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New biomarker discovery for patients with pulmonary hypertension

Research Project

Project/Area Number 23659408
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionTohoku University

Principal Investigator

SATOH Kimio  東北大学, 高等教育開発推進センター, 准教授 (80436120)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺高血圧 / 低酸素 / 酸化ストレス / バイオマーカー / 低酸素環境 / 炎症 / 血管平滑筋細胞 / 臨床応用 / サイクロフィリンA / Rho-kinase
Research Abstract

Pulmonary hypertension (PH) is associated with hypoxic exposure, enhanced production of reactive oxygen species (ROS) and proliferation of vascular smooth muscle cells (VSMC). In this study, we tested our hypothesis that cyclophilin A (CyPA) contributes to pulmonary vascular remodeling in patients with PH. Plasma CyPA levels were significantly elevated in patients with PH than in those without PH or healthy controls. Moreover, plasma CyPA levels increased according to the quartiles of pulmonary vascular resistance. Medical treatments reduced plasma CyPA levels in patients with PH. Finally, event-free curve revealed that high plasma CyPA predicted poor outcome (death or lungtransplantation). These results indicate that plasma CyPA is a novel biomarker for patients with PH.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (97 results)

All 2013 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (66 results) (of which Invited: 6 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Plasma cyclophilin A is a novel biomarker for coronary artery disease2013

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, MiuraY, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S, Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
    • Journal Title

      Circ J

      Volume: 77 Pages: 447-455

    • NAID

      10031138924

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma Cyclophilin A Is a Novel Biomarker for Coronary Artery Disease2013

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S,Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 2 Pages: 447-455

    • DOI

      10.1253/circj.CJ-12-0805

    • NAID

      10031138924

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl Peptidase-4 Inhibitors2013

    • Author(s)
      佐藤公雄 (Kimio Satoh)
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 5 Pages: 1156-1157

    • DOI

      10.1253/circj.CJ-13-0064

    • NAID

      10031151374

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical Coherence Tomography Is Superior to Intravascular Ultrasound for Diagnosis of Distal-Type Chronic Thromboembolic Pulmonary Hypertension2013

    • Author(s)
      Tatebe S
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 4 Pages: 1081-1083

    • DOI

      10.1253/circj.CJ-12-1493

    • NAID

      130003361592

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension2012

    • Author(s)
      Sugimura K, Fukumoto Y, Satoh K, Nochioka K, Miura Y, Aoki T, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H
    • Journal Title

      Circ J

      Volume: 76 Pages: 485-488

    • NAID

      10030036102

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of reactivepost-capillary pulmonary hypertension inpatients with left heart disease2012

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Miyamichi-Yamamoto S, Aoki T, Miura Y, Nochioka K, Satoh K, Shimokawa H
    • Journal Title

      Circ J

      Volume: 76 Pages: 1235-1244

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular target2012

    • Author(s)
      Satoh K, Fukumoto Y, Nakano M, Kagaya Y, Shimokawa H
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 58 Pages: 570-574

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current perspectives on protective rolls of erythropoietin in cardiovascular system - Erythropoietin receptor as a novel therapeutic target -2012

    • Author(s)
      Kagaya Y, Asaumi Y, Wang W, Takeda M, Nakano M, Satoh K, Fukumoto Y, Shimokawa H
    • Journal Title

      Tohoku J Exp Med

      Volume: 227 Pages: 83-91

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current Perspectives on Protective Roles of Erythropoietin in Cardiovascular System: Erythropoietin Receptor as a Novel Therapeutic Target2012

    • Author(s)
      Kagaya Y, Asaumi Y, Wang W, Takeda M, Nakano M, Satoh K, Fukumoto Y, Shimokawa H.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 227 Issue: 2 Pages: 83-91

    • DOI

      10.1620/tjem.227.83

    • NAID

      10030779568

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of Reactive Post-Capillary Pulmonary Hypertension in Patients With Left Heart Disease2012

    • Author(s)
      Tatebe S
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 5 Pages: 1235-1244

    • DOI

      10.1253/circj.CJ-11-1288

    • NAID

      10030132858

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension2012

    • Author(s)
      Sugimura K
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 2 Pages: 485-488

    • DOI

      10.1253/circj.CJ-11-1217

    • NAID

      10030036102

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular target (Review).2012

    • Author(s)
      Kimio Satoh
    • Journal Title

      J Cardiovasc Pharmacol.

