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Novel role of basophil in chronic hypersensitivity pneumonitis

Research Project

Project/Area Number 23659429
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

INASE Naohiko  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60262185)

Co-Investigator(Kenkyū-buntansha) KARASUYAMA Hajime  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (60195013)
Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords過敏性肺炎 / 好塩基球除去 / 肺線維化 / マウスモデル
Research Abstract

Pigeon dropping extract(PDE) induced chronic hypersensitivity pneumonitis model using A/J mice and BALB/c mice was prepared. Basophil specific monoclonal antibody(anti-CD200R3、Ba103) was injected to the mice one day before challenge of PDE every week during the following four weeks to deplete basophils, Specimens for pathological findings, collagen contents, and mRNA expression of several cytokines were prepared.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (20 results)

All 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 6 results) Presentation (4 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Th2-biased immune responses areimportant in a murine model of chronichypersensitivity pneumonitis2011

    • Author(s)
      Mitaka K, Miyazaki Y, Yasui M, Furuie M, Miyake S, Inase N, Yoshizawa Y
    • Journal Title

      IntArch Allergy Immunol

      Volume: 154 Pages: 264-274

    • Related Report
      2011 Final Research Report
  • [Journal Article] Serial high-resolutioncomputed tomography findings of acuteand chronic hypersensitivitypneumonitis induced by avian antigen2011

    • Author(s)
      Tateishi T, Ohtani Y, Takemura T, Akashi T, Miyazaki Y, Inase N, Yoshizawa Y
    • Journal Title

      J Comput Assist Tomogr

      Volume: 35 Pages: 272-279

    • Related Report
      2011 Final Research Report
  • [Journal Article] Identification of fungal DNA in BALF from patients withhome-related hypersensitivitypneummonitis2011

    • Author(s)
      Unoura K, Miyazaki Y, Sumi Y, Tamaoka M, Sugita T, Inase N
    • Journal Title

      Respir Med

      Volume: 105 Pages: 1-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] hypersensitivity pneumonitis2011

    • Author(s)
      Kuramochi J, Inase N, Miyazaki Y, Kawachi H, Takemura T, Yoshizawa Y
    • Journal Title

      Respiration

      Volume: 82 Pages: 263-267

    • NAID

      40019140328

    • Related Report
      2011 Final Research Report
  • [Journal Article] Successfuldiagnosis of a combined thymicepithelial tumor by endobronchialultrasound-guided transbronchialneedle aspiration2011

    • Author(s)
      Okamoto T, Miyazaki Y, Sakakibara Y, Tamaoka M, Sumi Y, Inase N
    • Journal Title

      J Med Dent Sci

      Volume: 58 Pages: 123-126

    • Related Report
      2011 Final Research Report
  • [Journal Article] Proteome analysisof bronchoalveolar lavage fluid inchronic hypersensitivity pneumonitis2011

    • Author(s)
      Okamoto T, Miyazaki Y, Shirahama R, Tamaoka M, Inase N
    • Journal Title

      Allergol Int

      Volume: 61 Pages: 83-92

    • Related Report
      2011 Final Research Report
  • [Journal Article] Th2-biased immune responses are important in a murine model of chronic hypersensitivity pneumonitis2011

    • Author(s)
      Mitaka K
    • Journal Title

      Int Arch Allergy Immunol

      Volume: Vol.154 Pages: 264-274

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial high-resolution computed tomography findings of acute and chronic hypersensitivity pneumonitis induced by avian antigen2011

    • Author(s)
      Tateishi T
    • Journal Title

      J Comput Assist Tomogr

      Volume: Vol.35 Pages: 272-279

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of fungal DNA in BALF from patients with home-related hypersensitivity pneumonitis2011

    • Author(s)
      Unoura K
    • Journal Title

      Respir Med

      Volume: Vol.105 Pages: 1-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung cancer in chronic hypersensitivity pneumonits2011

    • Author(s)
      Kuramochi J
    • Journal Title

      Respiration

      Volume: Vol.82 Pages: 263-267

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration2011

    • Author(s)
      Okamoto T
    • Journal Title

      J Med Dent Sci

      Volume: Vol.58 Pages: 123-126

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteome analysis of bronchoalveolar lavage fluid in chronic hypersensitivity pneumonitis2011

    • Author(s)
      Okamoto T
    • Journal Title

      Allergol Int

      Volume: Vol.61 Pages: 83-92

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 慢性鳥関連過敏性肺炎の臨床病理学的検討2011

    • Author(s)
      千葉佐保子
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      グランドプリンスホテル高輪(東京)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性過敏性肺炎における上皮間葉転換(epithelial mesenchymal transition、EMT)の検討2011

    • Author(s)
      安井牧人、宮崎泰成、土屋公威、玉岡明洋、坂下博之、角勇樹、稲瀬直彦
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Related Report
      2011 Final Research Report
  • [Presentation] 鳥関連過敏性肺炎における特異抗体の測定2011

    • Author(s)
      稲瀬直彦、鵜浦康司、安井牧人、宮崎泰成
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性鳥関連過敏性肺炎の臨床病理学的検討2011

    • Author(s)
      千葉佐保子、土屋公威、藤江俊秀、玉岡明洋、坂下博之、角勇樹、宮崎泰成、武村民子、稲瀬直彦
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Related Report
      2011 Final Research Report
  • [Book] EBM呼吸器疾患の治療2011

    • Author(s)
      稲瀬直彦、吉澤靖之:過敏性肺炎.永井厚志、大田健、江口研二、橋本修編
    • Publisher
      中外医学社、東京
    • Related Report
      2011 Final Research Report
  • [Book] EBM呼吸器疾患の治療2011-20122011

    • Author(s)
      稲瀬直彦
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/pulm/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/pulm/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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