• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identifying the genetic causality of familial IgAN by a new analysis system

Research Project

Project/Area Number 23659441
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionNiigata University

Principal Investigator

NARITA Ichiei  新潟大学, 医歯学系, 教授 (20272817)

Co-Investigator(Kenkyū-buntansha) GOTO Shin  新潟大学, 医歯学系, 講師 (00463969)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIgA腎症 / ゲノム / 連鎖解析 / 家族性 / エクソーム解析 / EEA1 / SNP / 糖鎖不全 / 慢性糸球体腎炎 / 次世代シークエンサ
Research Abstract

To identify the genetic causality of familial IgAN, we applied exome sequencing to a family comprising four biopsy-proven IgAN patients. Genome-wide linkage analysis was concurrently carried out. Thirteen variants which were shared only by affected individuals in the family were selected as candidate genes for familial IgAN. Linkage analysis of the family revealed linkage signals at nine loci, and among the candidates, a novel missense variant F161Y in EEA1, encoding Early Endosome Antigen 1. Furthermore, the F161Y variant completely co-segregated in the family and this variant is existed in the highly conserved region across zebrafish to human. Resequence analysis of EEA1 revealed that among additional 27 familial IgAN, six families carried the other three variants within EEA1. Frequencies of these EEA1 variants in familial IgAN was significantly higher than those in The Human Genetic Variation Database, indicating that EEA1 gene is a susceptibility gene for Japanese familial IgAN.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (77 results)

All 2014 2013 2012 2011

All Journal Article (52 results) (of which Peer Reviewed: 52 results) Presentation (14 results) (of which Invited: 4 results) Book (11 results)

  • [Journal Article] Expression of tight junction protein claudin-1 in human crescentic glomerulonephritis2014

    • Author(s)
      Koda R, Yoshino A, manishi Y, Kawamoto S, Ueda Y, Yaoita E, Kazama JJ, Narita I, Takeda T
    • Journal Title

      Intern J Nephrol

      Volume: (Epub)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the p.E66Q variant of GLAin the progression of chronic kidney disease2014

    • Author(s)
      WatanabeH, Goto S, Miyashita A, Maruyama H, Wakasugi M, Yokoseki A, Kuwano R, Narita I
    • Journal Title

      Clin Exp Nephrol

      Volume: (Epub)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High rates of death and hospitalization follow bone fracture among hemodialysis patients2014

    • Author(s)
      Wakasugi M, Kazama JJ, Narita I
    • Journal Title

      Kidney Int

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of warfarin use and incidence of ischemic stroke in Japanese hemodialysis patients with chronic sustained atrial fibrillation : A prospective cohort study2014

    • Author(s)
      Wakasugi M, Kazama JJ, Narita I, et al.
    • Journal Title

      Clin Exp Nephrol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice2014

    • Author(s)
      Tsuchida Y, Kaneko Y, Otsuka T, Goto K, Saito A, Yamamoto K, Yamamoto T, Narita I
    • Journal Title

      Clin Exp Nephrol

      Volume: 18 Pages: 65-74

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of donor-recipient age difference on long-term graft survival in living kidney transplantation2014

    • Author(s)
      Tasaki M, Saito K, Nakagawa Y, Ikeda M, Imai N, Narita I, Takahashi K
    • Journal Title

      International Urology and Nephrology

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Budget impact analysis of chronic kidney disease mass screening test in Japan2014

    • Author(s)
      Kondo M, Yamagata K, Hoshi SL, Saito C, Asahi K, Moriyama T, Tsuruya K, Konta T, Fujimoto S, Narita I, Kimura K, Iseki K, Watanabe T
    • Journal Title

      Clin Exp Nephrol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of interleukin-6 receptor inhibition therapy on periodontal condition in patients with rheumatoid arthritis and chronic periodontitis2014

    • Author(s)
      Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H
    • Journal Title

      J Periodontol

      Volume: 85 Pages: 57-67

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A hip fracture in a dialysis patient with Abeta2M amyloidosis2014

