New biomarker discovery for patients with pulmonary hypertension

• Project/Area Number: 23659408
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Tohoku University
• Principal Investigator: SATOH Kimio 東北大学, 高等教育開発推進センター, 准教授 (80436120)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺高血圧 / 低酸素 / 酸化ストレス / バイオマーカー / 低酸素環境 / 炎症 / 血管平滑筋細胞 / 臨床応用 / サイクロフィリンA / Rho-kinase

Research Abstract

Pulmonary hypertension (PH) is associated with hypoxic exposure, enhanced production of reactive oxygen species (ROS) and proliferation of vascular smooth muscle cells (VSMC). In this study, we tested our hypothesis that cyclophilin A (CyPA) contributes to pulmonary vascular remodeling in patients with PH. Plasma CyPA levels were significantly elevated in patients with PH than in those without PH or healthy controls. Moreover, plasma CyPA levels increased according to the quartiles of pulmonary vascular resistance. Medical treatments reduced plasma CyPA levels in patients with PH. Finally, event-free curve revealed that high plasma CyPA predicted poor outcome (death or lungtransplantation). These results indicate that plasma CyPA is a novel biomarker for patients with PH.

Research Products

• [Journal Article] Plasma cyclophilin A is a novel biomarker for coronary artery disease (2013)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, MiuraY, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S, Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
  • Journal Title: Circ J Volume: 77 Pages: 447-455
  • NAID: 10031138924
  • Peer Reviewed
• [Journal Article] Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease (2013)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S,Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
  • Journal Title: Circ J Volume: 77 Issue: 2 Pages: 447-455
  • DOI: 10.1253/circj.cj-12-0805 10.1253/circj.CJ-12-0805
  • NAID: 10031138924
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Dipeptidyl Peptidase-4 Inhibitors (2013)
  • Author(s): 佐藤公雄 (Kimio Satoh)
  • Journal Title: Circ J Volume: 77 Issue: 5 Pages: 1156-1157
  • DOI: 10.1253/circj.cj-13-0064 10.1253/circj.CJ-13-0064
  • NAID: 10031151374
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomography Is Superior to Intravascular Ultrasound for Diagnosis of Distal-Type Chronic Thromboembolic Pulmonary Hypertension (2013)
  • Author(s): Tatebe S
  • Journal Title: Circ J Volume: 77 Issue: 4 Pages: 1081-1083
  • DOI: 10.1253/circj.cj-12-1493 10.1253/circj.CJ-12-1493
  • NAID: 130003361592
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension (2012)
  • Author(s): Sugimura K, Fukumoto Y, Satoh K, Nochioka K, Miura Y, Aoki T, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H
  • Journal Title: Circ J Volume: 76 Pages: 485-488
  • NAID: 10030036102
  • Peer Reviewed
• [Journal Article] Clinical significance of reactivepost-capillary pulmonary hypertension inpatients with left heart disease (2012)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Miyamichi-Yamamoto S, Aoki T, Miura Y, Nochioka K, Satoh K, Shimokawa H
  • Journal Title: Circ J Volume: 76 Pages: 1235-1244
  • Peer Reviewed
• [Journal Article] Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular target (2012)
  • Author(s): Satoh K, Fukumoto Y, Nakano M, Kagaya Y, Shimokawa H
  • Journal Title: J Cardiovasc Pharmacol Volume: 58 Pages: 570-574
  • Peer Reviewed
• [Journal Article] Current perspectives on protective rolls of erythropoietin in cardiovascular system - Erythropoietin receptor as a novel therapeutic target - (2012)
  • Author(s): Kagaya Y, Asaumi Y, Wang W, Takeda M, Nakano M, Satoh K, Fukumoto Y, Shimokawa H
  • Journal Title: Tohoku J Exp Med Volume: 227 Pages: 83-91
  • Peer Reviewed
• [Journal Article] Current Perspectives on Protective Roles of Erythropoietin in Cardiovascular System: Erythropoietin Receptor as a Novel Therapeutic Target (2012)
  • Author(s): Kagaya Y, Asaumi Y, Wang W, Takeda M, Nakano M, Satoh K, Fukumoto Y, Shimokawa H.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 227 Issue: 2 Pages: 83-91
