Impact of CD36 molecule affecting insulin resistance in patients with HCV-related chronic liver disease

• Project/Area Number: 23659399
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kagawa University
• Principal Investigator: TAKASHI Himoto 香川大学, 医学部附属病院, 講師 (20325343)
• Co-Investigator(Kenkyū-buntansha): HABA Reiji 香川大学, 医学部付属病院病理診断科, 准教授 (90304584) ; MASUGATA Hisashi 香川大学, 医学部付属病院総合診療科, 講師 (70263910) ; MASAKI Tsutomu 香川大学, 医学部消化器・神経内科, 教授 (30335848) ; SENDA Shoichi 香川大学, 医学部付属病院総合診療科, 教授 (30145049)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肝脂肪化 / Ｃ型肝炎ウイルス / インスリン抵抗性 / 肥満 / ＣＤ36 / oxidized LDL / CD36 / OxLDL / CD14 / C型肝炎ウイルス / ＣＤ36分子

Research Abstract

The primary purpose of this study was to investigate the role of CD36 in the pathogenesis of insulin resistance and hepatic steatosis caused by chronic HCV infection. Serum soluble CD36 levels reflected the severity of CD36 expression on Kupffer cells in patients with HCV-related chronic liver disease (CLD-C). Soluble CD36 levels were significantly associated with obesity in patients with CLD-C. However, circulating soluble CD36 concentrations were independent of insulin resistance and hepatic steatosis in patients with CLD-C.

Research Products

• [Journal Article] Investigation of the factors associated with circulating soluble CD36 levels in patients with HCV-related chronic liver disease (2013)
  • Author(s): Himoto T, tani J, Miyoshi H, et al.
  • Journal Title: Diabetol Metab Syndr Volume: (Epub)
• [Journal Article] Investigation of the factors associated with circulating soluble CD36 levels in patients with HCV-related chronic liver disease (2013)
  • Author(s): Himoto T,Tani J, Miyoshi H, et al.
  • Journal Title: Diabetol Metab Syndr Volume: 5 Pages: 51-60
• [Presentation] oxidizedLDL およびCD36 を標的としたC型慢性肝疾患患者におけるインスリン抵抗性の解明 (2013)
  • Author(s): 樋本尚志、谷 丈二、三好久昭, 他
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] Contribution of oxidized LDL and CD36 to insulin resistance in patients with HCV-related chronic liver disease (2013)
  • Author(s): Himoto T, Tani J, Miyoshi H, et al.
  • Organizer: 第5回前糖尿病とメタボリックシンドロームに関する国際会議
  • Place of Presentation: ウイーン、オーストリア
• [Presentation] Contribution of oxidized LDL and CD36 to insulin resistance in patients with HCV-related chronic liver disease (2013)
  • Author(s): Himoto T, Tani J, Miyoshi H, et al.
  • Organizer: 5th international congress on prediabetes and Metabolic syndrome
  • Place of Presentation: Vienna, Austria
• [Presentation] oxidized LDLおよびＣＤ36を標的としたＣ型慢性肝疾患患者におけるインスリン抵抗性の解明 (2013)
  • Author(s): 樋本尚志、谷 丈二、三好久昭 他
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] 第５回前糖尿病とメタボリックシンドロームに関する国際会議 (2013)
  • Author(s): Takashi Himoto,Joji Tani, Hisaaki Miyoshi, Michio Inukai,Hisashi Masugata, Fuminori Goda, Reiji Haba, Shoichi Senda, Tsutomu Masaki
  • Organizer: Contribution of oxidized LDL and CD36 to insulin resistance in patients with HCV-related chronic liver disease.
  • Place of Presentation: ウイーン，オーストリア
• [Presentation] oxidized LDLおよびCD36を標的としたC型慢性肝疾患患者におけるインスリン抵抗性の解明 (2013)
  • Author(s): 樋本尚志，谷 丈二，三好久昭，米山弘人，出口章広，正木 勉
  • Organizer: 第４９回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] C型慢性肝疾患患者におけるCD36分子を標的としたインスリン抵抗性の解明 (2012)
  • Author(s): 樋本尚志、谷 丈二、三好久昭, 他
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] C型慢性肝疾患患者におけるCD36分子を標的としたインスリン抵抗性の解明 (2012)
  • Author(s): 樋本尚志，谷 丈二，三好久昭，米山弘人，出口章広，正木 勉
  • Organizer: 第４８回日本肝臓学会総会
  • Place of Presentation: 金沢