    • Author(s)
      Kazama JJ, Yamamoto S, Wakasugi M, Narita I
    • Journal Title

      Kidney Int

      Volume: 85 Pages: 214-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of tight junction protein claudin-1 in human crescentic glomerulonephritis," by submitted to International2014

    • Author(s)
      Koda R, Yoshino A, manishi Y, Kawamoto S, Ueda Y, Yaoita E, Kazama JJ, Narita I, Takeda T
    • Journal Title

      Journal of Nephrology

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the p.E66Q variant of GLA in the progression of chronic kidney disease2014

    • Author(s)
      Watanabe H, Goto S, Miyashita A, Maruyama H, Wakasugi M, Yokoseki A, Kuwano R, Narita I
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High rates of death and hospitalization follow bone fracture among hemodialysis patients2014

    • Author(s)
      Wakasugi M, Kazama JJ, Narita I
    • Journal Title

      Kidney International

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of prolactin receptor in proximal tubular cells was induced in cardiac dysfunction model mice.2014

    • Author(s)
      Tsuchida Y, Kaneko Y, Otsuka T, Goto K, Saito A, Yamamoto K, Yamamoto T, Narita I
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 18 Issue: 1 Pages: 65-74

    • DOI

      10.1007/s10157-013-0820-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A hip fracture in a dialysis patient with Abeta2M amyloidosis2014

    • Author(s)
      Kazama JJ, Yamamoto S, Wakasugi M, Narita I
    • Journal Title

      Kidney International

      Volume: 85 Issue: 1 Pages: 214-215

    • DOI

      10.1038/ki.2013.412

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A combination of healthy lifestyle factors is associated with a decreased incidence of chronic kidney disease : a population-based cohort study2013

    • Author(s)
      Wakasugi M, Kazama JJ, Yamamoto S, Kawamura K, Narita I
    • Journal Title

      Hypertens Res

      Volume: 36 Pages: 328-33

    • NAID

      120006745611

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cause-specific excess mortality among dialysis patients : comparison with the general population in Japan2013

    • Author(s)
      Wakasugi M, Kazama JJ, Yamamoto S, Kawamura K, Narita I
    • Journal Title

      Ther Apher Dial

      Volume: 17 Pages: 298-304

    • NAID

      120006749445

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased risk of hip fracture among Japanese hemodialysis patients2013

    • Author(s)
      Wakasugi M, Kazama JJ, Taniguchi M,Wada A, Iseki K, Tsubakihara Y, Narita I
    • Journal Title

      J Bone Miner Metab

      Volume: 31 Pages: 315-21

    • NAID

      10031176596

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population2013

    • Author(s)
      Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M,Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F
    • Journal Title

      AmJ HumGenet

      Volume: 93 Pages: 289-97

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The clinical course of patients with IgG4-related kidney disease2013

    • Author(s)
      Saeki T, Kawano M, Mizushima I, Yamamoto M, Wada Y, Nakashima H, Homma N, Tsubata Y, Takahashi H, Ito T, Yamazaki H, Saito T, Narita I
    • Journal Title

      Kidney Int

      Volume: 84 Pages: 826-33

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of male dialysis patients for fabry disease by plasma globotriaosylsphingosine2013

    • Author(s)
      Maruyama H, Takata T, Tsubata Y, Tazawa R, Goto K, Tohyama J, Narita I, Yoshioka H, Ishii S
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 8 Pages: 629-36

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of amyloid deposits in the kidneys of a patient with reactive amyloidosis associated with rheumatoid arthritis2013

    • Author(s)
      Kuroda T, Tanabe N, Sato H, Nakatsue T, Wada Y, Murakami S, Nakano M, Narita I
    • Journal Title

      BMC research notes

      Volume: 6 Pages: 231-231

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells2013

    • Author(s)
      Koshio J, Kagamu H, Nozaki K, Saida Y, Tanaka T, Shoji S, Igarashi N, Miura S, Okajima M, Watanabe S, Yoshizawa H, Narita I
    • Journal Title