      Volume: 58 Issue: 6 Pages: 570-574

    • DOI

      10.1097/fjc.0b013e318235e7bb

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of myocardial interstitial fibrosis innon-ischemic heart failure -2011

    • Author(s)
      Aoki T, Fukumoto Y, Sugimura K, Oikawa M, Satoh K, Nakano M, Nakayama M, Shimokawa H
    • Journal Title

      Comparisonbetween preserved and reduced ejectionfraction heart failure- Circ J

      Volume: 75 Pages: 2605-2613

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intensive immunospuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connectivetissue disease2011

    • Author(s)
      Miyamichi-Yamamoto S, Fukumoto Y, Sugimura K, Ishii T, Satoh K, Miura U, Tatebe S, Nochioka K, Aoki T, Do.e Zhulanqiqige, Shimokawa H
    • Journal Title

      Circ J

      Volume: 75 Pages: 2668-2674

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indispensable roles ofOX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis ofspontaneous pulmonary hypertension2011

    • Author(s)
      Rabieyousefi M, Soroosh P, Satoh K, Date1F, Ishii N, Yamashita M, Oka M, McMurtryIF, Shimokawa H, Nose M, Sugamura K,Ono M
    • Journal Title

      BMC Immunology

      Volume: 12 Pages: 67-79

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular-derived reactive oxygen species for homeostasis and diseases2011

    • Author(s)
      Satoh K, Shimokawa H
    • Journal Title

      Nitric Oxide

      Volume: 25 Pages: 211-215

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase: Important new therapeutic target in cardiovascular diseases2011

    • Author(s)
      Satoh K, Fukumoto Y, Shimokawa H
    • Journal Title

      Am J Physiol

      Volume: 301

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice.2011

    • Author(s)
      Satoh K, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 31 Issue: 5 Pages: 1116-1123

    • DOI

      10.1161/atvbaha.110.214601

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice.2011

    • Author(s)
      Nigro P, Satoh K, et al.
    • Journal Title

      J Exp Med.

      Volume: 208 Issue: 1 Pages: 53-66

    • DOI

      10.1084/jem.20101174

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase:Important new therapeutic target in cardiovascular diseases2011

    • Author(s)
      Satoh K, Fukumoto Y, Shimokawa H
    • Journal Title

      Am J Physiol

      Volume: 301 Issue: 2 Pages: 287-296

    • DOI

      10.1152/ajpheart.00327.2011

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vascular-derived reactive oxygen species for homeostasis and diseases2011

    • Author(s)
      Satoh K, Shimokawa H
    • Journal Title

      Nitric Oxide

      Volume: 25 Issue: 2 Pages: 211-215

    • DOI

      10.1016/j.niox.2011.04.005

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension2011

    • Author(s)
      Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M,McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M.
    • Journal Title

      Immunol

      Volume: 12 Issue: 1 Pages: 67-67

    • DOI

      10.1186/1471-2172-12-67

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intensive Immunosuppressive Therapy Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Pulmonary Arterial Hypertension Associated With Connective Tissue Disease.2011

    • Author(s)
      Miyamichi-Yamamoto S, Fukumoto Y, Sugimura K, Ishii T, Satoh K, Miura Y, Tatebe S, Nochioka K, Aoki T, Do E Z, Shimokawa H.
    • Journal Title

      Circ J.

      Volume: 75 Pages: 2668-2674

    • NAID

      10030032490

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of Myocardial Interstitial Fibrosis in Non-Ischemic Heart Failure.2011

    • Author(s)
      Aoki T, Fukumoto Y, Sugimura K, Oikawa M, Satoh K, Nakano M, Nakayama M, Shimokawa H.
    • Journal Title

      Circ J.

