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Analysis of the pathophysiology of HGPS

Research Project

Project/Area Number 23659411
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionNiigata University (2012)
Chiba University (2011)

Principal Investigator

MINAMINO Tohru  新潟大学, 医歯学系, 教授 (90328063)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords早老症 / p53 / 動脈硬化 / 老化 / 早老症候群
Research Abstract

The present study has clarified that the DNA damage signal pathway plays a crucialrole in the onset of atherosclerosis in HGPS.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (64 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (40 results) (of which Invited: 12 results) Book (15 results) Remarks (2 results)

  • [Journal Article] Adipose tissue inflammation in diabetes and heart failure.2013

    • Author(s)
      Shimizu I, Yoshida Y, Katsuno T,Minamino T.
    • Journal Title

      Microbes and Infection

      Volume: 15 Issue: 1 Pages: 11-17

    • DOI

      10.1016/j.micinf.2012.10.012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-medeiated pathway2012

    • Author(s)
      Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32(8) Issue: 8 Pages: 1902-9

    • DOI

      10.1161/atvbaha.112.248930

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012

    • Author(s)
      Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
    • Journal Title

      Cell

      Volume: 149 Issue: 6 Pages: 1298-1313

    • DOI

      10.1016/j.cell.2012.03.047

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012

    • Author(s)
      Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I
    • Journal Title

      Hypertension

      Volume: 59 Issue: 3 Pages: 627-633

    • DOI

      10.1161/hypertensionaha.111.175208

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aldosterone Does Not Contribute to Renal p21 Expression During the Development of Angiotensin II-Induced Hypertension in Mice2012

    • Author(s)
      Nakano D, Minamino T, et al
    • Journal Title

      Am J Hypertens

      Volume: 25 Issue: 3 Pages: 354-358

    • DOI

      10.1038/ajh.2011.224

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging2011

    • Author(s)
      Odaka K, Minamino T, et al
    • Journal Title

      PLos One

      Volume: 6 Issue: 10 Pages: e25487-e25487

    • DOI

      10.1371/journal.pone.0025487

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of JAGGED1 in arterial lesions after vascular injury2011

    • Author(s)
      Wu X, Minamino T, et al
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 31 Issue: 9 Pages: 2000-2006

    • DOI

      10.1161/atvbaha.111.225144

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 次世代の血管新生治療の開発2013

    • Author(s)
      Minamino T.
    • Organizer
      第12回日本再生医療学会総会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Cellular aging signalnetwork and lifestyle-relateddisease2013

    • Author(s)
      Minamino T.
    • Organizer
      第77回日本循環器学会・学術集会ミートザエキスパートセッション
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiac-adipose vicious cycle is critically involved in the development of heart failure2013

    • Author(s)
      Minamino T.
    • Organizer
      第77回日本循環器学会・学術集会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiac-adipose vicious cycle is critically involved in the development of heart failure2013

    • Author(s)
      Minamino T
    • Organizer
      日本循環器学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Cellular aging signal network and lifestyle-related disease2013

    • Author(s)
      Minamino T
    • Organizer
      日本循環器学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 老化、細胞死と循環代謝性疾患2012

    • Author(s)
      Minamino T.
    • Organizer
      第21回日本Cell Death学会シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2012-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化シグナルネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T.
    • Organizer
      第35回日本分子生物学会シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 高血圧と血管老化のメカニズム2012

    • Author(s)
      Minamino T.
    • Organizer
      第20回日本血管生物医学会シンポジウム
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] 臓器間老化シグナル制御と生活習慣病2012

    • Author(s)
      Minamino T.
    • Organizer
      第16回日本心血管内分泌代謝学会シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Aging and cardiovascular disease2012

    • Author(s)
      Minamino T.
    • Organizer
      2012 Scientific Session. American Heart Association International Forum
    • Place of Presentation
      Los Angels, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化シグナルネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T.
    • Organizer
      第33回日本肥満学会シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of Cardiovascular Metabolism by the Aging Signal Network2012

    • Author(s)
      Minamino T.
    • Organizer
      第35回日本高血圧学会シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 脂肪老化制御と生活習慣病2012

    • Author(s)
      Minamino T.
    • Organizer
      第12回日本抗加齢医学会総会研究助成記念講演
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Akt1 による寿命調節機構2012

    • Author(s)
      Minamino T.
    • Organizer
      第12回日本抗加齢医学会総会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代の血管新生治療の開発2012

    • Author(s)
      Minamino T.
    • Organizer
      第60回日本輸血・細胞治療学会総会シンポジウム
    • Place of Presentation
      郡山
    • Related Report
      2012 Final Research Report
  • [Presentation] 臓器間ネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T.
    • Organizer
      第85回日本内分泌学会総会シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Lifespan regulatory system as a potential therapeutic target for cardiovascular disease2012

    • Author(s)
      Minamino T.
    • Organizer
      第76回日本循環器学会・学術集会Topics
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Lifespan regulatory system and cardiovascular disease2012

    • Author(s)
      Minamino T.
    • Organizer
      第76回日本循環器学会・学術集会Topics
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Cardiovascular agingand circadian clock2012

    • Author(s)
      Minamino T.
    • Organizer
      第76回日本循環器学会・学術集会 シンポジウム
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Aging and cardiovascular disease.2012

    • Author(s)
      Minamino T
    • Organizer
      American Heart Association
    • Place of Presentation
      Los Angeles Convention Ctr(USA)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 臓器間ネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T
    • Organizer
      日本内分泌学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Akt1による寿命調節機構2012