      Cancer Immunol Immunother

      Volume: 62 Pages: 1619-28

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of Epstein-Barr virus-related lymphadenopathy mimicking the clinical features of IgG4-related disease2013

    • Author(s)
      Wada Y, Kojima M, Yoshita K, Yamazaki M, Kobayashi D, Murakami S, Nishi S, Nakano M, Narita I
    • Journal Title

      Mod Rheumatol

      Volume: 23 Pages: 597-603

    • NAID

      10031175924

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A combination of healthy lifestyle factors is associated with a decreased incidence of chronic kidney disease: a population-based cohort study2013

    • Author(s)
      Wakasugi M, Kazama JJ, Yamamoto S, Kawamura K, Narita I
    • Journal Title

      Hypertension Research

      Volume: 36 Issue: 4 Pages: 328-333

    • DOI

      10.1038/hr.2012.186

    • NAID

      120006745611

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population2013

    • Author(s)
      Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otsubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I,
    • Journal Title

      American Journal of Human Genetics

      Volume: 93 Issue: 2 Pages: 289-297

    • DOI

      10.1016/j.ajhg.2013.05.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of urinary full-length and ectodomain forms of megalin in patients with type 2 diabetes2012

    • Author(s)
      Ogasawara S, Hosojima M, Kaseda R, Kabasawa H, Yamamoto-Kabasawa K, Kurosawa H, Sato H, Iino N, Takeda T, Suzuki Y, Narita I, Yamagata K, Tomino Y, Gejyo F, Hirayama Y, Sekine S, Saito A
    • Journal Title

      Diabetes Care

      Volume: 35 Pages: 1112-8

    • NAID

      130005454420

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrin alpha1/beta1 and alpha2/beta1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy2012

    • Author(s)
      Kaneko Y, Otsuka T, Tsuchida Y, Gejyo F, Narita I
    • Journal Title

      Int Immunol

      Volume: 24 Pages: 219-32

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Geographic Differences in Genetic Susceptibility to IgA Nephropathy : GWAS Replication Study and Geospatial Risk Analysis2012

    • Author(s)
      Kiryluk K, Li Y, Sanna-Cherchi S, Rohanizadegan M, Suzuki H, Eitner F, Snyder HJ, Narita I, Berthoux F, Floege J, Stengel B, Zhang H, Lifton RP, Gharavi AG
    • Journal Title

      PLoS Genet

      Volume: 8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the local and national prevalences of chronic kidney disease based on annual health check program data2012

    • Author(s)
      Wakasugi M, Kazama JJ, Narita I
    • Journal Title

      Clinl Exp Nephrol

      Volume: 16 Pages: 749-54

    • NAID

      10031122262

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Depletion of radio-resistant regulatory T cells enhances antitumor immunity during recovery from lymphopenia2012

    • Author(s)
      Baba J,Watanabe S, Saida Y, Tanaka T, Miyabayashi T, Koshio J, Ichikawa K, Nozaki K, Koya T, Deguchi K, Tan C, Miura S, Tanaka H, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I
    • Journal Title

      Blood

      Volume: 120 Pages: 2417-27

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of Japanese Society for Dialysis Therapy dialysis tables to compare the local and national incidence of dialysis2012

    • Author(s)
      Wakasugi M, Kazama JJ, Narita I
    • Journal Title

      Ther Aphe Dial

      Volume: 16 Pages: 63-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light-microscopic characteristics of IgG4-related tubulointerstitial nephritis : distinction from non-IgG4-related tubulointerstitial nephritis2012

    • Author(s)
      Yoshita K, Kawano M, Mizushima I, Hara S, Ito Y, Imai N, Ueno M, Nishi S, Nomura H, Narita I, Saeki T
    • Journal Title

      Nephrol Dial Transpl

      Volume: 27 Pages: 2755-61

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Histological Analysis of SM22alpha (Transgelin) in an Adriamycin-Induced Focal Segmental Glomerulosclerosis Model2012

