| Project/Area Number |
23659454
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TODA Tatsushi 神戸大学, 医学研究科, 教授 (30262025)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAGAMORI Shushi 大阪大学, 医学系研究科, 助教 (90467572)
MIYAKE Katsuya 香川大学, 医学部, 准教授 (30219745)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 細胞・組織 / 筋ジストロフィー / 膜修復 / ジスフェルリン / 神経分子病態学 / 細胞膜修復 |
|---|
| Research Abstract |
Anti-dysferlin antibodies and a method to isolate dysferlin-containing vesicle were established, which enables us to analyze components of the dysferlin-containing membranes. Proteins up-regulated correlatively to disease severity of muscular dystrophy were identified. Analyses of double mutant mice of dysferlin and other muscular dystrophy mice showed that dysferlin-deficiency led more severe muscular dystrophic phenotype. These results will contribute to deeper understanding of muscular dystrophy pathogenesis.
|