      Volume: 75 Pages: 2605-2613

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optical coherence tomography is superior to intravascular ultrasound for diagnosis of distal-type chronic thromboembolic pulmonaryhypertension

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Miura M, Yamamoto S, Yaoita N, Satoh K, Shimokawa H
    • Journal Title

      Circ J

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Plasma cyclophilin A is a novel biomarker for oxidative stress and coronary artery disease2013

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Takagi Y, Tsuburaya R, Itoh Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Current status of chronic heart failure with adult congenital heart disease in Japan2013

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Yamamaoto S, Satoh K, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Recent research progress on the role of Rho-kinase pathway in the pathogenesis of pulmonary arterial hypertension -From Bench to Bedside-2013

    • Author(s)
      Fukumoto Y, Sugimura K, Shimizu T, Qiqige Z, Yamamoto S, Tatebe S, Aoki T, Nochioka K, Miura Y, Satoh K, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Spontaneous development of arrhythmogenic right ventricular cardiomyopathy in mice overexpressing dominant-negative Rho-kinase in cardiovascular system2013

    • Author(s)
      Ellawindy A, Satoh K, Tanaka S, Ikeda S, Shimizu T, Noda K, Fukumoto Y, Kobayashi K, Nakayama K, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma cyclophilin A level is a novel biomarker of vasospastic angina2013

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Takagi Y, Tsuburaya R, Itoh Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma cyclophilin A as a novel biomarker for pulmonary hypertension in humans2013

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Ito H, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension in rats2013

    • Author(s)
      Al-Mamun E, Satoh K, Tanaka S, Shimizu T, Nergui S, Fukumoto Y, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Impact of positive myocardial biopsy on ventricular function and prognosis in patients with cardiac sarcoidosis2013

    • Author(s)
      Miura Y, Fukumoto Y, Sugimura K, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Satoh K, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Enhanced Rho-kinase activity in circulating leukocytes in patients with heart failure2013

    • Author(s)
      Qiqige Z, Fukumoto Y, Sugimura K, Miura Y, Tatebe S, Yamamoto S, Aoki T, Nochioka K, Satoh K, Nergui S, Kondoh M, Nakano M, Wakayama Y, Fukuda K, Nihei T, Takahashi J, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice2013

    • Author(s)
      Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Shimokawa H
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺高血圧の重症度と予後予測のための新規バイオマーカー・サイクロフィリンA2013

    • Author(s)
      佐藤公雄、福本義弘、杉村宏一郎、三浦裕、青木竜男、後岡広太郎、建部俊介、山本沙織、清水亨、矢尾板信裕、中村一文、伊藤浩、下川宏明
    • Organizer
      第42回日本心脈管作動物質学会学術集会
    • Place of Presentation
      奈良
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma Cyclophilin A is a novel biomarker for oxidative stress and coronary artery disease.2013

    • Author(s)
      佐藤公雄 (Kimio Satoh)
    • Organizer
      日本循環器学会総会 (シンポジウム)
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Spontaneous Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Mice Over-expressing Dominant-Negative Rho-kinase in the Cardiovascular System2013

    • Author(s)
      Alia Ellawindy
    • Organizer
      日本循環器学会総会 (International Young Investigator's Award)
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Plasma Cyclophilin A Level Is a Novel Biomarker of Vasospastic Angina2013

    • Author(s)
      佐藤公雄 (Kimio Satoh)
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Plasma Cyclophilin A as a Novel Biomarker for Pulmonary Hypertension in Humans2013

    • Author(s)
      佐藤公雄 (Kimio Satoh)
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス分泌蛋白CyclophylinAによる肺高血圧促進機構-Rho-kinase系の関与-2012

    • Author(s)
      佐藤公雄、福本義弘、杉村宏一郎、三浦裕、青木竜男、後岡広太郎、建部俊介、山本沙織、清水亨、下川宏明
    • Organizer
      第1回日本肺循環学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Percutaneous transluminal pulmonary angioplasty markedly ameliorates pulmonary hemodynamics and long-term prognosis of patients with distal-type chronic thromboembolic pulmonary hypertension2012

    • Author(s)
      Fukumoto Y, Sugimura K, Satoh K, Nochioka K, Miura Y, Aoki T, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Remarkable effectiveness of percutaneous transluminal pulmonary angioplasty for hemodynamics and long-term prognosis in patients with distal-type chronic thromboembolic pulmonary hypertension2012

    • Author(s)
      Sugimura K, Fukumoto Y, Satoh K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Munich, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma cyclophilin A level is a novel biomarker of coronary artery disease2012

