| Project/Area Number |
23659443
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
MATSUO Seiichi 名古屋大学, 医学系研究科, 教授 (70190410)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Shoichi 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253)
AKIYAMA Shinichi 名古屋大学, 医学(系)研究科(研究院), 特任講師 (20500010)
OZAKI Takenori 名古屋大学, 医学部附属病院, 病院助教 (10452195)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 幹細胞 / 再生医療 / 免疫抑制 / 脂肪由来間葉系幹細胞 / 強皮症 / マクロファージ / メタボローム解析 |
|---|
| Research Abstract |
We have proven that low serum cultured adipose derived mesenchymal stem cells (LASC) suppress T cell proliferation and induce polarization of macrophages into immunomodulatory M2 type, and that these effects of LASC were much stronger than high serum cultured adipose derived mesenchymal stem cells (HASC) or bone marrow derived mesenchymal stem cells (BM-MSC). Inthis study, we studied the mechanisms involved in the immunosuppressive functionof LASC by comparing with HASC or BM-MSC. We found by neutralization experiment and stimulation experiment that LASC derived PGE2 and IL-6 are necessary for the polarization of M2 macrophages, and that PGE2 function via EP4 receptor.
|
