Development of inhaled therapy with anti-fibrotic peptides for pulmonary fibrosis
| Project/Area Number |
23659434
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
NISHIOKA Yasuhiko 徳島大学, ヘルスバイオサイエンス研究部, 教授 (70274199)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KISHI Jun 徳島大学, 大学病院, 助手 (20437635)
AZUMA Momoyo 徳島大学, 大学病院, 特任助教 (10403750)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 肺線維症 / ペプチド / 吸入療法 / PDGF / 医療・福祉 |
|---|
| Research Abstract |
We synthesized novel peptides which could inhibit the binding of mouse PDGF-BB to PDGFRbeta. From these peptides, we identified the peptide No.3 showing the strong inhibitory effects of the proliferation of lung fibroblasts in vitro. The FAM-labelled peptide No. 3 strongly bound to lung fibroblasts under a fluorescence microscopy. The administration of peptide No.3 as an inhaled therapy reduced bleomycin-induced lung fibrosis in mice. These results suggest that the peptide might be a novel and promising therapeutic agent for pulmonary fibrosis.
|
Report
(4 results)
Research Products
(99 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Immunoglobulin G4-related lung disease: clinicoradiological and pathological features.2013
Author(s)
Matsui S, Hebisawa A, Sakai F, Yamamoto H, Terasaki Y,,, Kurihara Y, Waseda Y, Kawamura T, Miyashita T, Inoue H, Hata N, Kawabata Y, Ogura T
-
Journal Title
Respirology
Volume: 18
Issue: 3
Pages: 480-487
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Antifibrotic effects of focal adhesion klinase inhibitor in bleomycin-induced pulmonary fibrosis in mice.2013
Author(s)
Kinoshita K, Aono Y, Azuma M, Kishi J, Takezaki A, Kishi M, Makino H, Okazaki H, Uehara H, Izumi K, Sone S, Nishioka Y
-
Journal Title
Am J Respir Cell Mol Biol
Volume: 49
Issue: 4
Pages: 536-543
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Pleural mesothelioma instigates tumor associated fibroblasts to promote prog-ression via malignant cytokine network2011
Author(s)
Li Q, Wang W, Yamada T, Matsumoto K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yano S.
-
Journal Title
Am J Pathol
Volume: 179
Issue: 3
Pages: 1483-93
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Antifibrotic effects of focal adhesion kinase inhibitor in bleomycin-induced pulmonary fibrosis in mice.
Author(s)
Katsuhiro Kinoshita, Yoshinori Aono, Hisatsugu Goto, Momoyo Azuma, Akio Takezaki, Terumi Yoshijima, Masami Kishi, Jun Kishi, Yuko Toyoda, Hiroshi Kawano, Syuichi Abe, Toshifumi Tezuka, Hisanori Uehara, Keisuke Izumi, Yasuhiko Nishioka
Organizer
18th Congress of the Asian Pacific Society of Respirology
Place of Presentation
パシフィコ横浜（神奈川県）
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
