The regulatory mechanisms of brown adipose tissue by novel adipokine chemerin

• Project/Area Number: 23659477
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Kobe University
• Principal Investigator: TAKAHASHI Yutaka 神戸大学, 医学(系)研究科(研究院), 講師 (70301281)
• Co-Investigator(Kenkyū-buntansha): IGUCHI Genzo 神戸大学医学部附属病院, 糖尿病内分泌内科, 助教 (60346260) ; FUKUOKA Hidenori 神戸大学医学部附属病院, 糖尿病内分泌内科, 助教 (80622068)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ケマリン / アディポカイン

Research Abstract

We previously identified chemerin as a novel adipokine that regulates glucose homeostasis (FEBS letters 2008). We have reported that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose production and impaired insulin secretion. Expression of MafA, a pivotal transcriptional factor for beta-cell function, was downregulated and rescue of MafA expression restored GSIS, indicating that chemerin regulates beta-cell function via maintaining MafA expression (Scientific Reports 2011). We further demonstrated that serum chemerin concentrations are decreased in patients with T2DM (EJ 2013). In addition, we have clarified a novel regulatory pathway of BAT function in adaptive thermogensis by chemerin.

Research Products

• [Journal Article] Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome (2014)
  • Author(s): Bando H, Iguchi G, Fukuoka H, Yamamoto M, Matsumoto R, Hidaka-Takeno R, Okimura Y, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Toji K, Takahashi Y
  • Journal Title: J Clin Endocrinol Metab Volume: (in press)
  • Peer Reviewed
• [Journal Article] The prevalence and associated factors of colorectal neoplasms in 1 acromegaly : a single center based study (2014)
  • Author(s): Yamamoto M, Fukuoka H, Iguchi G, Matsumoto R, Takahashi M, Nishizawa H, Suda K, Bando H, Takahashi Y
  • Journal Title: Pituitary Volume: (in press)
  • Peer Reviewed
• [Journal Article] A missense single-nucleotide polymorphism in the sialic acid acetyl esterase gene is associated with anti-PIT-1 antibody syndrome (2014)
  • Author(s): Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y
  • Journal Title: Endocrine J Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma (2013)
  • Author(s): Nishizawa H, Fukuoka H, Iguchi G, Inoshita N, Yamada S, Takahashi Y
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes Volume: 121 Pages: 295-9
  • Peer Reviewed
• [Journal Article] Decreased serum chemerin levels in male Japanese patients with type 2 diabetes : sex dimorphism (2013)
  • Author(s): Takahashi M, Inomata S, Okimura Y, Iguchi G, Fukuoka H, Miyake K, Koga D, Akamatsu S, Kasuga M, Takahashi Y
  • Journal Title: Endocrine J Volume: 60 Pages: 37-44
  • NAID: 10031156720
  • Peer Reviewed
• [Journal Article] A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression (2013)
  • Author(s): Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
  • Journal Title: Mol Cell Endocrinol Volume: 376 Pages: 93-8
  • Peer Reviewed
• [Journal Article] Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly : a retrospective clinical study and review of the literature (2013)
  • Author(s): Suda K, Inoshita N, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Yamamoto M, Yamada S, Takahashi Y
  • Journal Title: Endocrine J Volume: 60 Pages: 507-515
  • NAID: 10031170640
  • Peer Reviewed
• [Journal Article] SIRT1 regulates adaptive response of growth hormone-insulin-like growth factor-I axis under fasting conditions in the liver (2013)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Suda K, Bando H, Takahashi M, Nishizawa H, Seino S, Takahashi Y
  • Journal Title: Proc Natl Acad Sci USA Volume: 110 Pages: 14948-53
  • Peer Reviewed
• [Journal Article] The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature (2013)
  • Author(s): Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y
  • Journal Title: Eur J Endocrinol Volume: 170 Pages: 161-72
  • Peer Reviewed
• [Journal Article] 家族性先端巨大症 知っておきたい先天性・遺伝性内分泌疾患 (2013)
  • Author(s): 高橋 裕
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 37巻 Pages: 399-403
• [Journal Article] The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature. (2013)
  • Author(s): Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y.
