama S, Taniguchi M, Shozib HB, Sawamura K
    • Organizer
      7th International Symposium on Interstitial Cells of Cajal
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2012-09-03
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] A MEG measurement using pico-Tesla sensitivity amorphous wire magneto-impedance sensor for brain activity evaluation2012

    • Author(s)
      Uchiyama T, Mohri K, Nakayama S
    • Organizer
      A MEG measurement using pico-Tesla sensitivity amorphous wire magneto-impedance sensor for brain activity evaluation
    • Place of Presentation
      Moscow, Russia
    • Year and Date
      2012-08-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 高速MRIによる流動食摂取後の胃排出・十二指腸運動の評価2012

    • Author(s)
      寺本英巳、谷口瑞毅、清水利恭、小杉隆司、中山晋介
    • Organizer
      第54回日本平滑筋学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 磁気インピーダンスセンサーによる平滑筋細胞組織計測と最近の高精度化2012

    • Author(s)
      中山晋介、熱田諭志、内山剛
    • Organizer
      第54回日本平滑筋学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Biomagnetic waves measured in musculatures using a pulse-driven magnetoimpedance sensor2012

    • Author(s)
      中山晋介、熱田諭志、内山剛
    • Organizer
      第89回日本生理学会総会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] MI素子による高性能グラジオメータの開発と細胞組織活動計測への応用2012

    • Author(s)
      内山剛、熱田諭志、中山晋介
    • Organizer
      マグネティックスリニアドライブ合同研究会
    • Place of Presentation
      金沢
    • Year and Date
      2012-02-22
    • Related Report
      2012 Final Research Report
  • [Presentation] パルス励磁タイプ超高感度磁気インピーダンスセンサーによる生体磁気活動計測2011

    • Author(s)
      熱田諭志、内山剛、中山晋介
    • Organizer
      第53回日本平滑筋学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-08-04
    • Related Report
      2012 Final Research Report
  • [Presentation] パルス励磁タイプ超高感度磁気インピーダンスセンサーによる生体磁気活動計測

    • Author(s)
      熱田諭志、内山剛、中山晋介
    • Organizer
      日本平滑筋学会(第53回)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Biomagnetic waves measured in musculatures using a pulse-driven magnetoimpedance sensor

    • Author(s)
      Nakayama, S., Atsuta, A., Uchiyama, T.)
    • Organizer
      日本生理学会(第89回)
    • Place of Presentation
      松本
    • Related Report
      2011 Research-status Report
  • [Book] Network of gut pacemakercells: spatio-temporal evaluation of electrical activity by use of microelectrode array. In: Modern Pacemakers - Present and Future, Chapter 242011

    • Author(s)
      Nakayama S, Taniguchi M, Liu H-N
    • URL

      http://www.intechopen.com/articles/show/title/network-of-gut-pacemaker-cells-spatio-temporal-evaluation-of-electrical-activity-by-use-of-microelec

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/read0011077/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 磁気検出装置2012

    • Inventor(s)
      内山剛、中山晋介、熱田諭志
    • Industrial Property Rights Holder
      名古屋大学、フジデノロ
    • Filing Date
      2012-03-05
    • Related Report
      2012 Final Research Report
    • Overseas

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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