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Takagi Y, Takahashi J, Shimokawa H
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Munich, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] Rho kinase activity in circulating leukocytes as a novel bio marker of heart failure. (#12636)2012

    • Author(s)
      Doe Z, Fukumoto Y, Sugimura K, Miura Y, Tatebe S, Yamamoto, AokiT, Nohicoka K, Satoh K, SuvdN, Kondo M, Nakano M, Wakayama Y, Fukuda K, Nihei T, Kikuchi Y, Takahashi J, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Spontaneous development of arrhythmogenic right ventricular cardiomyopathy in mice overexpressing dominant-negative Rho-kinase in vascular smooth muscle cells. (#10984)2012

    • Author(s)
      Ellawindy A, Satoh K, Tanaka S, Ikeda S, Shimizu T, Noda K, Fukumoto Y, KobayashiK, NakayamaK,Shimokawa H
    • Organizer
      American Heart Association(AHA) Scientific Sessions
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Percutaneous transluminalpulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis of patients with distal-type chronic thromboembolic pulmonary hypertension. (#13752)2012

    • Author(s)
      Miura Y, Sugimura K, Fukumoto Y, Satoh K, Nohicoka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma cyclophilin A as a novel biomarker for pulmonary hypertension in humans. (#11189)2012

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura M, Nochioka K, Aoki T, TatebeS, Yamamoto S, Shimizu T, Nakamura K, Ito H, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice. (#12299)2012

    • Author(s)
      ShimizuT, Tanaka S, Satoh K, Fukumoto Y, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Prognostic significance of enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall in patients with pulmonary hypertension. (#10873)2012

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Satoh K, MiuraY, Nohicoka K, Aoki T, Yamamoto S, Oikawa-WakayamaM,KagayaY, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of percutaneous transluminal pulmonary angioplasty in patients with distal-type chromic thromboembolic pulmonary hypertension2012

    • Author(s)
      Sugimura K, Fukumoto Y, Satoh K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Rho-kinase activity in circulating leukocytes as a novel biomarker in patients with chronic heart failure2012

    • Author(s)
      Zhulan Qiqige, Fukumoto Y, Sugimura K, Miura Y, Yamamoto S, Tatebe S, Aoki T, Nochioka K, Satoh K, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice2012

    • Author(s)
      Shimizu T, Tanaka S, Satoh K, Fukumoto Y, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with distal-type chronic thromboembolic pulmonary hypertension2012

    • Author(s)
      Sugimura K, Fukumoto Y, Satoh K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Usefulness of optical coherence tomography in diagnosis of distal-type chronic thromboembolic pulmonary hypertension -comparison with intravascular ultrasound-2012

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Aoki T, Yamamoto S, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Increased incidence of heart failure in the East Japan Earthquake Disaster2012

    • Author(s)
      Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Yamamoto S, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma cyclophilin a level is a novel biomarker of coronary artery disease2012

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Osaki S, Takagi Y, Tsuburaya R, Itoh Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Itoh K, Yasuda S, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Cyclophilin A plays an important role in the pathogenesis of pulmonary arterial hypertension in humans .involvement of rho-kinase pathway-2012

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Itoh H, Shimokawa H
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 酸化ストレス分泌蛋白Cyclophylin Aによる肺高血圧促進機構-Rho-kinase系の関与-2012

    • Author(s)
      佐藤公雄、福本義弘、杉村宏一郎、三浦裕、青木竜男、後岡広太郎、建部俊介、中村一文、伊藤浩、下川宏明
    • Organizer
      第12回日本NO学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規酸化ストレスマーカーのサイクロフィリンAの冠動脈疾患診断における有用性2012

    • Author(s)
      佐藤公雄、福本義弘、杉村宏一郎、三浦裕、後岡広太郎、青木竜男、建部俊介、山本沙織、高木祐介、下川宏明
    • Organizer
      第12回日本NO学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasma Cyclophilin A as a Novel Biomarker for Pulmonary Hypertension in Humans2012

    • Author(s)
      佐藤公雄 (Kimio Satoh)
    • Organizer
      米国心臓病学会議 (AHA 2012)
    • Place of Presentation
      オーランド(米国)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Plasma Cyclophilin A is a novel biomarker for coronary artery disease.2012