  • Journal Title: Eur J Endocrinol. Volume: 170 Issue: 2 Pages: 161-172
  • DOI: 10.1530/eje-13-0642
  • Peer Reviewed
• [Journal Article] SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver. (2013)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Suda K, Bando H, Takahashi M, Nishizawa H, Seino S, Takahashi Y.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 110 Issue: 37 Pages: 14948-14953
  • DOI: 10.1073/pnas.1220606110
  • Peer Reviewed
• [Journal Article] Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature. (2013)
  • Author(s): Suda K, Inoshita N, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Yamamoto M, Yamada S, Takahashi Y.
  • Journal Title: Endocrine J. Volume: 60 Pages: 507-515
  • NAID: 10031170640
  • Peer Reviewed
• [Journal Article] A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression. (2013)
  • Author(s): Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y.
  • Journal Title: Mol Cell Endocrinol. Volume: 376 Issue: 1-2 Pages: 93-98
  • DOI: 10.1016/j.mce.2013.05.022
  • Peer Reviewed
• [Journal Article] Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism. (2013)
  • Author(s): Takahashi M, Inomata S, Okimura Y, Iguchi G, Fukuoka H, Miyake K, Koga D, Akamatsu S, Kasuga M, Takahashi
  • Journal Title: Endocrine J. Volume: 60 Pages: 37-44
  • NAID: 10031156720
  • Peer Reviewed
• [Journal Article] AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. (2013)
  • Author(s): Nishizawa H, Fukuoka H, Iguchi G, Inoshita N, Yamada S, Takahashi Y.
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes. Volume: 121 Issue: 05 Pages: 295-9
  • DOI: 10.1055/s-0032-1331697
  • Peer Reviewed
• [Journal Article] Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature. (2013)
  • Author(s): Suda K, Inoshita N, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Yamamoto M, Yamada S, Takahashi Y
  • Journal Title: Endocrine J Volume: 60 Pages: 507-515
  • NAID: 10031170640
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Taniguchi M, Nishihara M, Sasayama T, Takahashi Y, Kohmura E
  • Journal Title: Neuropathol Appl Neurobiol Volume: 39(4) Issue: 4 Pages: 445-8
  • DOI: 10.1111/nan.12000
  • Peer Reviewed
• [Journal Article] Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats (2012)
  • Author(s): Maki T, Yamamoto D, Nakanishi S, Iida K, Iguchi G, Takahashi Y, Kaji H, Chihara K, Okimura Y
  • Journal Title: Nutr Res Volume: 32 Pages: 676-83
  • Peer Reviewed
• [Journal Article] A rapidly expanding immature teratoma originating from a neurohypophyseal germinoma (2012)
  • Author(s): Taniguchi M, Nishihara M, SasayamaT, Takahashi Y, Kohmura E
  • Journal Title: Neuropathology and Applied Neurobiology Volume: 39 Pages: 445-8
  • Peer Reviewed
• [Journal Article] IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway (2012)
  • Author(s): Handayaningshi AE, Takahashi M, Fukuoka H, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Takahashi Y
  • Journal Title: Biochem Biophys Res Commun Volume: 425 Pages: 478-84
  • Peer Reviewed
• [Journal Article] A case of type A insulin resistance associated with heterozygous Asn462Ser mutation of the insulin receptor gene (2012)
  • Author(s): Hashimoto N, Yokoi N, Komada H, Matsuda T, Hirota Y, Sakaguchi K, Takahashi Y, Ogawa W, Seino S
  • Journal Title: Diabetology Internastional Volume: 3 Pages: 239-243
  • NAID: 10030590214