  • DOI: 10.1620/tjem.227.83
  • NAID: 10030779568
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Clinical Significance of Reactive Post-Capillary Pulmonary Hypertension in Patients With Left Heart Disease (2012)
  • Author(s): Tatebe S
  • Journal Title: Circ J Volume: 76 Issue: 5 Pages: 1235-1244
  • DOI: 10.1253/circj.cj-11-1288 10.1253/circj.CJ-11-1288
  • NAID: 10030132858
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension (2012)
  • Author(s): Sugimura K
  • Journal Title: Circ J Volume: 76 Issue: 2 Pages: 485-488
  • DOI: 10.1253/circj.cj-11-1217 10.1253/circj.CJ-11-1217
  • NAID: 10030036102
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular target (Review). (2012)
  • Author(s): Kimio Satoh
  • Journal Title: Journal of Cardiovascular Pharmacology Volume: 58 Pages: 570-574
  • DOI: 10.1097/fjc.0b013e318235e7bb
  • Peer Reviewed
• [Journal Article] Prognostic impact of myocardial interstitial fibrosis innon-ischemic heart failure - (2011)
  • Author(s): Aoki T, Fukumoto Y, Sugimura K, Oikawa M, Satoh K, Nakano M, Nakayama M, Shimokawa H
  • Journal Title: Comparisonbetween preserved and reduced ejectionfraction heart failure- Circ J Volume: 75 Pages: 2605-2613
  • Peer Reviewed
• [Journal Article] Intensive immunospuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connectivetissue disease (2011)
  • Author(s): Miyamichi-Yamamoto S, Fukumoto Y, Sugimura K, Ishii T, Satoh K, Miura U, Tatebe S, Nochioka K, Aoki T, Do.e Zhulanqiqige, Shimokawa H
  • Journal Title: Circ J Volume: 75 Pages: 2668-2674
  • Peer Reviewed
• [Journal Article] Indispensable roles ofOX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis ofspontaneous pulmonary hypertension (2011)
  • Author(s): Rabieyousefi M, Soroosh P, Satoh K, Date1F, Ishii N, Yamashita M, Oka M, McMurtryIF, Shimokawa H, Nose M, Sugamura K,Ono M
  • Journal Title: BMC Immunology Volume: 12 Pages: 67-79
  • Peer Reviewed
• [Journal Article] Vascular-derived reactive oxygen species for homeostasis and diseases (2011)
  • Author(s): Satoh K, Shimokawa H
  • Journal Title: Nitric Oxide Volume: 25 Pages: 211-215
  • Peer Reviewed
• [Journal Article] Rho-kinase: Important new therapeutic target in cardiovascular diseases (2011)
  • Author(s): Satoh K, Fukumoto Y, Shimokawa H
  • Journal Title: Am J Physiol Volume: 301
  • Peer Reviewed
• [Journal Article] Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice. (2011)
  • Author(s): Satoh K, et al.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 31 Pages: 1116-1123
  • DOI: 10.1161/atvbaha.110.214601
  • Peer Reviewed
• [Journal Article] Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. (2011)
  • Author(s): Nigro P, Satoh K, et al.
  • Journal Title: J Exp Med. Volume: 208 Pages: 53-66
  • DOI: 10.1084/jem.20101174
  • Peer Reviewed
• [Journal Article] Rho-kinase:Important new therapeutic target in cardiovascular diseases (2011)
  • Author(s): Satoh K, Fukumoto Y, Shimokawa H
  • Journal Title: Am J Physiol. Volume: 301 Pages: 287-296
  • DOI: 10.1152/ajpheart.00327.2011
  • Peer Reviewed
• [Journal Article] Vascular-derived reactive oxygen species for homeostasis and diseases (2011)
  • Author(s): Satoh K, Shimokawa H
  • Journal Title: Nitric Oxide Volume: 25 Pages: 211-215
  • DOI: 10.1016/j.niox.2011.04.005
  • Peer Reviewed
• [Journal Article] Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension (2011)
  • Author(s): Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M,McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M.
  • Journal Title: BMC Immunol. Volume: 12 Pages: 67-67
  • DOI: 10.1186/1471-2172-12-67
  • Peer Reviewed
• [Journal Article] Intensive Immunosuppressive Therapy Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Pulmonary Arterial Hypertension Associated With Connective Tissue Disease. (2011)
  • Author(s): Miyamichi-Yamamoto S, Fukumoto Y, Sugimura K, Ishii T, Satoh K, Miura Y, Tatebe S, Nochioka K, Aoki T, Do E Z, Shimokawa H.
