Analysis of the pathophysiology of HGPS
| Project/Area Number |
23659411
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Niigata University (2012)
Chiba University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 早老症 / p53 / 動脈硬化 / 老化 / 早老症候群 |
|---|
| Research Abstract |
The present study has clarified that the DNA damage signal pathway plays a crucialrole in the onset of atherosclerosis in HGPS.
|
Report
(3 results)
Research Products
(64 results)
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[Journal Article] Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-medeiated pathway2012
Author(s)
Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32(8)
Issue: 8
Pages: 1902-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
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Journal Title
Cell
Volume: 149
Issue: 6
Pages: 1298-1313
DOI
Related Report
Peer Reviewed
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[Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012
Author(s)
Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I
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Journal Title
Hypertension
Volume: 59
Issue: 3
Pages: 627-633
DOI
Related Report
Peer Reviewed
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