  • Peer Reviewed
• [Journal Article] GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model (2012)
  • Author(s): Nishizawa H, Takahashi M, Fukuoka H, Iguchi G, Kitazawa R, Takahashi Y
  • Journal Title: Biochem Biophys Res Commun Volume: 423 Pages: 295-300
  • Peer Reviewed
• [Journal Article] Nonalcoholic fatty liver disease in adult hypopituitary patient with growth hormone deficiency and the impact of growth hormone replacement therapy (2012)
  • Author(s): Nishizawa H, Iguchi G, Murawaki A, Fukuoka H, Hayashi H, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y
  • Journal Title: Eur J Endocrinol Volume: 167 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Growth hormone deficiency in two siblings associated with combined GH1 gene polymorphisms (2012)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Miyako K, Takahashi Y
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes Volume: 120 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans (2012)
  • Author(s): Nishizawa S, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Fumihiko H, Yamanouchi K, Nishihara M, Seino S, Takahashi SI, Takahashi Y
  • Journal Title: Growth Hormone and IGF-I Research Volume: 22 Pages: 64-68
  • Peer Reviewed
• [Journal Article] Essential roles of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the liver (2012)
  • Author(s): Takahashi Y
  • Journal Title: Endcrine J Volume: 59 Pages: 955-962
  • NAID: 10031146704
• [Journal Article] The regulation of aging and cellular senescence by IGF-I (2012)
  • Author(s): Takahashi Y
  • Journal Title: Anti-Aging Medicine Volume: 9 Pages: 174-179
• [Journal Article] Science of nonalcoholic fatty liver disease in Anti-Aging Medicine (2012)
  • Author(s): Sumida Y, Naito Y, Hashimoto E, Aoi W, Takahashi Y, Yonei Y, Yoshikawa T
  • Journal Title: Anti-Aging Medicine Volume: 9 Pages: 24-33
• [Journal Article] 高橋 裕小児内分泌疾患のトランジション(総説) (2012)
  • Author(s): 高橋 裕
  • Journal Title: 小児科診療 Volume: 75巻 Pages: 477-482
• [Journal Article] 症例に学ぶNASH/NAFLDの診断と治療 : 成人成長ホルモン分泌不全症にNASH が合併し成長ホルモンが著効した症例 (2012)
  • Author(s): 高橋 裕
  • Journal Title: 診断と治療 Volume: 別冊 Pages: 171-174
• [Journal Article] 自己抗体研究の新展開 : 内分泌領域の自己抗体研究の進歩(総説) (2012)
  • Author(s): 高橋 裕
  • Journal Title: 臨床化学 Volume: 41巻 Pages: 5-8
• [Journal Article] 内分泌疾患-疑うヒントと専門医へ紹介するポイント-先端巨大症(総説) (2012)
  • Author(s): 高橋 裕
  • Journal Title: 診断と治療 Volume: 100巻 Pages: 1103-1107
• [Journal Article] 知っておきたい内科症候群、抗PIT-1 抗体症候群(総説) (2012)
  • Author(s): 高橋 裕、井口元三
  • Journal Title: 内科 Volume: 6巻 Pages: 1333-1334
• [Journal Article] 新たな疾患概念「抗PIT-1 抗体症候群」 (2012)
  • Author(s): 高橋 裕、山本雅昭、井口元三
  • Journal Title: バイオクリニカ Volume: 27巻 Pages: 87-90
• [Journal Article] 小児期から成人期へ : GH 分泌不全症の移行期診療を考える (2012)
  • Author(s): 島津章、香川二郎、都研一、高橋裕、堀川玲子、高野幸路、中村明枝、沼倉周彦、北中幸子、長崎啓祐、河野斉、西美和
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 35巻 Pages: 275-283
• [Journal Article] 成人GH 分泌不全症 (2012)
  • Author(s): 高橋 裕
  • Journal Title: からだの科学 Volume: 275巻 Pages: 27-30
• [Journal Article] AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. (2012)
  • Author(s): Nishizawa H, Fukuoka H, Iguchi G, Inoshita N, Yamada S, Takahashi Y.
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes Volume: 120 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats. (2012)
  • Author(s): Maki T, Yamamoto D, Nakanishi S, Iida K, Iguchi G, Takahashi Y, Kaji H, Chihara K, Okimura Y.