  • Journal Title: Circ J. Volume: 75 Pages: 2668-2674
  • NAID: 10030032490
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Myocardial Interstitial Fibrosis in Non-Ischemic Heart Failure. (2011)
  • Author(s): Aoki T, Fukumoto Y, Sugimura K, Oikawa M, Satoh K, Nakano M, Nakayama M, Shimokawa H.
  • Journal Title: Circ J. Volume: 75 Pages: 2605-2613
  • Peer Reviewed
• [Journal Article] Optical coherence tomography is superior to intravascular ultrasound for diagnosis of distal-type chronic thromboembolic pulmonaryhypertension
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Miura M, Yamamoto S, Yaoita N, Satoh K, Shimokawa H
  • Journal Title: Circ J Volume: (in press)
  • Peer Reviewed
• [Presentation] Plasma cyclophilin A is a novel biomarker for oxidative stress and coronary artery disease (2013)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Takagi Y, Tsuburaya R, Itoh Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Current status of chronic heart failure with adult congenital heart disease in Japan (2013)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Yamamaoto S, Satoh K, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Recent research progress on the role of Rho-kinase pathway in the pathogenesis of pulmonary arterial hypertension -From Bench to Bedside- (2013)
  • Author(s): Fukumoto Y, Sugimura K, Shimizu T, Qiqige Z, Yamamoto S, Tatebe S, Aoki T, Nochioka K, Miura Y, Satoh K, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Spontaneous development of arrhythmogenic right ventricular cardiomyopathy in mice overexpressing dominant-negative Rho-kinase in cardiovascular system (2013)
  • Author(s): Ellawindy A, Satoh K, Tanaka S, Ikeda S, Shimizu T, Noda K, Fukumoto Y, Kobayashi K, Nakayama K, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Plasma cyclophilin A level is a novel biomarker of vasospastic angina (2013)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Takagi Y, Tsuburaya R, Itoh Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Plasma cyclophilin A as a novel biomarker for pulmonary hypertension in humans (2013)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Ito H, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension in rats (2013)
  • Author(s): Al-Mamun E, Satoh K, Tanaka S, Shimizu T, Nergui S, Fukumoto Y, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Impact of positive myocardial biopsy on ventricular function and prognosis in patients with cardiac sarcoidosis (2013)
  • Author(s): Miura Y, Fukumoto Y, Sugimura K, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Satoh K, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Enhanced Rho-kinase activity in circulating leukocytes in patients with heart failure (2013)
  • Author(s): Qiqige Z, Fukumoto Y, Sugimura K, Miura Y, Tatebe S, Yamamoto S, Aoki T, Nochioka K, Satoh K, Nergui S, Kondoh M, Nakano M, Wakayama Y, Fukuda K, Nihei T, Takahashi J, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice (2013)
  • Author(s): Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Shimokawa H
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 肺高血圧の重症度と予後予測のための新規バイオマーカー・サイクロフィリンA (2013)
  • Author(s): 佐藤公雄、福本義弘、杉村宏一郎、三浦裕、青木竜男、後岡広太郎、建部俊介、山本沙織、清水亨、矢尾板信裕、中村一文、伊藤浩、下川宏明
  • Organizer: 第42回日本心脈管作動物質学会学術集会
  • Place of Presentation: 奈良
• [Presentation] Plasma Cyclophilin A is a novel biomarker for oxidative stress and coronary artery disease. (2013)
  • Author(s): 佐藤公雄 (Kimio Satoh)
  • Organizer: 日本循環器学会総会 (シンポジウム)
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Spontaneous Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Mice Over-expressing Dominant-Negative Rho-kinase in the Cardiovascular System (2013)
  • Author(s): Alia Ellawindy
  • Organizer: 日本循環器学会総会 (International Young Investigator's Award)
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Plasma Cyclophilin A Level Is a Novel Biomarker of Vasospastic Angina (2013)
  • Author(s): 佐藤公雄 (Kimio Satoh)
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Plasma Cyclophilin A as a Novel Biomarker for Pulmonary Hypertension in Humans (2013)
  • Author(s): 佐藤公雄 (Kimio Satoh)
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 酸化ストレス分泌蛋白CyclophylinAによる肺高血圧促進機構-Rho-kinase系の関与- (2012)
  • Author(s): 佐藤公雄、福本義弘、杉村宏一郎、三浦裕、青木竜男、後岡広太郎、建部俊介、山本沙織、清水亨、下川宏明
  • Organizer: 第1回日本肺循環学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-22
• [Presentation] Percutaneous transluminal pulmonary angioplasty markedly ameliorates pulmonary hemodynamics and long-term prognosis of patients with distal-type chronic thromboembolic pulmonary hypertension (2012)
  • Author(s): Fukumoto Y, Sugimura K, Satoh K, Nochioka K, Miura Y, Aoki T, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: San Francisco, USA
• [Presentation] Remarkable effectiveness of percutaneous transluminal pulmonary angioplasty for hemodynamics and long-term prognosis in patients with distal-type chronic thromboembolic pulmonary hypertension (2012)
