Generation of a novel research area "sex difference in cardiovascular system based on XY chromosomes"
| Project/Area Number |
23659413
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子心臓病態学 / 心臓 / 性差 / 循環器 / 性染色体 |
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| Research Abstract |
There is gender difference in susceptibility to certain diseases and responses to drugs. This is partly attributed to the different gonad determined by SRY gene on the Y-chromosome, and resultant different sex hormones between male and female. However, the difference in the XY chromosome also contributes to the gender difference. The Y-chromosome containing about 80 genes is present only in male. In contrast, in female (YY) 10% of genes (about 100 genes) on the X-chromosome do not execute inactivation and thereby female has copy number for these 100 genes twice as many as male. However, the gender difference caused by the XY chromosome is poorly understood mainly because of technical deficit. In this project, we established XX♀、XX♂、XY♀、XY♂ mice by cross-hybridizing XY- SRY mice with wildtype XX female mice, and we collected the baseline data for cardiovascular functions.
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Report
(3 results)
Research Products
(73 results)
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[Journal Article] Circulating KCNH2 current-activating factor in patients with heart failure and ventricular tachyarrhythmia2011
Author(s)
Siguyama H, Nakamura K, Morita H, Akagi S, Tani Y, Katayama Y, Nishii N, Miyoshi T, Nagase S, Kohno K, Kusano FK, Ohe T, Kurokawa J, Furukawa T, Ito H.
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Peer Reviewed
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[Presentation] Polymorphisms on atrial fibrillation - associated locus 4q25 could accelerate the disease onset and the recurrence after pulmonary vein isolation2012
Author(s)
Ebana Y, Hachiya H, Inaba O, Nitta J, Swawabe M, Nogami A, Takahashi A, Nakamura H, Hirao K, Isobe M, Furukawa T
Organizer
The 76th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
福岡
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[Presentation] Genetic risks of atrial fibrillation in Japan2011
Author(s)
Furukawa T
Organizer
4th Asia Pacific Heart Rhythm Society Scientific Session, 26th Annual Scientific Session of Japanese Heart Rhythm Society, 28th Annual Scientific Session of Japanese Society of Electrophysiology(招待講演)
Place of Presentation
福岡
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