  • Journal Title: Nutr Res Volume: 32 Pages: 676-83
  • Peer Reviewed
• [Journal Article] IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway. (2012)
  • Author(s): Handayaningshi AE, Takahashi M, Fukuoka H, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Takahashi Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 425 Pages: 478-84
  • Peer Reviewed
• [Journal Article] Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism. (2012)
  • Author(s): Takahashi M, Inomata S, Okimura Y, Iguchi G, Fukuoka H, Miyake K, Koga D, Akamatsu S, Kasuga M, Takahashi Y.
  • Journal Title: Endocrine J Volume: 60 Pages: 37-44
  • NAID: 10031156720
  • Peer Reviewed
• [Journal Article] GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model. (2012)
  • Author(s): Nishizawa H, Takahashi M, Fukuoka H, Iguchi G, Kitazawa R, Takahashi Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 423 Pages: 295-300
  • Peer Reviewed
• [Journal Article] Nonalcoholic fatty liver disease in adult hypopituitary patient with growth hormone deficiency and the impact of growth hormone replacement therapy. (2012)
  • Author(s): Nishizawa H, Iguchi G, Murawaki A, Fukuoka H, Hayashi H, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y.
  • Journal Title: Eur J Endocrinol Volume: 167 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Growth hormone deficiency in two siblings associated with combined GH1 gene polymorphisms. (2012)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Miyako K, Takahashi Y.
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes Volume: 120 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans. (2012)
  • Author(s): Nishizawa S, Handayanings ih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Fumihiko H, Yamanouchi K, Nishihara M, Seino S, Takahashi SI, Takahashi Y.
  • Journal Title: Growth Hormone and IGF-I Research Volume: 22 Pages: 64-68
  • Peer Reviewed
• [Journal Article] Chemerin regulates β-cell function in mice. (2011)
  • Author(s): Takahashi M, Okimura Y, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Kitazawa R, Fujimoto W, Takahashi K, Zolotaryov FN, Hong KS, Kiyonari H, Abe T, Kaji H, Kitazawa S, Kasuga M, Chihara K, Takahashi Y.
  • Journal Title: Scientific Reports Volume: 1 Issue: 1 Pages: 123-123
  • DOI: 10.1038/srep00123
  • Peer Reviewed
• [Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes (2011)
  • Author(s): Handayaningshi AE, Iguchi G, Fukuoka H, Nishizawa H, Takahashi M, Yamamoto M, Herningtyas HE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Journal Title: Endocrinology Volume: 152 Pages: 912-21
  • Peer Reviewed
• [Journal Article] A case of primary aldosteronism caused by multiple adrenocortical macronodules (2011)
  • Author(s): Hashimoto N, Kawamura Y, Nakamura T, Murawaki A, Nishiumi T, Hirota Y, Sakagushi K, Kurahashi T, Miyake H, Fujisawa M, Sasano H, Takahashi Y
  • Journal Title: Intern Med Volume: 50 Pages: 585-90
  • NAID: 130000649890
  • Peer Reviewed
• [Journal Article] Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody in humans (2011)
  • Author(s): Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano S, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo T, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y
  • Journal Title: J Clin Invest Volume: 121 Pages: 113-9
  • NAID: 120004754212
  • Peer Reviewed
• [Journal Article] CKD と成長ホルモン(総説) (2011)
  • Author(s): 高橋 裕
  • Journal Title: ホ ルモンと臨床 Volume: 58巻 Pages: 1-4
• [Journal Article] 視床下部腫瘍(総説) (2011)
  • Author(s): 高橋 裕
  • Journal Title: 日本臨床 増刊号 Volume: 69巻 Pages: 142-145
• [Journal Article] 成人GH 分泌不全症の成人期管理(総説) (2011)
  • Author(s): 高橋 裕
  • Journal Title: ホルモンと臨床 Volume: 58巻 Pages: 41-45
• [Journal Article] 抗 PIT-1抗体症候群(総説) (2011)
  • Author(s): 井口元三、山本雅昭、高橋 裕
  • Journal Title: 内分泌・糖尿病科 Volume: 33巻 Pages: 240-246
• [Journal Article] Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody in humans. (2011)
  • Author(s): Yamamoto M et al.