  • Author(s): Sugimura K, Fukumoto Y, Satoh K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Munich, Germany
• [Presentation] Plasma cyclophilin A level is a novel biomarker of coronary artery disease (2012)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Takagi Y, Takahashi J, Shimokawa H
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Munich, Germany
• [Presentation] Rho kinase activity in circulating leukocytes as a novel bio marker of heart failure. (#12636) (2012)
  • Author(s): Doe Z, Fukumoto Y, Sugimura K, Miura Y, Tatebe S, Yamamoto, AokiT, Nohicoka K, Satoh K, SuvdN, Kondo M, Nakano M, Wakayama Y, Fukuda K, Nihei T, Kikuchi Y, Takahashi J, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] Spontaneous development of arrhythmogenic right ventricular cardiomyopathy in mice overexpressing dominant-negative Rho-kinase in vascular smooth muscle cells. (#10984) (2012)
  • Author(s): Ellawindy A, Satoh K, Tanaka S, Ikeda S, Shimizu T, Noda K, Fukumoto Y, KobayashiK, NakayamaK,Shimokawa H
  • Organizer: American Heart Association(AHA) Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] Percutaneous transluminalpulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis of patients with distal-type chronic thromboembolic pulmonary hypertension. (#13752) (2012)
  • Author(s): Miura Y, Sugimura K, Fukumoto Y, Satoh K, Nohicoka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] Plasma cyclophilin A as a novel biomarker for pulmonary hypertension in humans. (#11189) (2012)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura M, Nochioka K, Aoki T, TatebeS, Yamamoto S, Shimizu T, Nakamura K, Ito H, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice. (#12299) (2012)
  • Author(s): ShimizuT, Tanaka S, Satoh K, Fukumoto Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] Prognostic significance of enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall in patients with pulmonary hypertension. (#10873) (2012)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Satoh K, MiuraY, Nohicoka K, Aoki T, Yamamoto S, Oikawa-WakayamaM,KagayaY, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] Effects of percutaneous transluminal pulmonary angioplasty in patients with distal-type chromic thromboembolic pulmonary hypertension (2012)
  • Author(s): Sugimura K, Fukumoto Y, Satoh K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Rho-kinase activity in circulating leukocytes as a novel biomarker in patients with chronic heart failure (2012)
  • Author(s): Zhulan Qiqige, Fukumoto Y, Sugimura K, Miura Y, Yamamoto S, Tatebe S, Aoki T, Nochioka K, Satoh K, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice (2012)
  • Author(s): Shimizu T, Tanaka S, Satoh K, Fukumoto Y, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with distal-type chronic thromboembolic pulmonary hypertension (2012)
  • Author(s): Sugimura K, Fukumoto Y, Satoh K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Usefulness of optical coherence tomography in diagnosis of distal-type chronic thromboembolic pulmonary hypertension -comparison with intravascular ultrasound- (2012)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Aoki T, Yamamoto S, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Increased incidence of heart failure in the East Japan Earthquake Disaster (2012)
  • Author(s): Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Yamamoto S, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Plasma cyclophilin a level is a novel biomarker of coronary artery disease (2012)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Osaki S, Takagi Y, Tsuburaya R, Itoh Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Itoh K, Yasuda S, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] Cyclophilin A plays an important role in the pathogenesis of pulmonary arterial hypertension in humans .involvement of rho-kinase pathway- (2012)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Itoh H, Shimokawa H
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 酸化ストレス分泌蛋白Cyclophylin Aによる肺高血圧促進機構-Rho-kinase系の関与- (2012)
  • Author(s): 佐藤公雄、福本義弘、杉村宏一郎、三浦裕、青木竜男、後岡広太郎、建部俊介、中村一文、伊藤浩、下川宏明
  • Organizer: 第12回日本NO学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 新規酸化ストレスマーカーのサイクロフィリンAの冠動脈疾患診断における有用性 (2012)
  • Author(s): 佐藤公雄、福本義弘、杉村宏一郎、三浦裕、後岡広太郎、青木竜男、建部俊介、山本沙織、高木祐介、下川宏明
  • Organizer: 第12回日本NO学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Plasma Cyclophilin A as a Novel Biomarker for Pulmonary Hypertension in Humans (2012)
  • Author(s): 佐藤公雄 (Kimio Satoh)
  • Organizer: 米国心臓病学会議 (AHA 2012)
  • Place of Presentation: オーランド（米国）
  • Invited
• [Presentation] Plasma Cyclophilin A is a novel biomarker for coronary artery disease. (2012)
  • Author(s): 佐藤公雄 (Kimio Satoh)
  • Organizer: 欧州心臓学会議 (ESC 2012)
  • Place of Presentation: ミュンヘン（ドイツ）
  • Invited
• [Presentation] Plasma Cyclophilin A Level Is a Novel Biomarker of Coronary Artery Disease (2012)
  • Author(s): Kimio Satoh, Yoshihiro Fukumoto, Hiroaki Shimokawa et al.