    • Author(s)
      佐藤公雄 (Kimio Satoh)
    • Organizer
      欧州心臓学会議 (ESC 2012)
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Plasma Cyclophilin A Level Is a Novel Biomarker of Coronary Artery Disease2012

    • Author(s)
      Kimio Satoh, Yoshihiro Fukumoto, Hiroaki Shimokawa et al.
    • Organizer
      日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Cyclophilin A Plays an Important Role in the Pathogenesis of Pulmonary Arterial Hypertension in Humans - Involvement of Rho-kinase Pathway -2012

    • Author(s)
      Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Hiroaki Shimokawa et al.
    • Organizer
      日本循環器学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規酸化ストレスマーカー・サイクロフィリンAによる心血管病促進機構2011

    • Author(s)
      佐藤公雄、福本義弘、杉村宏一郎、三浦裕、後岡広太郎、青木竜男、建部俊介、山本沙織、下川宏明
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      北海道ルフツ
    • Year and Date
      2011-07-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Intensive immunosuppressive therapy improves pulmonary hemodynamics and prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease2011

    • Author(s)
      Yamamoto S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Tatebe S, Nakano M, Oikawa M, Ishii T, Shimokawa H
    • Organizer
      European Society of Cardiology 2011
    • Place of Presentation
      Paris
    • Related Report
      2012 Final Research Report
  • [Presentation] Marked effectiveness of percutaneous transluminal pulmonary angioplasty in patients with distal-type chronic thromboembolic pulmonary hypertension2011

    • Author(s)
      Sugimura K, Fukumoto Y, Satoh K, Miura Y, Tatebe S, Yamamoto S, Shimokawa H
    • Organizer
      European Society of Cardiology 2011
    • Place of Presentation
      Paris
    • Related Report
      2012 Final Research Report
  • [Presentation] Optical coherence tomography is superior to intravenous ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension2011

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Yamamoto S, Shimokawa H
    • Organizer
      European Society of Cardiology 2011
    • Place of Presentation
      Paris
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical characteristics and prognosis of patients with post-capillary reactive pulmonary hypertension caused by left heart disease2011

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Yamamoto S, Shimokawa H
    • Organizer
      European Society of Cardiology 2011
    • Place of Presentation
      Paris
    • Related Report
      2012 Final Research Report
  • [Presentation] Prognostic impact of myocardial fibrosis in patients with heart failure -Comparison between preserved and reduced ejection fraction heart failure- (#12377)2011

    • Author(s)
      Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Nakayama M, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics in patients with distal-type chronic thromboembolic pulmonary hypertension. (#11867)2011

    • Author(s)
      Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Cyclophilin A plays an important role in the pathogenesis of pulmonary arterial hypertension in humans -Involvement of Rho-kinase Pathway- (#10569)2011

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice. (#9348)2011

    • Author(s)
      Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Cyclophilin A is a novel biomarker for aortic aneurysms and atherosclerotic plaque instability2011

    • Author(s)
      Satoh K, Fukumoto Y, Shimizu T, Suzuki H, Sugimura K, Miura Y, Tatebe S, Miyamichi S, Berk BC, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] New therapeutic strategies for pulmonary hypertension: Rho-kinase inhibitor and balloon pulmonary angioplasty2011

    • Author(s)
      Sugimura K, Fukumoto Y, Satoh K, Miura Y, Tatebe S, Miyamichi S, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of intensive immunosuppressive therapy on pulmonary hemodynamics in patients with pulmonary arterial hypertension associated with connective tissue disease2011

    • Author(s)
      Miyamichi S, Fukumoto Y, Sugimura K, Satoh K, Nakano M, Miura Y, Tatebe S, Oikawa M, Ishii T, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Optical coherence tomography as a novel diagnostic tool for distal-type chronic thromboembolic pulmonary hypertension2011

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Nakano M, Miura Y, Miyamichi S, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Post-capillary reactive pulmonary hypertension is an adverse prognostic factor in patients with left heart disease2011

    • Author(s)
      Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Miyamichi S, Oikawa M, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice2011

    • Author(s)
      Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Gender difference in prognostic impact of myocardial fibrosis in heart failure patients -Usefulness of myocardial biopsy-2011