  • Journal Title: J Clin Invest Volume: 121 Issue: 1 Pages: 113-9
  • DOI: 10.1172/jci44073
  • Peer Reviewed
• [Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes. (2011)
  • Author(s): Handayaningshi AE et al.
  • Journal Title: Endocrinology Volume: 152 Issue: 3 Pages: 912-21
  • DOI: 10.1210/en.2010-0981
  • Peer Reviewed
• [Presentation] 小児キャンサーサバイバーにおける内分泌代謝異常とその管理の重要性～健やかな人生のために～ (2013)
  • Author(s): 高橋 裕
  • Organizer: 第55回日本小児血液・がん学会学術集会、第11回日本小児がん看護学会、第18回がんの子どもを守る会公開シンポジウム
  • Place of Presentation: ヒルトン福岡シーホーク
  • Year and Date: 2013-12-01
• [Presentation] 内分泌機能検査のパールとピットフォール(シンポジウム : とことん神経内分泌) (2013)
  • Author(s): 高橋 裕
  • Organizer: 第40回日本神経内分泌学会学術総会
  • Place of Presentation: 宮崎市民プラザ
  • Year and Date: 2013-10-25
• [Presentation] 非アルコール性脂肪性肝炎の新たなメカニズム-成長ホルモン、IGF-I の役割- (2013)
  • Author(s): 高橋 裕
  • Organizer: 第11回大連合大会(第35回日本臨床栄養学会総会、第34回日本臨床栄養協会総会)
  • Place of Presentation: 京都テルサ
  • Year and Date: 2013-10-06
• [Presentation] Novel mechanism leading to hypopituitarism (2013)
  • Author(s): Takahashi Y
  • Organizer: The 9^<th> Joint Meeting of Pediatric Endocrinology, ESPE, PES, APEG, ASPAE, JSPE, SLEP
  • Place of Presentation: Milan
  • Year and Date: 2013-09-21
  • Invited
• [Presentation] The role of primary medical therapy and combined therapy in acromegaly (2013)
  • Author(s): Takahashi Y
  • Organizer: The 2nd Pituitary Expert Meeting in Asia
  • Place of Presentation: Soul
  • Year and Date: 2013-08-31
• [Presentation] High serum cortisol levels at mid-night and after LDDST are associated with elevated levels of D-dimer in patients with Cushing's syndrome (2013)
  • Author(s): Fukuoka H, Takaeuchi T, Iguchi G, Hirota Y, Takahashi Y
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisco
  • Year and Date: 2013-06-15
• [Presentation] The pathophysiological analysis of novel 'anti-PIT-1 antibody syndrome' (2013)
  • Author(s): Iguchi G, Bando H, Yamamoto M, Takeno R, Suda K, Takahashi M, Nishizawa H, Fukuoka H, Takahashi Y
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisco
  • Year and Date: 2013-06-15
• [Presentation] Pathophysiology of IgG4-related hypophysitis : an analysis of 7 patients (2013)
  • Author(s): Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisco
  • Year and Date: 2013-06-15
• [Presentation] SIRT1 regulates adaptive response of GH-IGF-I axis under fasting conditions in the liver (2013)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Suda K, Bando H, Takahashi M, Nishizawa H, Takahashi Y
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisco
  • Year and Date: 2013-06-15
• [Presentation] IGF-I prevents the progression of hepatic fibrosis in nonalcoholic steatohepatitis by inactivating hepatic stellate cells in a p53 dependent manner (2013)
  • Author(s): Nishizawa H, Iguchi G, Fukuoka H, Takahashi M, Yamamoto M, Suda K, Bando H, Takahashi Y
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisco
  • Year and Date: 2013-06-15
• [Presentation] 先端巨大症の新たな病態と治療戦略 (2013)
  • Author(s): 高橋 裕
  • Organizer: Masterclass on Acromegaly
  • Place of Presentation: 東京都市センターホテル
  • Year and Date: 2013-06-01
• [Presentation] 先端巨大症の新たな病態と治療戦略 (2013)
  • Author(s): 高橋 裕
  • Organizer: 第86回日本内分泌学会学術総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2013-04-26
• [Presentation] サブクリニカル機能性下垂体腺腫の病態 (2013)
  • Author(s): 高橋 裕
  • Organizer: 第23回日本間脳下垂体腫瘍学会
  • Place of Presentation: 鹿児島県民センター
  • Year and Date: 2013-03-16
• [Presentation] High serum cortisol levels at mid-night and after LDDST are associated with elevated levels of D-dimer in patients with Cushing’s syndrome. (2013)
  • Author(s): Fukuoka H, Takaeuchi T, Iguchi G, Hirota Y, Takahashi Y.
