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Identification of individuals with augmented functions of blood pressure-lowering peptides

Research Project

Project/Area Number 23659422
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Miyazaki

Principal Investigator

KATO Johji  宮崎大学, フロンティア科学実験総合センター, 教授 (20274780)

Co-Investigator(Kenkyū-buntansha) 桑迫 健二  宮崎大学, フロンティア科学実験総合センター, 准教授 (20381098)
北村 和雄  宮崎大学, 医学部, 教授 (50204912)
鶴田 敏博  宮崎大学, 医学部, 講師 (10389570)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsナトリウム利尿ペプチド / アドレノメデュリン / 機能増強個体 / 心血管疾患 / 慢性腎臓病 / 疾患マーカー / 降圧ペプチド / ANP / BNP / 機能増強 / 高血圧 / 腎疾患
Research Abstract

The aims of the present study are to identify individuals protected from cardiovascular or renal diseases by augmented functions of the hypotensive peptides, ANP, BNP, and adrenomedullin (AM), through the regular health check-up program, and to clarify the mechanisms. First, we found healthy residents who had shown relatively higher plasma levels of ANP or BNP, but not developed hypertension, and currently we continue to follow-up those individual while increasing the number of samples. Second, examining the relationship between the plasma levels of hypotensive peptides and development of chronic kidney disease (CKD), we found that the higher the peptide levels, the more frequent the future development of CKD. This suggests a possibility for those hypotensive peptides as markers of CKD development.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (62 results)

All 2014 2013 2012 2011 Other

All Journal Article (33 results) (of which Peer Reviewed: 32 results) Presentation (19 results) Book (3 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Gender difference in relationship between body mass index and development of chronic kidney disease2013

    • Author(s)
      Komura H, Nomura I, Kitamura K, Kuwasako K, Kato J
    • Journal Title

      BMC Res Notes

      Volume: 6 Issue: 1 Pages: 463-463

    • DOI

      10.1186/1756-0500-6-463

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced fractional shortening of right ventricular outflow tract is associated with adverse outcomes in patients with left ventricular dysfunction2013

    • Author(s)
      Yamaguchi M, Tsuruda T, Watanabe Y, Onitsuka H, Furukawa K, Ideguchi T, Kawagoe J, Ishikawa T, Kato J, Takenaga M, Kitamura K
    • Journal Title

      Cardiovasc Ultrasound

      Volume: 11 Pages: 19-19

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681625/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Big angiotensin-25 : A novel glycosylated angiotensin-related peptide isolated from human urine2013

    • Author(s)
      Nagata S, Hatakeyama K, Asami M, Tokashiki M, Hibino H, Nishiuchi Y, Kuwasako K, Kato J, Asada Y, Kitamura K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Issue: 4 Pages: 757-762

    • DOI

      10.1016/j.bbrc.2013.10.124

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension2013

    • Author(s)
      Moniwa N, Varagic J, Ahmad S, VonCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM
    • Journal Title

      Hypertension

      Volume: 61 Issue: 2 Pages: 417-724

    • DOI

      10.1161/hypertensionaha.112.201889

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide response to antihypertensive medication using home blood pressure measurements: A pilot study nested within the HOMED-BP study2013

    • Author(s)
      Kamide K, Asayama K, Katsuya T, Ohkubo T, Hirose T, Inoue R, Metoki H, Kikuya M, Obara T, Hanada H, Thijs L, Kuznetsova T, Noguchi Y, Sugimoto K, Ohishi M, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Higaki J, Matsuura H, Shinagawa T, Sasaguri T, Miki T, Takeda K, Shimamoto K, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Miyata T, Tomoike H, Kawano Y, Ogihara T, Rakugi H, Staessen JA, Imai Y
    • Journal Title

      Pharmacogenomics

      Volume: 14 Issue: 14 Pages: 1709

    • DOI

      10.2217/pgs.13.161

    • URL

      https://pure.teikyo.jp/en/publications/c85d1b26-a0cb-42d3-89b0-92922a561e9f

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Obesity paradox in peripheral vascular disease2013

