Regulation of the pancreatic beta-cell proliferation during non-pregnant period
| Project/Area Number |
23659472
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYOFUKU Yukiko 順天堂大学, 医学研究科, 研究員 (70598078)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | エネルギー・糖質代謝異常 / 膵 ss細胞 / セロトニン / 妊娠 / 糖尿病 / 膵β細胞 / 細胞増殖 / 妊娠糖尿病 |
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| Research Abstract |
During pregnancy, the increase of pancreatic beta cell mass is observed to compensate for insulin resistance. In this regard, we reported that increased production of serotonin in pancreatic beta cells elicits the proliferation of pancreatic beta cells (Kim H. et al Nat Med 16:804-808, 2010), however there have been no reports showing the expression of serotonin in pancreatic beta cells in non-pregnant period. Recently, we found the expression of serotonin in pancreatic beta cells in RIP (rat insulin promoter)- Cre mouse generated by Dr. Magnuson’ s group in non-pregnant period. However, we found no serotonin expression in beta cells in another line of RIP-Cre mice generated by Dr. Herrera’ s mice and PDX-1 Cre mice. These results suggest that the change of the expression of the gene located near the integration site of Cre in RIP - Cre mouse generated by Dr. Magnuson’ s group may cause the change of the expression of serotonin.
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Report
(3 results)
Research Products
(6 results)