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisico
• [Presentation] The pathophysiological analysis of novel ‘anti-PIT-1 antibody syndrome’. (2013)
  • Author(s): Iguchi G, Bando H, Yamamoto M, Takeno R, Suda K, Takahashi M, Nishizawa H, Fukuoka H, Takahashi Y.
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisico
• [Presentation] Pathophysiology of IgG4-related hypophysitis: an analysis of 7 patients. (2013)
  • Author(s): Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y.
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisico
• [Presentation] IGF-I prevents the progression of hepatic fibrosis in nonalcoholic steatohepatitis by inactivating hepatic stellate cells in a p53 dependent manner. (2013)
  • Author(s): Nishizawa H, Iguchi G, Fukuoka H, Takahashi M, Yamamoto M, Suda K, Bando H, Takahashi Y.
  • Organizer: The 95th Annual Meeting of the Endocrine Society
  • Place of Presentation: San Francisico
• [Presentation] The role of primary medical therapy and combined therapy in acromegaly. (2013)
  • Author(s): Takahashi Y.
  • Organizer: The 2nd Pituitary Expert Meeting in Asia
  • Place of Presentation: Soul
  • Invited
• [Presentation] Novel mechanism leading to hypopituitarism. (2013)
  • Author(s): Takahashi Y.
  • Organizer: The 9th Joint Meeting of Pediatric Endocrinology
  • Place of Presentation: Milan
  • Invited
• [Presentation] サブクリニカル機能性下垂体腺腫の病態 (2013)
  • Author(s): 高橋 裕
  • Organizer: 第23回日本間脳下垂体腫瘍学会
  • Place of Presentation: 鹿児島 県民交流センター
  • Invited
• [Presentation] 診断治療に難渋した症例、下垂体1（コメンテーター） (2013)
  • Author(s): 高橋 裕
  • Organizer: 第22回臨床内分泌代謝Update
  • Place of Presentation: 大宮ソニックシティ
  • Invited
• [Presentation] 抗 PIT-1 抗体症候群-その後の展開 (2012)
  • Author(s): 高橋 裕、坂東弘教、山本雅昭、井口元三
  • Organizer: 第39回日本神経内分泌学会学術集会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2012-09-29
• [Presentation] A novel missense mutation of AIP gene in a patient with octreotide-resistant non-familial gigantism (2012)
  • Author(s): Fukuoka H, Iguchi G, Suda K, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Yamada S, Takahashi Y
  • Organizer: The 94th Annual Meeting of the Endocrine Society
  • Place of Presentation: Houston
  • Year and Date: 2012-06-23
• [Presentation] SOCS2 missense mutation identified in producing pituitary tumor (2012)
  • Author(s): Suda K, Iguchi G, Fukuoka H, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Takahashi Y
  • Organizer: The 6^<th> international congress of the GRS and the IGF society
  • Place of Presentation: Houston
  • Year and Date: 2012-06-23
• [Presentation] IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cells (2012)
  • Author(s): Nishizawa H, Iguchi G, Fukuoka H, Suda K, Yamamoto M, Takahashi M, Seino S, Takahashi Y
  • Organizer: The 6^<th> international congress of the GRS and the IGF society
  • Place of Presentation: Houston
  • Year and Date: 2012-06-23
• [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone via deacetylation of Stat5 in liver (2012)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Suda K, Seino S, Takahashi Y
