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What is the physiological role of cardiac stem cells ?

Research Project

Project/Area Number 23659417
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokyo (2013)
Osaka University (2011-2012)

Principal Investigator

NAITO Atsuhiko  東京大学, 医学部附属病院, 助教 (10588891)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords分子心臓病態学 / 心臓幹細胞 / c-kit / 心筋細胞 / 幹細胞
Research Abstract

Accumulating evidence suggests the presence of so called 'cardiac stem cells'. However, physiological role of cardiac stem cells are not known yet. In this study, we tried to establish a mouse model that can induce Cre/LoxP recombination only in cardiac stem cells which express both c-kit and alpha MHC (aMHC). We have successfully established a transgenic mice which express Cre gene with nuclear localization sequence under the control of inducible aMHC promoter. By crossing with another transgenic mice which express tTA (tetracycline transactivator) or rtTA (reverse tTA), we can induce Cre/LoxP recombination exclusively in a specific type of cardiomyocytes, such as pacemaker cells, ventricular cells, and cardiac stem cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (35 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (19 results) (of which Invited: 3 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure2014

    • Author(s)
      Oka T
    • Journal Title

      Circ Res

      Volume: 114 Issue: 3 Pages: 565-571

    • DOI

      10.1161/circresaha.114.300507

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wnt シグナルと心臓の生老病死2014

    • Author(s)
      内藤篤彦
    • Journal Title

      心臓

      Volume: 46 Pages: 290-295

    • Related Report
      2013 Final Research Report
  • [Journal Article] Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells2013

    • Author(s)
      Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I
    • Journal Title

      Hypertens Res

      Volume: 36(10) Issue: 10 Pages: 859-65

    • DOI

      10.1038/hr.2013.52

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 補体分子C1q と心血管疾患2013

    • Author(s)
      内藤篤彦
    • Journal Title

      血管医学

      Volume: 14

    • Related Report
      2013 Final Research Report
  • [Journal Article] Chronic inflammation and organismal aging2013

    • Author(s)
      Naito AT, Komuro I
    • Journal Title

      Clin Calcium

      Volume: 23(1)(Doi:CliCa13015158) Pages: 51-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Aging and Bio-Motor function. Chronic inflammation and organismal aging.2013

    • Author(s)
      Naito AT
    • Journal Title

      Clin Calcium.

      Volume: 23 Pages: 51-58

    • Related Report
      2012 Research-status Report
  • [Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012

    • Author(s)
      Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
    • Journal Title

      Cell

      Volume: 149 Issue: 6 Pages: 1298-1313

    • DOI

      10.1016/j.cell.2012.03.047

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012

    • Author(s)
      Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I
    • Journal Title

      Hypertension

      Volume: 59 Issue: 3 Pages: 627-633

    • DOI

      10.1161/hypertensionaha.111.175208

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model2011

    • Author(s)
      Hayashi K, Hashimoto M, Koda M, Naito AT, Murata A, Okawa A, Takahashi K, Yamazaki M
    • Journal Title

      J Neurosurg Spine

      Volume: 15(6) Issue: 6 Pages: 582-93

    • DOI

      10.3171/2011.7.spine10775

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Wnt シグナルによる心臓・大血管発生の制御2011

    • Author(s)
      内藤篤彦
    • Journal Title

      心臓

      Volume: 43 Pages: 594-598

    • NAID

      130002146601

    • Related Report
      2013 Final Research Report
  • [Journal Article] 小室一成ヒト循環器疾患モデルとしてのiPS細胞の利用2011

    • Author(s)
      内藤篤彦、住田智一
    • Journal Title

      再生医療

      Volume: 10 Pages: 204-204

    • Related Report
      2013 Final Research Report
  • [Presentation] 心臓の生老病死におけるWnt シグナルの役割2013

    • Author(s)
      内藤篤彦
    • Organizer
      北海道カルディアックセミナー
    • Place of Presentation
      札幌市
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Wnt シグナルと老化関連疾患2013

    • Author(s)
      内藤篤彦
    • Organizer
      日本心血管内分泌代謝学会
    • Place of Presentation
      吹田市
    • Related Report
      2013 Final Research Report
  • [Presentation] Wnt signaling in the Heart ~From the Cradle to the Grave~2013