  • Organizer: 日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] Cyclophilin A Plays an Important Role in the Pathogenesis of Pulmonary Arterial Hypertension in Humans - Involvement of Rho-kinase Pathway - (2012)
  • Author(s): Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Hiroaki Shimokawa et al.
  • Organizer: 日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] 新規酸化ストレスマーカー・サイクロフィリンAによる心血管病促進機構 (2011)
  • Author(s): 佐藤公雄、福本義弘、杉村宏一郎、三浦裕、後岡広太郎、青木竜男、建部俊介、山本沙織、下川宏明
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道ルフツ
  • Year and Date: 2011-07-02
• [Presentation] Intensive immunosuppressive therapy improves pulmonary hemodynamics and prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease (2011)
  • Author(s): Yamamoto S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Tatebe S, Nakano M, Oikawa M, Ishii T, Shimokawa H
  • Organizer: European Society of Cardiology 2011
  • Place of Presentation: Paris
• [Presentation] Marked effectiveness of percutaneous transluminal pulmonary angioplasty in patients with distal-type chronic thromboembolic pulmonary hypertension (2011)
  • Author(s): Sugimura K, Fukumoto Y, Satoh K, Miura Y, Tatebe S, Yamamoto S, Shimokawa H
  • Organizer: European Society of Cardiology 2011
  • Place of Presentation: Paris
• [Presentation] Optical coherence tomography is superior to intravenous ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension (2011)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Yamamoto S, Shimokawa H
  • Organizer: European Society of Cardiology 2011
  • Place of Presentation: Paris
• [Presentation] Clinical characteristics and prognosis of patients with post-capillary reactive pulmonary hypertension caused by left heart disease (2011)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Yamamoto S, Shimokawa H
  • Organizer: European Society of Cardiology 2011
  • Place of Presentation: Paris
• [Presentation] Prognostic impact of myocardial fibrosis in patients with heart failure -Comparison between preserved and reduced ejection fraction heart failure- (#12377) (2011)
  • Author(s): Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Nakayama M, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics in patients with distal-type chronic thromboembolic pulmonary hypertension. (#11867) (2011)
  • Author(s): Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Cyclophilin A plays an important role in the pathogenesis of pulmonary arterial hypertension in humans -Involvement of Rho-kinase Pathway- (#10569) (2011)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice. (#9348) (2011)
  • Author(s): Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Cyclophilin A is a novel biomarker for aortic aneurysms and atherosclerotic plaque instability (2011)
  • Author(s): Satoh K, Fukumoto Y, Shimizu T, Suzuki H, Sugimura K, Miura Y, Tatebe S, Miyamichi S, Berk BC, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] New therapeutic strategies for pulmonary hypertension: Rho-kinase inhibitor and balloon pulmonary angioplasty (2011)
  • Author(s): Sugimura K, Fukumoto Y, Satoh K, Miura Y, Tatebe S, Miyamichi S, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Effects of intensive immunosuppressive therapy on pulmonary hemodynamics in patients with pulmonary arterial hypertension associated with connective tissue disease (2011)
  • Author(s): Miyamichi S, Fukumoto Y, Sugimura K, Satoh K, Nakano M, Miura Y, Tatebe S, Oikawa M, Ishii T, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Optical coherence tomography as a novel diagnostic tool for distal-type chronic thromboembolic pulmonary hypertension (2011)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Nakano M, Miura Y, Miyamichi S, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Post-capillary reactive pulmonary hypertension is an adverse prognostic factor in patients with left heart disease (2011)