  • Organizer: The 6^<th> international congress of the GRS and the IGF society
  • Place of Presentation: Houston
  • Year and Date: 2012-06-23
• [Presentation] インスリン様増殖因子(IGF-I)による寿命制御機構の解明-IGF-I は酸化ストレスを介して細胞老化を促進する- (2012)
  • Author(s): 高橋 裕
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: パシフィコ横浜会議場
  • Year and Date: 2012-06-23
• [Presentation] 生命を育む下垂体ホルモン (2012)
  • Author(s): 高橋 裕
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-04-20
• [Presentation] 成長ホルモン、IGF-I の肝臓における新たな作用と治療応用 (2012)
  • Author(s): 高橋 裕
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-04-19
• [Presentation] 成長ホルモン、IGF-Iの肝臓における新たな作用と治療応用 (2012)
  • Author(s): 高橋 裕
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Invited
• [Presentation] インスリン様増殖因子(IGF-I)による寿命制御機構の解明-IGF-Iは酸化ストレスを介して細胞老化を促進する-(研究奨励賞受賞講演) (2012)
  • Author(s): 高橋 裕
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜国際会議場
  • Invited
• [Presentation] The essential role of GH/IGF-I in liver. (plenary lecture) (2012)
  • Author(s): Yutaka Takahashi
  • Organizer: The 5th international congress of the GRS and the IGF society
  • Place of Presentation: Gasteig, Munich
  • Invited
• [Presentation] A novel missense mutation of AIP gene in a patient with octreotide-resistant non-familial gigantism. (2012)
  • Author(s): Fukuoka H, Iguchi G, Suda K, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Yamada S, Takahashi Y.
  • Organizer: The 94th Annual Meeting of the Endocrine Society
  • Place of Presentation: Houston convention center
• [Presentation] SOCS2 missense mutation identified in a patient with gigantism without GH producing pituitary tumor. (2012)
  • Author(s): Suda K, Iguchi G, Fukuoka H, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Takahashi Y.
  • Organizer: The 94th Annual Meeting of the Endocrine Society
  • Place of Presentation: Houston convention center
• [Presentation] IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cells. (2012)
  • Author(s): Nishizawa H, Iguchi G, Fukuoka H, Suda K, Yamamoto M, Takahashi M, Seino S, Takahashi Y.
  • Organizer: The 94th Annual Meeting of the Endocrine Society
  • Place of Presentation: Houston convention center
• [Presentation] GH and IGF-I ameliorate liver steatosis and fibrosis in nonalcoholic steatohepatitis mouse model (2011)
  • Author(s): Nishizawa H, Iguchi G, Takahashi M, Yamamoto M, Suda S, Okimura Y, Kaji K, Chihara K, Takahashi Y
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston
  • Year and Date: 2011-06-04
• [Presentation] A case of gigantism associated with a missense mutation in SOCS2 gene (2011)
  • Author(s): Suda K, Iguchi G, Yamamoto M, Handayaningsih AE, Nishizawa H, Takahashi M, Okimura Y, Kaji K, Chihara K, Takahashi Y
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston
  • Year and Date: 2011-06-04
• [Presentation] Novel autoimmune polyendocrine syndrome : Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody (2011)
