Novel role of basophil in chronic hypersensitivity pneumonitis
| Project/Area Number |
23659429
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
INASE Naohiko 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60262185)
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| Co-Investigator(Kenkyū-buntansha) |
KARASUYAMA Hajime 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60195013)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 過敏性肺炎 / 好塩基球除去 / 肺線維化 / マウスモデル |
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| Research Abstract |
Pigeon dropping extract(PDE) induced chronic hypersensitivity pneumonitis model using A/J mice and BALB/c mice was prepared. Basophil specific monoclonal antibody(anti-CD200R3、Ba103) was injected to the mice one day before challenge of PDE every week during the following four weeks to deplete basophils, Specimens for pathological findings, collagen contents, and mRNA expression of several cytokines were prepared.
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Report
(2 results)
Research Products
(20 results)