    • Author(s)
      Wang X, Sakatsume M, Sakamaki Y, Inomata S, Yamamoto T, Narita I
    • Journal Title

      Nephron Exp Nephrol

      Volume: 120

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of renal administration of a selective cyclooxygenase-2 inhibitor or stable prostaglandin I(2) analog on the progression of sclerotic glomerulonephritis in rats2012

    • Author(s)
      Nozawa Y, Sato A, Piao H, Morioka T, Narita I, Oite T
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Pages: 221-230

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Weight gain after 20 years of age is associated with prevalence of chronic kidney disease2012

    • Author(s)
      Wakasugi M, Narita I, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Kurahashi I, Ohashi Y, Watanabe T
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Pages: 259-68

    • NAID

      10030738881

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.2012

    • Author(s)
      Kiryluk K, Li Y, Rohanizadegan M, Suzuki H, Eitner F, Narita I, Floege J, Stengel B, Zhang H, Lifton RP, Gharavi AG.
    • Journal Title

      PLoS Genet

      Volume: 8 Issue: 6 Pages: e1002765-e1002765

    • DOI

      10.1371/journal.pgen.1002765

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Integrin alpha1/beta1 and alpha2/beta1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy2012

    • Author(s)
      Kaneko Y, et al.
    • Journal Title

      Int Immunol

      Volume: (印刷中) Issue: 4 Pages: 219-232

    • DOI

      10.1093/intimm/dxr125

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significance of Urinary Full-Length and Ectodomain Forms of Megalin in Patients With Type 2 Diabetes2012

    • Author(s)
      Ogasawara S, et al.
    • Journal Title

      Diabetes Care

      Volume: (印刷中) Issue: 5 Pages: 1112-1118

    • DOI

      10.2337/dc11-1684

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Significant association between renal function and amyloid-positive area in renal biopsy specimens in AL amyloidosis.2012

    • Author(s)
      Kuroda T, Tanabe N, Kobayashi D, Wada Y, Murakami S, Nakano M, Narita I.
    • Journal Title

      BMC Nephrol

      Volume: 13 Issue: 1 Pages: 118-118

    • DOI

      10.1186/1471-2369-13-118

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Light-microscopic characteristics of IgG4-related tubulointerstitial nephritis : distinction from non-IgG4-related tubulointerstitial nephritis2012

    • Author(s)
      Yoshita K, et al.
    • Journal Title

      Nephrol Dial Transplant

      Volume: (印刷中) Issue: 7 Pages: 2755-2761

    • DOI

      10.1093/ndt/gfr761

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Injured kidney cells express SM22alpha (transgelin) : Unique features distinct from alpha-smooth muscle actin (alphaSMA)2011

    • Author(s)
      Sakamaki Y, Sakatsume M, Wang X, Inomata S, Yamamoto T, Gejyo F, Narita I
    • Journal Title

      Nephrology

      Volume: 16 Pages: 211-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membranoproliferative pattern of glomerular injury associated with complement component 9 deficiency due to Arg95Stop mutation2011

    • Author(s)
      Miura T, Goto S, Iguchi S, Shimada H, Ueno M, Nishi S, Narita I
    • Journal Title

      Clin Eexp Nephrol

      Volume: 15 Pages: 86-91

    • NAID

      10029004557

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Megalin is downregulated via LPS-TNF-alpha-ERK1/2 signaling pathway in proximal tubule cells2011

    • Author(s)
      Takeyama A, Sato H, Soma-Nagae T, Kabasawa H, Suzuki A, Yamamoto-Kabasawa K, Hosojima M, Kaneko R, Higuchi F, Kaseda R, Ogasawara S, Narita I, Saito A
    • Journal Title

      Biochem Biophys Res Com

      Volume: 407 Pages: 108-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel expression of claudin-5 in glomerular podocytes2011

    • Author(s)
      Koda R, Zhao L, Yaoita E, Yoshida Y, Tsukita S, Tamura A, Nameta M, Zhang Y, Fujinaka H, Magdeldin S, Xu B, Narita I, Yamamoto T
    • Journal Title

