Research Project
Grant-in-Aid for Challenging Exploratory Research
In BMM of Elovl6 KO, it is promotion of proliferation and differentiation. In addition, activation of the bone resorption function in mature osteoclasts was observed. At this time, there was no change with a typical differentiation marker, but expression of the gene relevant to a cell cycle was increasing. Furthermore, proliferation and differentiation were accelerating also in osteoblasts. Therefore, the composition change of fatty acid affects energy metabolism and a cell cycle, and is considered to adjust proliferation and differentiation.
All 2013 2012 2011 Other
All Journal Article (12 results) (of which Peer Reviewed: 12 results, Acknowledgement Compliant: 1 results, Open Access: 1 results) Presentation (1 results) Book (1 results) Remarks (1 results)
J Bone Miner Res
Volume: 28 Issue: 11 Pages: 2392-2399
10.1002/jbmr.1976
J Pharmacol Sci.
Volume: 121 Pages: 67-73
10031147588
Biochemical and Biophysical Research Communications
Volume: 430 Issue: 2 Pages: 664-669
10.1016/j.bbrc.2012.11.094
American Journal of Physiology-Endocrinology and Metabolism
Volume: 303 Issue: 8 Pages: E1006-E1014
10.1152/ajpendo.00156.2012
Hepatology
Volume: 56 Issue: 6 Pages: 2199-2208
10.1002/hep.25932
Clini Endocrinol.
Volume: 77 Issue: 5 Pages: 707-714
10.1111/j.1365-2265.2012.04421.x
Biochem Biophys Res Commun
Volume: 420 Pages: 931-6
Am J Physiol Endocrinol Metab
Volume: 302(7) Issue: 7 Pages: E896-E902
10.1152/ajpendo.00204.2011
American Journal of Physiology Endocrinology and Metabolism
Volume: 302 Issue: 6 Pages: 615-625
10.1152/ajpendo.00035.2011
Volume: 303 (8)
Arterioscler Thromb Vasc Biol
Volume: 31 Issue: 9 Pages: 1973-9
10.1161/atvbaha.110.221663
Volume: 31 Issue: 8 Pages: 1788-95
10.1161/atvbaha.110.219659
http://www.u-tsukuba-endocrinology.jp/