    • Author(s)
      Atsuhiko Naito
    • Organizer
      河口湖カンファレンス
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Wnt signaling in the Heart ~From the Cradle to the Grave~2013

    • Author(s)
      内藤篤彦
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸市
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of Endothelial Wnt signaling on Cardiac function2013

    • Author(s)
      Atsuhiko Naito
    • Organizer
      International Society for Heart Research
    • Place of Presentation
      San Diego, CA
    • Related Report
      2013 Final Research Report
  • [Presentation] The Interaction of FoxO with b-catnin Contributes to Skeletal Muscle Myopathy2013

    • Author(s)
      Katsuki Okada, Atsuhiko Naito, Issei Komuro
    • Organizer
      International Society for Heart Research
    • Place of Presentation
      San Diego, CA
    • Related Report
      2013 Final Research Report
  • [Presentation] Wnt シグナルと老化関連疾患2013

    • Author(s)
      内藤篤彦
    • Organizer
      脳心血管抗加齢研究会2013
    • Place of Presentation
      大阪市
    • Related Report
      2013 Final Research Report
  • [Presentation] 心臓の生老病死におけるWntシグナルの役割2013

    • Author(s)
      内藤篤彦
    • Organizer
      北海道カルディアックセミナー
    • Place of Presentation
      札幌・札幌グランドホテル
    • Related Report
      2013 Annual Research Report
  • [Presentation] Wnt signaling in the Heart ~From the Cradle to the Grave~2013

    • Author(s)
      Atsuhiko Naito
    • Organizer
      河口湖カンファレンス
    • Place of Presentation
      東京・ザ・キャピトルホテル東急
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 補体C1qはWntシグナル活性化を通じて老化を誘導する2013

    • Author(s)
      内藤篤彦
    • Organizer
      日本薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] The Role of Complement Protein C1q in activation of Wnt signaling during aging2012

    • Author(s)
      内藤篤彦
    • Organizer
      日本臨床分子医学会
    • Place of Presentation
      京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of complement protein C1q in activation of Wnt signaling during aging2012

    • Author(s)
      内藤篤彦
    • Organizer
      日本分子生物学会
    • Place of Presentation
      博多市
    • Related Report
      2013 Final Research Report
  • [Presentation] 補体C1q はWnt シグナル活性 化を通じて老化を誘導する2012

    • Author(s)
      内藤篤彦
    • Organizer
      日本薬理学会
    • Place of Presentation
      博多市
    • Related Report
      2013 Final Research Report
  • [Presentation] C1q-induced Wnt signaling activation in arterial remodeling associated with hypertension2012

    • Author(s)
      内藤篤彦
    • Organizer
      血管生物医学会学術集会
    • Place of Presentation
      徳島市
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規老化因子によるWnt シグナル活性化と血管リモデリング2012

    • Author(s)
      内藤篤彦
    • Organizer
      日本高血圧学会総会
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of complement C1q in activation of Wnt signaling during aging2012

    • Author(s)
      内藤篤彦
    • Organizer
      日本臨床分子医学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] The role of complement C1q in activation of Wnt signaling during aging2012

    • Author(s)
      内藤篤彦
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] C1q-induced Wnt signaling activation in arterial remodeling associated with hypertension2012

    • Author(s)
      内藤篤彦
    • Organizer
      血管生物医学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 新規老化因子によるWntシグナル活性化と血管リモデリング2012

    • Author(s)
      内藤篤彦
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Annual Review 循環器 20132013

    • Author(s)
      内藤篤彦
    • Total Pages
      285
    • Publisher
      中外医薬社
    • Related Report
      2013 Final Research Report
  • [Book] 慢性炎症と生活習慣病2013

    • Author(s)
      内藤篤彦
    • Total Pages
      175
    • Publisher
      南山堂
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Book] Annual Review循環器20132013

    • Author(s)
      内藤篤彦
    • Total Pages
      285
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] Novel Therapeutic Targets and Strategies against Myocardial Diseases. (In Hill J, Willerson JT, Ryburn FM, Olson E, Welch RA (Eds.)), MUSCLE FUNDAMENTAL BIOLOGY AND MECHANSIMS OF DISEASE2012

    • Author(s)
      Naito AT, Shiojima I, Komuro I
    • Publisher
      Elsevier Inc
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.cvrm.med.osaka-u.ac.jp/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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