      Cell Tissue Res

      Volume: 343 Pages: 637-48

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear chromatin-concentrated osteoblasts in renal bone diseases2011

    • Author(s)
      Kazama JJ, Yamamoto S, Narita I, Kurihara S
    • Journal Title

      Ther Apher Dial

      Volume: 15 Suppl 1 Pages: 9-13

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Earthquake in Japan2011

    • Author(s)
      Kazama JJ, Narita I
    • Journal Title

      Lancet

      Volume: 377 Pages: 1652-3

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The case of BK virus infection in which it was difficult to differentiate from acute rejection2011

    • Author(s)
      Ito Y, Nishi S, Imai N, Yoshita K, Saito K, Nakagawa Y, Takahashi K, Narita I
    • Journal Title

      Clin Transpl

      Volume: 25 Suppl 23 Pages: 44-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of SM22alpha (transgelin) in glomerular and interstitial renal injury2011

    • Author(s)
      Inomata S, Sakatsume M, Sakamaki Y, Wang X, Goto S, Yamamoto T, Gejyo F, Narita I
    • Journal Title

      Nephron Exp Nephrol

      Volume: 117

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy : potential role in mesangial matrix expansion2011

    • Author(s)
      Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Yamada T, Imai N, Narita I, Kawachi H, Polkinghorne KR, Nikolic-Paterson DJ, Uchiyama M
    • Journal Title

      Histopathology

      Volume: 58 Pages: 198-210

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thrombotic thrombocytopenic purpura in IgG4-related disease with severe deficiency of ADAMTS-13 activity and IgG4 autoantibody against ADAMTS-132011

    • Author(s)
      Saeki T, Ito T, Youkou A, Ishiguro H, Sato N, Yamazaki H, Koike T, Kourakata H, Ferrari S, Scheiflinger F, Narita I
    • Journal Title

      Arthritis Care Res

      Volume: 63 Pages: 1209-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of renal administration of a selective cyclooxygenase-2 inhibitor or stable prostaglandin I(2) analog on the progression of sclerotic glomerulonephritis in rats2011

    • Author(s)
      Nozawa Y, et al.
    • Journal Title

      Clin Exp Nephrol

      Volume: (印刷中) Issue: 2 Pages: 221-230

    • DOI

      10.1007/s10157-011-0558-2

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Megalin is downregulated via LPS-TNF-alpha-ERK1/2 signaling pathway in proximal tubule cells2011

    • Author(s)
      Takeyama A, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 407 Issue: 1 Pages: 108-112

    • DOI

      10.1016/j.bbrc.2011.02.118

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] p.E66Q Variant of α-Galactosidase A Does Not Affect the Progression of Chronic Kidney Disease2013

    • Author(s)
      Watanabe H, Goto S, Maruyama H, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Megalin-Mediated Mechanism of High Fat Diet-Induced Kidney Disease2013

    • Author(s)
      Hosojima M, Kuwahara S, Kabasawa H, Aoki H, Kaneko R, Narita I, Saito A
    • Organizer
      American Society of Nephrology Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] IgA腎症の病態と治療2013

    • Author(s)
      成田一衛
    • Organizer
      CKD Special Seminar
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 家族内集積を示す腎疾患のエクソーム解析2013

    • Author(s)
      後藤眞、細道一善、塚口裕康、渡辺博文、井ノ上 逸朗、成田一衛
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IgA腎症感受性の責任遺伝子2013

    • Author(s)
      成田一衛
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IgA腎症の原因を求めて2013

    • Author(s)
      成田一衛
    • Organizer
      第25回栃木腎フォーラム
    • Place of Presentation
      宇都宮市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A methodology for evaluating local care and preventing the progression of CKD2012

    • Author(s)
      Wakasugi W, Kazama JJ, Narita I
    • Organizer
      The 1st Chronic Kidney Disease Frontier in Nagoya
    • Place of Presentation
      Japan
    • Year and Date
      2012-02-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Exome Sequencing Identifies a Novel EEA1 Variant in Japanese Familial IgA Nephropathy2012