    • Author(s)
      Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Tatebe S, Miyamichi S, Nakayama M, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Different brain processing from the right and the left ventricles in humans2011

    • Author(s)
      Suzuki H, Satoh K, Miura S, Fukudo S, Shimokawa H
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規酸化ストレス増幅蛋白サイクロフィリンAによる心血管病促進機構.(JCAA最優秀賞)2011

    • Author(s)
      佐藤公雄、福本義弘、杉村宏一郎、三浦 裕、後岡広太郎、建部俊介、山本沙織、青木竜男、下川宏明
    • Organizer
      第52回日本脈管学会総会
    • Place of Presentation
      岐阜市
    • Related Report
      2012 Final Research Report
  • [Presentation] Cyclophylin A is a novel biomarker for oxidative stress and atherosclerosis2011

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H
    • Organizer
      The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice2011

    • Author(s)
      Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H
    • Organizer
      The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Plasm cyclophilin A is a novel predictor of coronary artery disease2011

    • Author(s)
      Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Takagi Y, Tsuburaya R, Ito Y, Matsumoto M, Nakayama M, Takahashi J, Shimokawa H
    • Organizer
      The 28^<th> Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Cyclophilin A is a novel biomarker for aortic aneurysms and atherosclerotic plaque instability.2011

    • Author(s)
      Satoh K
    • Organizer
      日本循環器学会シンポジウム(招待講演)
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規酸化ストレス増幅蛋白サイクロフィリンAによる心血管病促進機構2011

    • Author(s)
      佐藤公雄
    • Organizer
      第52回日本脈管学会総会(招待講演)
    • Place of Presentation
      岐阜
    • Related Report
      2011 Research-status Report
  • [Presentation] Cyclophilin A Plays an Important Role in the Pathogenesis of Pulmonary Arterial Hypertension in Humans - Involvement of Rho-kinase Pathway -2011

    • Author(s)
      Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Hiroaki Shimokawa et al.
    • Organizer
      American Heart Association, Scientific Sessions 2011
    • Place of Presentation
      Orlando,America
    • Related Report
      2011 Research-status Report
  • [Presentation] Cyclophilin A Is a Novel Biomarker for Oxidative Stress and Atherosclerosis2011

    • Author(s)
      Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Yutaka Miura, Shunsuke Tatebe, Saori Yamamoto, Toru Shimizu, Hiroaki Shimokawa
    • Organizer
      第28回国際心臓研究学会(ISHR)日本部会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規酸化ストレスバイオマーカー・サイクロフィリンAによる心血管病促進機構2011

    • Author(s)
      佐藤公雄、福本義弘、杉村宏一郎、三浦裕、後岡広太郎 建部俊介、山本沙織、青木竜男、下川宏明
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      北海道
    • Related Report
      2011 Research-status Report
  • [Presentation] Plasma Cyclophilin A Is a Novel Predictor of Coronary Artery Disease2011

    • Author(s)
      Kimio Satoh, Yoshihiro Fukumoto, Koichiro Sugimura, Hiroaki Shimokawa et al.
    • Organizer
      第19回日本血管生物医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] 『血管新生の医学』 エリスロポエチンの血管内皮保護作用と血管恒常性維持機構2013

    • Author(s)
      佐藤 公雄
    • Total Pages
      98
    • Publisher
      BIO Clinica
    • Related Report
      2012 Annual Research Report
  • [Book] 『血管と酸化ストレス』 野出孝一編 Angiotensin Research2011

    • Author(s)
      佐藤公雄
    • Total Pages
      5
    • Publisher
      先端医学社
    • Related Report
      2011 Research-status Report
  • [Book] 『血圧』 血管内皮機能検査 12月号2011

    • Author(s)
      佐藤公雄, 下川宏明.
    • Publisher
      先端医学社
    • Related Report
      2011 Research-status Report
  • [Remarks] 東北大学循環器内科

    • URL

      http://www.cardio.med.tohoku.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.cardio.med.tohoku.ac.jp/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] サイクロフィリンAによる心血管疾患の検査方法2012

    • Inventor(s)
      下川宏明、佐藤 公雄 (国立大学 法人東北大学)
    • Industrial Property Rights Holder
      下川宏明、佐藤 公雄 (国立大学 法人東北大学)
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-239615
    • Filing Date
      2012-10-30
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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