    • Author(s)
      Kato J
    • Journal Title

      Atherosclerosis

      Volume: 229 Issue: 2 Pages: 509-510

    • DOI

      10.1016/j.atherosclerosis.2013.05.004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functions of third extracellular loop and helix 8 of family B GPCRs complexed with RAMPs and characteristics of their receptor tafficking2013

    • Author(s)
      Kuwasako K, Hay DL, Nagata S, Murakami M, Kitamura K, Kato J.
    • Journal Title

      Curr Protein Pept Sci

      Volume: 14 Issue: 5 Pages: 416-428

    • DOI

      10.2174/13892037113149990058

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced fractional shortening of right ventricular outflow tract is associated with adverse outcomes in patients with left ventricular dysfunction.2013

    • Author(s)
      Yamaguchi M, Tsuruda T, Watanabe Y, Onitsuka H, Furukawa K, Ideguchi T, Kawagoe J, Ishikawa T, Kato J, Takenaga M, Kitamura K.
    • Journal Title

      Cardiovasc Ultrasound

      Volume: 11 Pages: 19-19

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己紹介と生理活性ペプチド研究紹介2013

    • Author(s)
      加藤丈司
    • Journal Title

      宮崎県内科医会誌

      Volume: 84 Pages: 2-6

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Effects of proangiotensin-12 infused continuously over 14days in conscious rats2012

    • Author(s)
      Komatsu Y, Kida N, Nozaki N, Kuwasako K, Nagata S, Kitamura K, Kato J
    • Journal Title

      Eur J Pharmacol

      Volume: 683 Issue: 1-3 Pages: 186-189

    • DOI

      10.1016/j.ejphar.2012.02.037

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling2012

    • Author(s)
      Kuwasako K, Hay DL, Nagata S, Hikosaka T, Kitamura K, Kato J
    • Journal Title

      Br J Pharmacol

      Volume: 166 Issue: 1 Pages: 137-150

    • DOI

      10.1111/j.1476-5381.2011.01803.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of the single transmembrane domain of human receptor activity-modifying protein 3 in adrenomedullin receptor internalization2012

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Nozaki N, Kato J
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Issue: 3 Pages: 582-587

    • DOI

      10.1016/j.bbrc.2012.03.037

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system2012

    • Author(s)
      Nagata S, Kato J, Kuwasako K, Asami M, Kitamura K
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 2 Pages: 234-238

    • DOI

      10.1038/hr.2011.165

    • NAID

      10030643913

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential blood pressure reductions by angiotensin receptor blocker plus calcium channel blocker or diuretic in elderly hypertension with or without obesity2012

    • Author(s)
      Kato J, Yokota N, Tamaki N, Kariya S, Kita T, Ayabe T, Eto T, Kitamura K
    • Journal Title

      J Am Soc Hypertens

      Volume: 6 Issue: 6 Pages: 393-398

    • DOI

      10.1016/j.jash.2012.09.001

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G protein-coupled receptors2012

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Sano H, Kume K, Ozaki M, Hiraguchi T, Shiotani H, Terajima S, Nakamura Y, Mori K, Yoshida M, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 3 Pages: 177-177

    • DOI

      10.3389/fendo.2012.00177

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three-year safety and effectiveness of fixed-dose losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension under clinical setting (PALM-1 Extension Study).2012

    • Author(s)
      Kita T, Yokota N, Ichiki Y, Ayabe T, Etoh T, Tamaki N, Kato J, Eto T, Kitamura K.
    • Journal Title

      Clin Exp Hypertens

      Volume: 34 Issue: 7 Pages: 498-503

    • DOI

      10.3109/10641963.2012.666606

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sarcoidosis Manifesting as Cardiac Sarcoidosis and Massive Splenomegaly2012

