Analysis of inhibitory derivatives for parathyroid gland hormone secretion
| Project/Area Number |
23659444
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Foundation for Biomedical Research and Innovation |
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Principal Investigator |
IMURA AKIHIRO 公益財団法人先端医療振興財団, その他部局等, 研究員 (60362513)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | PTH / Klotho / FGF23 / glucronide / αクロトー / グルクロン酸 / エストロン / デリバティブ / クロトー / 有機合成 / 阻害薬 / 二次性副甲状腺機能亢進症 |
|---|
| Research Abstract |
Over half patients with renal failure suffer hyperparathyroidism(HPT). HPT leads to severe osteoporotic state. Recently, a CaR agonist, cinacalcet has been developed to suppress parathyroid gland. In contrast, aKlotho and FGF23 are both essential for regulating PTH secretion. We addressed the principle that aKlotho contributes to PTH secretion and then surveyed the inhibitory chemicals. Screening study revealed estron glucuronide and its derivatives are candidates for suppression of PTH secretion. These data would be seeds for PTH inhibitory drugs based on aKlotho structure.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism.2014
Author(s)
Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y.
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Journal Title
PLoS One.
Volume: 9(1):e86301
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary Calcium excretion2012
Author(s)
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
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Journal Title
Kidney Int
Volume: 81(6)
Pages: 539-47
Related Report
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[Journal Article] Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion.2012
Author(s)
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y.
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Journal Title
Kidney Int
Volume: 81
Pages: 539-47
Related Report
Peer Reviewed
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[Journal Article] Circulating levels of soluble alpha-Klotho are markedly elevated in human umbilical cord blood2011
Author(s)
Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K
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Journal Title
J CIin Endocrinol Metab
Volume: 96(6)
Related Report
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[Journal Article] circulating levels of soluble a-Klotho are markedly elevated in human umbilical cord blood2011
Author(s)
Ohata Y, Arahori H, Namba N, Kitaoka T, Hirai H, Wada K, Nakayama M, Michigami T, Imura A, Nabeshima Y, Yamazaki Y, Ozono K.
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Journal Title
J clin Endocrinol Metab
Volume: 96
Pages: 943-947
Related Report
Peer Reviewed
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