| Project/Area Number |
23659398
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
TERAI Shuji 山口大学, 大学院・医学系研究科, 准教授 (00332809)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Naoki 山口大学, 大学教育機構, 講師 (90448283)
TAKAMI Taro 山口大学, 大学院・医学系研究科, 講師 (60511251)
FUJISAWA Koichi 山口大学, 大学院・医学系研究科, 助教 (00448284)
SAKAIDA Isao 山口大学, 大学院・医学系研究科, 教授 (80263763)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | NASH / 肝障害 / サーカディアンリズム / 脂肪肝 / 肝再生 / サーカデイアンリズム |
|---|
| Research Abstract |
Medaka with HFD showed high NASH activity score (NAS), suggesting that circadian rhythm change is related to NASH progression. The light system is closely related with chronic inflammation by light stimulation. Collaboration with Oklahoma university, we found that NASH medaka developed diabetic nephropathy. These data showedmedaka fish model is useful to analyze the mechanism of NASH and nephropathyand to develop a new chronotherapy.
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