    • Author(s)
      Kawano S, Kato J, Kawano N, Yoshimura Y, Masuyama H, Fukunaga T, Shimao Y, Mihara K, Ueda A, Toyoda K, Imamura T, Kitamura K.
    • Journal Title

      Internal Medicine

      Volume: 51 Issue: 1 Pages: 65-69

    • DOI

      10.2169/internalmedicine.51.5247

    • NAID

      130002062410

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドローム対策としての特定健診の有用性-清武町研究-2012

    • Author(s)
      野﨑尚美、木田信章、桑迫健二、北村和雄、加藤丈司
    • Journal Title

      宮崎県医師会医学会誌

      Volume: 36 Pages: 14-18

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] アドレノメデュリンと関連ペプチド2012

    • Author(s)
      加藤丈司
    • Journal Title

      血圧

      Volume: 19 Pages: 890-894

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Shared and separate functions of the RAMP-based adrenomedullin receptors2011

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Takei Y, Kato J
    • Journal Title

      Peptides

      Volume: 32 Issue: 7 Pages: 1540-1550

    • DOI

      10.1016/j.peptides.2011.05.022

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the endogenous cysteine-rich peptide trissin, ligand for an orphan G-protein-coupled receptor in Drosophila2011

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Yoshizawa-Kumagae K, Nishio H, Kato J, Murakami N, Miyazato M, Kangawa K, Kojima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414 Issue: 1 Pages: 44-48

    • DOI

      10.1016/j.bbrc.2011.09.018

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor2011

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Kato J
    • Journal Title

      Peptides

      Volume: 32 Issue: 1 Pages: 144-149

    • DOI

      10.1016/j.peptides.2010.10.005

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila2011

    • Author(s)
      Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozak Mi, Hiraguchi T, Maeda T, Shiotani H, Terajima S, Sano H, Mori K, Yoshida M, Miyazato M, Kato J, Murakami N, Kangawa K, Kojima M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Issue: 4 Pages: 872-877

    • DOI

      10.1016/j.bbrc.2011.06.081

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertension2011

    • Author(s)
      Kato J, Yokota N, Tamaki N, Kariya S, Kita T, Ayabe T, Eto T, Kitamura K
    • Journal Title

      Hypertens Res

      Volume: 34 Issue: 3 Pages: 331-335

    • DOI

      10.1038/hr.2010.233

    • NAID

      10031163177

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin in hypertension and obesity2011

    • Author(s)
      Kato J, Kuwasako K, Kitamura K
    • Journal Title

      Curr Hypertens Rev

      Volume: 7 Issue: 4 Pages: 257-267

    • DOI

      10.2174/157340211799304770

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis of adrenomedullin 1 receptor function and its roles in the cardiovascular system2011

    • Author(s)
      Kuwasako K, Kitamura K, Nagata S, Kato J
    • Journal Title

      Curr Hypertens Rev

      Volume: 7 Issue: 4 Pages: 207-216

    • DOI

      10.2174/157340211799304743

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertension.2011

    • Author(s)
      Kato J, et al.
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 331-335

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin in Hypertension and Obesity.2011

    • Author(s)
      Kato J, et al.
    • Journal Title

      Curr Hypertens Rev

      Volume: 7 Pages: 257-267

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular basis of adrenomedullin 1 receptor function and its roles in the cardiovascular system.2011

    • Author(s)
      Kuwasako K, et al.
    • Journal Title

      Curr Hypertens Rev

      Volume: 7 Pages: 207-216

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila.2011

    • Author(s)
      Ida T, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 414 Pages: 44-48

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila.2011

    • Author(s)
      Ida T, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Pages: 872-877

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Shared and separate functions of the RAMP-based adrenomedullin receptors.2011