    • Author(s)
      Minamino T
    • Organizer
      日本抗加齢医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脂肪老化制御と生活習慣病2012

    • Author(s)
      Minamino T
    • Organizer
      日本抗加齢医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Regulation of Cardiovascular Metabolism by the Aging Signal Network.2012

    • Author(s)
      Minamino T
    • Organizer
      日本高血圧学会
    • Place of Presentation
      ウェスティンナゴヤキャッスル・名古屋能楽堂(名古屋市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 老化シグナルネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T
    • Organizer
      日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 臓器間老化シグナル制御と生活習慣病2012

    • Author(s)
      Minamino T
    • Organizer
      日本心血管内分泌代謝学会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 高血圧と血管老化のメカニズム2012

    • Author(s)
      Minamino T
    • Organizer
      日本血管生物医学会
    • Place of Presentation
      あわぎんホール(徳島市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 老化シグナルネットワークによる循環代謝制御2012

    • Author(s)
      Minamino T
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Novel strategy fortherapeutic angiogenesis2011

    • Author(s)
      Minamino T.
    • Organizer
      第17回日本遺伝子治療学会 シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of adipose senescence in lifestyle-related disease2011

    • Author(s)
      Minamino T.
    • Organizer
      第43回日本動脈硬化学会総会・学術集会シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Lifestyle-related disease and cellular aging signal network2011

    • Author(s)
      Minamino T.
    • Organizer
      第63回日本細胞生物学会シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化からみた生活習慣病2011

    • Author(s)
      Minamino T.
    • Organizer
      第15回日本適応医学会シンポジウム
    • Place of Presentation
      浜松
    • Year and Date
      2011-06-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 老化からみた生活習慣病2011

    • Author(s)
      Minamino T.
    • Organizer
      第14回日本抗加齢医学総会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-05-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞老化シグナルと生活習慣病2011

    • Author(s)
      Minamino T.
    • Organizer
      第100回日本病理学会ワークショップ
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞老化シグナルによる寿命制御と加齢関連疾患2011

    • Author(s)
      Minamino T.
    • Organizer
      第84回日本内分泌学会教育講演
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 末梢血単核球を用いた血管新生治療の効果と分子機序2011

    • Author(s)
      Minamino T.
    • Organizer
      第59回日本日本輸血・細胞治療学会総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-04-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代血管新生治療開発の展望2011

    • Author(s)
      Minamino T.
    • Organizer
      第52回日本脈管学会シンポジウム
    • Place of Presentation
      岐阜
    • Related Report
      2012 Final Research Report
  • [Presentation] 寿命制御と細胞老化シグナル、加齢関連疾患の発症メカニズム2011

    • Author(s)
      Minamino T.
    • Organizer
      第33回日本基礎老化学会シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞老化シグナルによる寿命制御と加齢関連疾患2011

    • Author(s)
      南野 徹
    • Organizer
      第84回日本内分泌学会 教育講演(招待講演)
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 老化、細胞死と循環代謝性疾患

    • Author(s)
      Minamino T
    • Organizer
      日本Cell Death学会
    • Place of Presentation
      名古屋大学(名古屋市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 第II循環器疾患と慢性炎症2013

    • Author(s)
      岡田将、南野徹
    • Publisher
      南山堂
    • Related Report
      2012 Final Research Report
  • [Book] III各種疾患と時間治療2013

    • Author(s)
      南野徹
    • Publisher
      医薬ジャーナル社大阪
    • Related Report
      2012 Final Research Report
  • [Book] I.糖尿病,A.基礎分野での進歩2013

    • Author(s)
      清水逸平,南野徹
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 第1章高齢者の身体的特徴の変化2012

    • Author(s)
      南野 徹
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] 第2章病態2012

    • Author(s)
      南野徹
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] 第4章炎症・血栓・老化関連2012

    • Author(s)
      勝野太郎、南野徹
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] 高齢者用食品の開発と展望2012

    • Author(s)
      南野 徹
    • Total Pages
      302
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Annual Research Report
  • [Book] 循環器医から寄せられる「糖尿病と血管合併症」に関する100の質問2012

    • Author(s)
      南野 徹
    • Total Pages
      231
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] 循環器疾患の最新医療2012

    • Author(s)
      舘野馨、南野 徹
    • Total Pages
      506
    • Publisher
      先端医療技術研究所
    • Related Report
      2012 Annual Research Report
  • [Book] フォークヘッド転写因子2011

    • Author(s)
      森谷純治、南野徹
    • Publisher
      朝倉書店
    • Related Report
      2012 Final Research Report
  • [Book] V. 末梢血管の疾患の手術適応と至適時期2011

    • Author(s)
      舘野馨,南野徹
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] Chapter4血管・心筋再生療法の臨床2011

    • Author(s)
      舘野馨,森谷純治,南野徹
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Final Research Report
  • [Book] I.糖尿病,A.基礎分野での進歩2011

    • Author(s)
      横山真隆,南野徹
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] II.疾患の病因と病態2011

    • Author(s)
      森谷純治,南野徹
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] Annual Review糖尿病・代謝・内分泌20112011

    • Author(s)
      横山真隆,南野 徹
    • Publisher
      中外医学社
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.med.niigata-u.ac.jp/car/

    • Related Report
      2012 Final Research Report
  • [Remarks] 新潟大学大学院医歯学研究院循環器内科

    • URL

      http://www.med.niigata-u.ac.jp/car/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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