    • Author(s)
      Goto S, Hosomichi K, Tsukaguchi H, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Irbesartan decreases serum and urinary MCP-l levels in patients with metablolic svndrome-related nephrology2012

    • Author(s)
      Hosojima M. Kabasawa H, Suzuki Y, Narita I, Saito A
    • Organizer
      ISN FOREFRONTS 2012
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] 次世代シーケンサーを用いた腎臓病研究:家族性IgA腎症のエクソーム解析2012

    • Author(s)
      後藤  眞、細道 一善、塚口 裕康、井ノ上逸朗、成田 一衛
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Genome-wide linkage scan of Japanese families with IgA nephropathy2011

    • Author(s)
      Goto S, Tsukaguchi H, Wada M, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2011
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Prolactin receptor was up-regulated in the proximal tubules of the kidney in the cardio-renal syndrome model mice2011

    • Author(s)
      Tsuchida Y, Kaneko Y, Saito A, Yamamoto T, Narita I
    • Organizer
      American Society of Nephrology Kidney Week 2011
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Integrin α2/β1 as a novel galactose-deficient IgA1 receptor on Human mesangial cells2011

    • Author(s)
      Kaneko Y, et al.
    • Organizer
      World Congress of Nephrology 2011
    • Place of Presentation
      Vancouver Convention Center, (Vancouver, Canada)
    • Related Report
      2011 Research-status Report
  • [Presentation] Membranoproliferative glomerulonephritis2011

    • Author(s)
      Narita I
    • Organizer
      Symposium of Advancement in Treatment of Nephrotic Syndrome(招待講演)
    • Place of Presentation
      横浜グランドインターコンチネンタルホテル(横浜)
    • Related Report
      2011 Research-status Report
  • [Book] 次世代シークエンサー、Annual Review腎臓2013 (富野康日己、柏原直樹、成田一衛編)2013

    • Author(s)
      後藤 眞、細道一善、成田一衛
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] 膜性増殖性糸球体腎炎I型,III型 新しい診断と治療のABC80/腎8ネフローゼ症候群 2013年 最新医学 別冊2013

    • Author(s)
      金子佳賢、成田一衛 (今井 圓裕 編)
    • Total Pages
      268
    • Publisher
      最新医学社
    • Related Report
      2013 Annual Research Report
  • [Book] Annual Review 腎臓 20132013

    • Author(s)
      後藤眞、細道一善、成田一衛
    • Total Pages
      351
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Book] ネフローゼ症候群 in 今日の治療方針 私はこう治療している2013

    • Author(s)
      成田一衛(山口徹、北原光夫、福井 次矢編)
    • Total Pages
      1978
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] Annual Review腎臓20132013

    • Author(s)
      後藤 眞、成田一衛
    • Total Pages
      349
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] 糖鎖不全IgAに対する新規受容体とIgA腎症発症機序 Annual Review 腎臓2012(富野康日己、柏原直樹、成田一衛編)2012

    • Author(s)
      金子佳賢、成田一衛
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] Annual Review腎臓 20122012

    • Author(s)
      金子佳賢、成田一衛
    • Total Pages
      231
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] 尿細管性アシドーシスとその他の尿細管疾患 今日の治療指針2011(山口 徹、北原 光夫、福井 次矢編)2011

    • Author(s)
      成田一衛
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Book] GWAS Annual Review腎臓2011(富野康日己、柏原直樹、成田一衛編)2011

    • Author(s)
      後藤眞、成田一衛
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] IgA腎症の発症・進展メカニズム-エビデンスに基づいた診断と治療, IgA腎症診療マニュアル改訂第3版 (富野康日己編)2011

    • Author(s)
      後藤眞、成田一衛
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] Annual Review腎臓 20112011

    • Author(s)
      成田一衛, 他
    • Total Pages
      231
    • Publisher
      中外医学社
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi