Elucidation of molecular mechanisms of lymphedema

• Project/Area Number: 23659412
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: MANABE Ichiro 東京大学, 医学部・附属病院, 特任准教授 (70359628)
• Co-Investigator(Renkei-kenkyūsha): FUJIU Katsuhito 東京大学, 医学部・附属病院, 特任助教 (30422306) ; EGUCHI Kosei 東京大学, 医学部・附属病院, 特任助教 (20529094) ; MATSUMOTO Sahohime 東京大学, 医学部・附属病院, 特任助教 (80570184)
• Project Period (FY): 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: リンパ浮腫 / 慢性炎症 / リンパ管

Research Abstract

In this project we addressed the mechanisms underlying the development of lymphedema. We found that an excessive generation(lymphangiogenesis) of immature lymphatic vessels pivotally contributes to the development of lymphedema in a mouse lymphedema model. Moreover, we found that inflammatory processes promote lymphangiogenesis. Furthermore, we identified chemical compounds that suppress lymphedema by inhibiting the inflammatory processes.

Research Products

• [Journal Article] Saturated fatty acid and TLR signaling linkβcell dysfunction and islet inflammation (2012)
  • Author(s): Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R
  • Journal Title: Cell Metab Volume: 15 Pages: 518-533
• [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling (2012)
  • Author(s): Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R
  • Journal Title: Blood
• [Presentation] 心・腎・代謝疾患における実質・間質細胞コミュニケーションシンポジウム14 :多臓器間ネットワーク異常に基づく循環器系機能障害と薬物治療 (2012)
  • Author(s): 真鍋一郎
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-15
• [Presentation] 心腎代謝における慢性炎症とエイジング (2012)
  • Author(s): 真鍋一郎
  • Organizer: 第28回臨床フリーラジカル会議
  • Place of Presentation: 京都
  • Year and Date: 2012-01-20
• [Presentation] Propagation of chronic inflammation underlies multiple tissue dysfunctions in lifestyle diseases Symposium 2S15pI : Chronic inflammation and epigenetics in life-style disease (2011)
  • Author(s): Manabe I
  • Organizer: 第34回日本分子生物学会年会(シンポジウムオーガナイザー)
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] Chronic inflammatory processes mediated by parenchymal sensor cells and stromal effector cells Symposium 3 : Obesity and Adipose Tissue Inflammation (2011)
  • Author(s): 真鍋一郎
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-09
• [Presentation] 心血管代謝疾患における慢性炎症シンポジウム3 :慢性炎症と心不全 (2011)
  • Author(s): 真鍋一郎
  • Organizer: 第15回日本心不全学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-10-13
• [Presentation] 慢性炎症と心血管・代謝・腎疾患シンポジウムBS3組織炎症と肥満・生活習慣病 (2011)
  • Author(s): 真鍋一郎
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-26
• [Presentation] 慢性炎症と膵β細胞機能障害シンポジウム21慢性炎症と糖代謝異常 (2011)
  • Author(s): 真鍋一郎
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-21
• [Presentation] Chronic inflammation in homeostasis and pathology in cardiometabolic syndrome and chronic kidney disease Symposium 2 :循環器疾患の成因における慢性炎症の意義 (2011)
  • Author(s): 真鍋一郎
  • Organizer: 第76回日本循環期学会総会・学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2011-03-16
• [Remarks]
  • URL: http://plaza.umin.ac.jp/manabe