Evaluation of new nanotechnology to raise HDL cholesterol level and elucidation of its molecular mechanism
Project/Area Number |
23659463
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Akimitsu 筑波大学, 医学医療系, 准教授 (70344893)
MATSUZAKA Takashi 筑波大学, 医学医療系, 准教授 (70400679)
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Project Period (FY) |
2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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Keywords | リポタンパク質 / 動脈硬化 / 胆汁酸 / ナノテクノロジー / 脂質異常症 |
Research Abstract |
Raising HDL-cholesterol (C) has emerged as a potential strategy to tackle the residual risk that remains even after lowering LDL-C and triglyceride, in preventing cardiovascular disease. PEGylated and quaternized polyamine nanogel (Q-Nanogel) is a newly synthesized bile salt sequestering agent intended to treat dyslipidemia. We assessed the effects of Nanogel on dyslipidemia and atherosclerosis. Nanogel treatment resulted in a 35% reduction in plasma VLDL/LDL-C levels, a 58% increase in plasma HDL-C levels in C57BL/6J mice. In LDLR-/-mice, atherosclerotic lesion size with Nanogel was reduced by 45% compared to PBS. These data indicate that Nanogel not only decreased VLDL/LDL-C levels but also raised HDL-C levels. Nanogel could be a potential therapeutic candidate to raise HDL-C and the treatment of atherosclerosis.
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Report
(2 results)
Research Products
(26 results)
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[Journal Article] TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice2012
Author(s)
Iwasaki H, Naka A, Iida KT, Nakagawa Y, Matsuzaka T, Ishii KA, Kobayashi K, Takahashi A, Yatoh S, Yahagi N, Sone H, Suzuki H, Yamada N, Shimano H.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302(7)
Pages: 896-902
Related Report
Peer Reviewed
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[Journal Article] Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice2011
Author(s)
Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K,Nakagawa Y, Iwasaki H, Kobayashi K, YatohS, Takahashi A, Sone H, Suzuki H, Yahagi N,Yamada N, Shimano H
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31(9)
Pages: 1973-9
Related Report
Peer Reviewed
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[Journal Article] Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Kruppel-like factor 5(KLF5)/peroxisome proliferator-activatedreceptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice2011
Author(s)
Kumadaki S, Karasawa T, Matsuzaka T, EmaM, Nakagawa Y, Nakakuki M, Saito R,Yahagi N, Iwasaki H, Sone H, Takekoshi K,Yatoh S, Kobayashi K, Takahashi A, SuzukiH, Takahashi S, Yamada N, Shimano H
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Journal Title
J Biol Chem
Volume: 286(47)
Pages: 40835-46
Related Report
Peer Reviewed
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[Journal Article] Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.2011
Author(s)
Karasawa T, Takahashi A, Saito R, Sekiya M,Igarashi M, Iwasaki H, Miyahara S,Koyasu S, Nakagawa Y, Ishii K, Matsuzaka T, Kobayashi K, Yahagi N, Takekoshi K, Sone H, Yatoh S, Suzuki H, Yamada N,S himano H
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31(8)
Pages: 1788-95
Related Report
Peer Reviewed
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[Journal Article] Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c)2011
Author(s)
Amemiya-Kudo M, Oka J, Takeuchi Y, Okazaki H, Yamamoto T, Yahagi N, Matsuzaka K, Okazaki S, Osuga J, Yamada N, Murase T, Shimano H
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Journal Title
J Biol Chem
Volume: 286(32)
Pages: 27902-14
Related Report
Peer Reviewed
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