    • Author(s)
      Kuwasako K, et al.
    • Journal Title

      Peptides

      Volume: 32 Pages: 1540-1550

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor.2011

    • Author(s)
      Kuwasako K, et al.
    • Journal Title

      Peptides

      Volume: 32 Pages: 144-149

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 地域一般住民における血中アルドステロン値の規定因子およびインスリン感受性との関連2011

    • Author(s)
      野村郁夫、他
    • Organizer
      第15回日本心血管内分泌代謝学会
    • Place of Presentation
      豊中市
    • Related Report
      2011 Research-status Report
  • [Presentation] メタボリックシンドローム対策としての特定健診の有用性(清武町研究)2011

    • Author(s)
      野崎尚美、他
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮市
    • Related Report
      2011 Research-status Report
  • [Presentation] 2つのアドレノメデュリン(AM)受容体の活性化を規定する責任領域の特定と特徴化:CGRP受容体と異なる新たな活性化機構2011

    • Author(s)
      桑迫健二、他
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮市
    • Related Report
      2011 Research-status Report
  • [Presentation] G蛋白共役型受容体キナーゼ(GRK)の新作用:GRK4とGRK5による1型アドレノメデュリン受容体(AM1受容体)の細胞膜輸送と細胞内シグナリングの強力な抑制2011

    • Author(s)
      桑迫健二、他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Related Report
      2011 Research-status Report
  • [Presentation] Olmesartan + CCB vs Olmesartan + Diuretic as Combination Therapy for Elderly Hypertensive Patients.2011

    • Author(s)
      Johji Kato, et al
    • Organizer
      American Society of Hypertension 26th Annual
    • Place of Presentation
      ニューヨーク市
    • Related Report
      2011 Research-status Report
  • [Presentation] Effects of chronically infused proangiotensin-12 in conscious rats

    • Author(s)
      Johji Kato, Yoichi Komatsu, Kenji Kuwasako, Kazuo Kitamura
    • Organizer
      23rd European Meeting on Hypertension & Cardiovascular Protection
    • Place of Presentation
      Milan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Benefits of the specific health checkups and guidance program in reducing metabolic syndrome in Japan: from the Kiyotake study

    • Author(s)
      Johji Kato, Naomi Nozaki, Kenji Kuwasako, Kazuo Kitamura
    • Organizer
      23rd European Meeting on Hypertension & Cardiovascular Protection
    • Place of Presentation
      Milan
    • Related Report
      2013 Annual Research Report
  • [Presentation] 清武町における特定健診のメタボリックシンドローム改善効果

    • Author(s)
      野崎尚美、桑迫健二、北村和雄、加藤丈司
    • Organizer
      第2回臨床高血圧フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] G蛋白共役型受容体(GPCR)の重要な細胞内シグナル分子、β-アレスチンの新規作用:1型アドレノメデュリン(AM)受容体の細胞内移行の負の制御

    • Author(s)
      桑迫健二、北村和雄、永田さやか、野崎尚美、加藤丈司
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肥満の有無による降圧併用療法の効果とアルドステロン濃度変化の差異

    • Author(s)
      加藤丈司、桑迫健二、北 俊弘、北村和雄
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 当院で経験した、60才以下発症の悪性高血圧7症例について

    • Author(s)
      上園繁弘、北 俊弘、加藤丈司、北村和雄
    • Organizer
      第2回臨床高血圧フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肥満およびBMIと慢性腎臓病(CKD)発症との関連における性差

    • Author(s)
      野村郁夫、小村浩史、北村和雄、桑迫健二、加藤丈司
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 家畜グレリンの単離精製と分子型の同定

    • Author(s)
      富永初美、岩元絵里、井田隆徳、保田昌宏、桑野睦敏、児島将康、宮里幹也、寒川賢治、加藤丈司
    • Organizer
      第17回日本心血管内分泌代謝学会
    • Place of Presentation
      豊中
    • Related Report
      2013 Annual Research Report
  • [Presentation] ARB plus CCB or Diuretic as a Combination Therapy for Elderly Hypertensive Patients with or without Obesity.

