| Project/Area Number |
23659438
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI Takefumi 東北大学, 大学院・医学系研究科, 准教授 (40375001)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Sadayoshi 東北大学, 大学院・医学系研究科, 教授 (40271613)
高橋 信行 東北大学, 薬学研究科(研究院), 准教授 (40588456)
金田 朋洋 東北大学, 大学病院, 講師 (50323019)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Nobuyuki 東北大学, 大学院・薬学研究科, 准教授 (40588456)
KANETA Tomohiro 東北大学, 病院, 講師 (50323019)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腎臓病 / 低酸素 / prolyl hydroxylase / 虚血 / 酸化ストレス / ノックアウトマウ ス / ミトコンドリア / ノックアウトマウス / 腎血流 |
|---|
| Research Abstract |
Hypoxia induced mitochondrial oxidative stress in renal medullary thick ascending limb of loop of Henle. Treatment with Mito-TEMPO significantly attenuated the reduction of renal medullary blood flow induced by ischemia/reperfusion. We established methods to evaluate renal function with [^<15>O]H_2O-PET and [^<18>F]FRP-170-PET. We created conditional prolyl hydroxylase (PHD) knockout mice, and measured the response of renal medullary blood flow in those mice. These results indicated that hypoxia could exacerbate renal injury though increase of mitochondrial oxidative stress and following reduction of renal medullary blood flow.
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