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Regulation of the pancreatic beta-cell proliferation during non-pregnant period

Research Project

Project/Area Number 23659472
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionJuntendo University

Principal Investigator

WATADA Hirotaka  順天堂大学, 医学部, 教授 (60343480)

Co-Investigator(Kenkyū-buntansha) TOYOFUKU Yukiko  順天堂大学, 医学研究科, 研究員 (70598078)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsエネルギー・糖質代謝異常 / 膵 ss細胞 / セロトニン / 妊娠 / 糖尿病 / 膵β細胞 / 細胞増殖 / 妊娠糖尿病
Research Abstract

During pregnancy, the increase of pancreatic beta cell mass is observed to compensate for insulin resistance. In this regard, we reported that increased production of serotonin in pancreatic beta cells elicits the proliferation of pancreatic beta cells (Kim H. et al Nat Med 16:804-808, 2010), however there have been no reports showing the expression of serotonin in pancreatic beta cells in non-pregnant period. Recently, we found the expression of serotonin in pancreatic beta cells in RIP (rat insulin promoter)- Cre mouse generated by Dr. Magnuson’ s group in non-pregnant period. However, we found no serotonin expression in beta cells in another line of RIP-Cre mice generated by Dr. Herrera’ s mice and PDX-1 Cre mice. These results suggest that the change of the expression of the gene located near the integration site of Cre in RIP - Cre mouse generated by Dr. Magnuson’ s group may cause the change of the expression of serotonin.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (6 results)

All 2012 2011 Other

All Journal Article (5 results) Remarks (1 results)

  • [Journal Article] 妊娠時の膵ss細胞機能における新知見2012

    • Author(s)
      豊福優希子,内田豊義,綿田裕孝
    • Journal Title

      Daiabetes Frontier

      Volume: 23 Pages: 407-412

    • Related Report
      2012 Final Research Report
  • [Journal Article] 膵ss細胞の分子増殖:妊娠時の膵ss細胞2012

    • Author(s)
      豊福優希子,内田豊義,綿田裕孝
    • Journal Title

      Islet equality

      Volume: 1 Pages: 20-24

    • Related Report
      2012 Final Research Report
  • [Journal Article] 妊娠による膵 ss細胞機能、容積変化のメカニズム2011

    • Author(s)
      豊福優希子,綿田裕孝
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 32 Pages: 197-203

    • Related Report
      2012 Final Research Report
  • [Journal Article] セロトニンによる妊娠時の膵 ss 細胞機能・容積変化のメカニズム2011

    • Author(s)
      綿田裕孝,豊福優希子,内田豊義
    • Journal Title

      実験医学

      Volume: 29 Pages: 1226-1232

    • Related Report
      2012 Final Research Report
  • [Journal Article] 妊娠に伴う膵ss細胞増殖のメカニ ズム2011

    • Author(s)
      綿田裕孝,豊福優希子,内田豊義
    • Journal Title

      Diabetes Journal:糖尿病と代謝

      Volume: 39 Pages: 193-199

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/taisya_naibunpitsu/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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