    • Author(s)
      Johji Kato, Naoto Yokota, Toshihiro Kita, Tanenao Eto, Kazuo Kitamura.
    • Organizer
      American Society of Hypertension 2012 Annual Scientific Meeting and Exposition.
    • Place of Presentation
      HILTON NEW YORK(アメリカ)
    • Related Report
      2012 Research-status Report
  • [Presentation] 清武町における特定健診の有用性の検討

    • Author(s)
      野崎尚美、桑迫健二、北村和雄、加藤丈司
    • Organizer
      第1回臨床高血圧フォーラム
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2012 Research-status Report
  • [Presentation] アドレノメデュリン(AM)受容体の再感作を促進するストラテジーの確立

    • Author(s)
      桑迫健二、北村和雄、永田さやか、野崎尚美、加藤丈司
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル・名古屋能楽堂(愛知県名古屋市)
    • Related Report
      2012 Research-status Report
  • [Presentation] ARBとカルシウム拮抗薬または利尿薬の併用降圧療法の比較:肥満の有無による降圧効果とアルドステロン濃度変化の差異

    • Author(s)
      加藤丈司、桑迫健二、北 俊弘、北村和雄
    • Organizer
      第16回日本心血管内分泌代謝学会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] G蛋白共役型受容体キナーゼ(GRK)によるアドレノメデュリン(AM)シグナル抑制

    • Author(s)
      桑迫健二、北村和雄、永田さやか、加藤丈司
    • Organizer
      第85回日本内分泌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Related Report
      2012 Research-status Report
  • [Presentation] メタボリックシンドローム対策としての特定健診の有用性(清武町研究)

    • Author(s)
      野崎尚美、桑迫健二、北村和雄、加藤丈司
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル・名古屋能楽堂(愛知県名古屋市)
    • Related Report
      2012 Research-status Report
  • [Book] Adrenomedullin Peptides. In : Kastin AJ, ed. Handbook of Biologically Active Peptides2013

    • Author(s)
      Kato J, Kitamura K
    • Publisher
      Academic Press, San Diego
    • Related Report
      2013 Final Research Report
  • [Book] Handbook of Biologically Active Peptides2013

    • Author(s)
      Kato J, Kitamura K
    • Total Pages
      1942
    • Publisher
      Academic Press
    • Related Report
      2013 Annual Research Report
  • [Book] ペプチド医薬の最前線2012

    • Author(s)
      井田隆徳,児島将康,加藤丈司
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.miyazaki-u.ac.jp/peptides/katou/jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 宮崎大学フロンティア科学実験総合センター生理活性物質探索病態解析分野

    • URL

      http://www.med.miyazaki-u.ac.jp/peptides/katou/jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.miyazaki-u.ac.jp/peptides/katou/jp/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 急性腎障害に起因する多臓器不全の予防又は治療薬2014

    • Inventor(s)
      池田正浩、園田紘子,北村和雄,加藤丈司
    • Industrial Property Rights Holder
      国立大学法人宮崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-036815
    • Filing Date
      2014-02-27
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 長時間作用型アドレノメデュリン誘導体2014

    • Inventor(s)
      北村和雄,加藤丈司,久保恵是,桑迫健二,久保茂,熊谷久美子
    • Industrial Property Rights Holder
      国立大学法人宮崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-058225
    • Filing Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 急性腎障害に起因する多臓器不全の予防又は治療薬2014

    • Inventor(s)
      池田正浩、園田紘子、北村和雄、加藤丈司
    • Industrial Property Rights Holder
      宮崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-036815
    • Filing Date
      2014-02-27
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 長時間作用型アドレノメデュリン誘導体2014

    • Inventor(s)
      北村和雄、加藤丈司、桑迫健二、久保恵是、久保、熊谷
    • Industrial Property Rights Holder
      宮崎大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-058225
    • Filing Date
      2014-03-20
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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