  • Author(s): Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Miyamichi S, Oikawa M, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice (2011)
  • Author(s): Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Gender difference in prognostic impact of myocardial fibrosis in heart failure patients -Usefulness of myocardial biopsy- (2011)
  • Author(s): Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Tatebe S, Miyamichi S, Nakayama M, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Different brain processing from the right and the left ventricles in humans (2011)
  • Author(s): Suzuki H, Satoh K, Miura S, Fukudo S, Shimokawa H
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 新規酸化ストレス増幅蛋白サイクロフィリンAによる心血管病促進機構.(JCAA最優秀賞) (2011)
  • Author(s): 佐藤公雄、福本義弘、杉村宏一郎、三浦 裕、後岡広太郎、建部俊介、山本沙織、青木竜男、下川宏明
  • Organizer: 第52回日本脈管学会総会
  • Place of Presentation: 岐阜市
• [Presentation] Cyclophylin A is a novel biomarker for oxidative stress and atherosclerosis (2011)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
  • Organizer: The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: 東京
• [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice (2011)
  • Author(s): Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H
  • Organizer: The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: 東京
• [Presentation] Plasm cyclophilin A is a novel predictor of coronary artery disease (2011)
  • Author(s): Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Takagi Y, Tsuburaya R, Ito Y, Matsumoto M, Nakayama M, Takahashi J, Shimokawa H
  • Organizer: The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: 東京
• [Presentation] Cyclophilin A is a novel biomarker for aortic aneurysms and atherosclerotic plaque instability. (2011)
  • Author(s): Satoh K
  • Organizer: 日本循環器学会シンポジウム(招待講演)
  • Place of Presentation: 横浜
• [Presentation] 新規酸化ストレス増幅蛋白サイクロフィリンAによる心血管病促進機構 (2011)
  • Author(s): 佐藤公雄
  • Organizer: 第52回日本脈管学会総会(招待講演)
  • Place of Presentation: 岐阜
• [Presentation] Cyclophilin A Plays an Important Role in the Pathogenesis of Pulmonary Arterial Hypertension in Humans - Involvement of Rho-kinase Pathway - (2011)
  • Author(s): Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Hiroaki Shimokawa et al.
  • Organizer: American Heart Association, Scientific Sessions 2011
  • Place of Presentation: Orlando,America
• [Presentation] Cyclophilin A Is a Novel Biomarker for Oxidative Stress and Atherosclerosis (2011)
  • Author(s): Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Yutaka Miura, Shunsuke Tatebe, Saori Yamamoto, Toru Shimizu, Hiroaki Shimokawa
  • Organizer: 第28回国際心臓研究学会（ISHR）日本部会
  • Place of Presentation: 東京
• [Presentation] 新規酸化ストレスバイオマーカー・サイクロフィリンAによる心血管病促進機構 (2011)
  • Author(s): 佐藤公雄、福本義弘、杉村宏一郎、三浦裕、後岡広太郎 建部俊介、山本沙織、青木竜男、下川宏明
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道
• [Presentation] Plasma Cyclophilin A Is a Novel Predictor of Coronary Artery Disease (2011)
  • Author(s): Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Hiroaki Shimokawa et al.
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京
• [Book] 『血管新生の医学』 エリスロポエチンの血管内皮保護作用と血管恒常性維持機構 (2013)
  • Author(s): 佐藤 公雄
  • Total Pages: 98
  • Publisher: BIO Clinica
• [Book] 『血管と酸化ストレス』 野出孝一編 Angiotensin Research (2011)
  • Author(s): 佐藤公雄
  • Total Pages: 5
  • Publisher: 先端医学社
• [Book] 『血圧』 血管内皮機能検査 12月号 (2011)
  • Author(s): 佐藤公雄, 下川宏明.
  • Publisher: 先端医学社
• [Remarks] 東北大学循環器内科
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.cardio.med.tohoku.ac.jp/
• [Patent(Industrial Property Rights)] サイクロフィリンＡによる心血管疾患の検査方法 (2012)
  • Inventor(s): 下川宏明、佐藤 公雄 (国立大学 法人東北大学)
  • Industrial Property Rights Holder: 下川宏明、佐藤 公雄 (国立大学 法人東北大学)
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-239615
  • Filing Date: 2012-10-30