Research Project
Grant-in-Aid for Challenging Exploratory Research
We identified mRNA expression of Phosphatidylethanolamine N-methyltransferase (Pemt) was up-regulated in the liver tissue of obese mice. Body weight and accumulation of adipose tissues were prominently reduced in high fat-high sucrose induced obese Pemtknockout mice and insulin resistance was significantly improved. However, these animals developed severe steatohepatitis and ultimately liver cirrhosis and adenomas. The reduction of Pemt activity is involved in the development of non-alcoholic steatohepatitis.
All 2013 2012 2011 Other
All Journal Article (33 results) (of which Peer Reviewed: 33 results) Presentation (6 results) (of which Invited: 2 results) Book (2 results)
BMC Nephrol
Volume: 14 Pages: 23-23
120005324795
Circ Res
Volume: 112(5) Pages: 771-80
Nephron Exp Nephrol
Volume: 121(3-4)
Diab Vasc Dis Res
Volume: 10(1) Pages: 93-6
Volume: 10(1) Issue: 1 Pages: 93-96
10.1177/1479164112444640
Volume: 121(3-4) Issue: 3-4 Pages: 97-108
10.1159/000343102
Cir Res
Volume: 112(5) Issue: 5 Pages: 771-780
10.1161/circresaha.111.300049
Volume: 14 Issue: 1 Pages: 23-23
10.1186/1471-2369-14-23
Volume: 13(1) Pages: 163-163
120005315579
J Am Soc Nephrol
Volume: 23(11) Pages: 1835-46
Diabetes
Volume: 61(11) Pages: 2823-32
120005300245
Int J Nephrol Renovasc Dis
Volume: 5 Pages: 91-6
Hepatology
Volume: 56(3) Pages: 912-21
J Clin Endocrinol Metab
Volume: 97(7)
120005232486
Endocrinology
Volume: 153(2) Pages: 612-20
Diabetologia
Volume: 55(2) Pages: 530-2
J Pathol
Volume: 226(5) Pages: 784-95
130004505771
Volume: 55(2) Issue: 2 Pages: 530-532
10.1007/s00125-011-2385-0
Volume: 153(2) Issue: 2 Pages: 612-620
10.1210/en.2011-1579
Volume: 97(7) Issue: 7 Pages: E1202-E1207
10.1210/jc.2011-3297
Volume: 56(3) Issue: 3 Pages: 912-921
10.1002/hep.25782
Volume: 5 Pages: 91-96
10.2147/ijnrd.s32191
Volume: 61(11) Issue: 11 Pages: 2823-2832
10.2337/db12-0232
Volume: 23(11) Issue: 11 Pages: 1835-1846
10.1681/asn.2012010022
Volume: 13(1) Issue: 1 Pages: 163-163
10.1186/1471-2369-13-163
Volume: 226(5) Issue: 5 Pages: 784-795
10.1002/path.3001
Volume: 55(2) Pages: 530-532
Volume: 51(6) Pages: 619-623
Exp Diabetes Res 2011
Pages: 534872-534872
Clin J Am Soc Nephrol
Volume: 6(6) Pages: 1337-44
Volume: 60(3) Pages: 960-8
Volume: 60(1) Pages: 189-99
Volume: 6(6) Pages: 1337-1344