Research Project
Grant-in-Aid for Challenging Exploratory Research
In this study, we demonstrate that adiponectin activates AMPK via AdipoR1 in the hypothalamus, leading to stimulation of food intake and decrease in energy expenditure. We also found that serum and CSF adiponectin levels and expression of AdipoR1 in the ARH increase during fasting and decrease after refeeding, suggesting that adiponectin acts mainly under fasting conditions. Based on these results, we propose that adiponectin serves as a starvation hormone that facilitates efficient fat storage in WAT under fasting conditions.
All 2012 2011
All Journal Article (21 results) (of which Peer Reviewed: 19 results) Presentation (66 results)
Cell
Volume: 148 Pages: 834-834
Endocrinology
Volume: 153 Pages: 1093-1102
Volume: 148 Pages: 624-624
J. Exp. Med.
Volume: 208 Pages: 2403-2416
Biochem. Biophys. Res. Commun.
Volume: 415 Pages: 545-550
Proc. Natl. Acad. Sci. USA.
Volume: 108 Pages: 12072-12077
Cell Metab.
Volume: 13 Pages: 550-561
Volume: 13 Pages: 401-412
Volume: 108 Pages: 5753-5758
Gastroenterology
Volume: 140 Pages: 2000-2008
Metabolism
Volume: 60 Pages: 617-28
Biol. Reprod.
Volume: 84 Pages: 682-688
Proc Natl Acad Sci U S A
Cell Metah
Proc.Natl.Acad Sci.U S A.
Biochem Biophys.Res.Commun.
J.Exp.Med.