| Project/Area Number |
23659416
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SANADA Shoji 大阪大学, 保健センター, 講師 (70593797)
MATSUZAKI Takashi 大阪大学, 医学系研究科, 特任助教 (90456939)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 分子心臓病態学 / 劇症型心筋症 / ドラッグデリバリー / 劇症型心筋炎 / 診断 / 治療 / リポソーム |
|---|
| Research Abstract |
The prognosis of fluminant myocarditis due to autoimmune myocarditis is poor. Thus, the development of new treatment for fluminant myocarditis is medical unmet need. We found that nano-size particles were accumulated in myocarditis hearts. Then, we have developed FK506(an immunosuppressant drug) coated with nano-size liposome. In rat myocarditis model, we found that liposomal FK506 prevented the cardiac dysfunction more than FK506 did. Liposomes are promising for developing new treatments for fluminant myocarditis.
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