| Project/Area Number |
23659421
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKI Toshihiro 九州大学, 大学院・医学研究院, 教授 (80311843)
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| Project Period (FY) |
2012 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分子血管病態学 / 低酸素応答系 / 生活習慣病 / prolyl hydroxylase / 脂肪細胞 / 耐糖能 / 肥満 / hypoxia-inducible factor / アンジオテンシンII受容体 / 細胞肥大 / 線維化 |
|---|
| Research Abstract |
Inhibition of prolyl hydorxlyase (PHD), an oxygen sensor, suppressed anigotensin II receptor expression in vascular smooth muscle cells and angiotensin II-induced cardiac fibrosis. Mice with targeted deletion of PHD isoform 2 in adipocytes were resistant to high-fat diet-induced obesity and glucose intolerance. PHD inhibition may be a novel strategy for the treatment of cardiovascular diseases and metabolic syndrome.
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