  • Author(s): Takahashi Y, Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano T, Takahashi M, Nishizawa H, Handayaningsih AE, Tojo K, Mokubo A, Iida K, Kaji K, Chihara K
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston
  • Year and Date: 2011-06-04
• [Presentation] 寿命、代謝を制御する成長ホルモン/IGF-I とNAFLD/NASH の密接な関係 (2011)
  • Author(s): 高橋 裕
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-05-29
• [Presentation] 成人GHD の合併症としてのNAFLD/NASH-臨床的意義、メカニズムと臨床応用 (2011)
  • Author(s): 高橋 裕
  • Organizer: 第84回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2011-04-22
• [Presentation] 成人GH 分泌不全症をきたす新たな疾患概念 -後天性GH,PRL,TSH 欠損症- (2011)
  • Author(s): 高橋 裕
  • Organizer: 第20回臨床内分泌代謝 Update
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2011-01-28
• [Presentation] 成人GHD の合併症としてのNAFLD/NASH-トランジションに関する問題点 (2011)
  • Author(s): 高橋 裕
  • Organizer: 第20回臨床内分泌代謝 Update
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2011-01-28
• [Presentation] 新しい下垂体の病気の発見とその意義 (2011)
  • Author(s): 高橋 裕
  • Organizer: 間脳下垂体機能障害に関する調査研究(難治性疾患克服研究事業班会議)
  • Place of Presentation: 名古屋大学医学部
• [Book] 医学大事典 成人成長ホルモン分泌不全症 (2014)
  • Author(s): 高橋 裕
  • Publisher: 南江堂 (in press)
• [Book] 医学大事典 成長ホルモン単独欠損症 (2014)
  • Author(s): 高橋 裕
  • Publisher: 南江堂 (in press)
• [Book] 医学大事典 下垂体前葉ホルモン単独欠損症 (2014)
  • Author(s): 高橋 裕
  • Publisher: 南江堂 (in press)
• [Book] 医学大事典 ラローン型低身長症 (2014)
  • Author(s): 高橋裕
  • Publisher: 南江堂 (in press)
• [Book] 最新肥満症学 新規のアディポサイトカイン ケマリン, 日本臨床 (72巻増刊号) (2014)
  • Author(s): 高橋 裕、高橋路子
• [Book] 下垂体前葉機能低下症 内科外来基本処方Navi (2014)
  • Author(s): 井口元三、高橋 裕
  • Publisher: 中外医学社 (in press)
• [Book] プロラクチノーマ内科外来基本処方Navi (2014)
  • Author(s): 福岡秀規、高橋 裕
  • Publisher: 中外医学社 (in press)
• [Book] 先端巨大症 内科外来基本処方Navi (2014)
  • Author(s): 高橋 裕
  • Publisher: 中外医学社 (in press)
• [Book] 下垂体性巨人症と先端巨大症 今日の小児治療指針 (2014)
  • Author(s): 高橋 裕
  • Publisher: (in press)
• [Book] 先端巨大症の診断基準のポイントは?内分泌代謝クリニカルクエスチョン (2014)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社 (in press)
• [Book] 先端巨大症の薬物療法を具体的に教えてください 内分泌代謝クリニカルクエスチョン (2014)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社 (in press)
• [Book] クッシング病と偽性、異所性ACTH 症候群の鑑別診断法は? 内分泌代謝クリニカルクエスチョン (2014)
  • Author(s): 福岡秀規、高橋 裕
  • Publisher: 診断と治療社 (in press)
• [Book] 高プロラクチン血症の鑑別診断法は? 内分泌代謝クリニカルクエスチョン (2014)
  • Author(s): 福岡秀規、高橋 裕
  • Publisher: 診断と治療社 (in press)
• [Book] リンパ球性下垂体炎の病型と治療は? 内分泌代謝クリニカルクエスチョン (2014)
  • Author(s): 井口元三、高橋 裕
  • Publisher: 診断と治療社 (in press)
• [Book] 成人成長ホルモン分泌不全症の診断と治療は? 内分泌代謝クリニカルクエスチョン (2014)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社 (in press)
• [Book] 糖尿病代謝疾患の分子標的と治療薬事典 D2 ドーパミン受容体作動薬 (2013)
  • Author(s): 高橋裕
  • Publisher: 羊土社
• [Book] アクロメガリーハンドブック、アクロメガリーの病態とGH, IGF-I 過剰 (2013)
  • Author(s): 高橋裕
  • Publisher: メディカルレビュー社
• [Book] 今日の臨床サポート 先端巨大症 (2013)
  • Author(s): 高橋 裕
  • Publisher: エルゼビア・ジャパン
  • URL: http://clinicalsup.jp/jpoc/
• [Book] 糖尿病代謝疾患の分子標的と治療薬事典 D2ドーパミン受容体作動薬 (2013)
  • Author(s): 高橋 裕
  • Total Pages: 332
  • Publisher: 羊土社
• [Book] アクロメガリーハンドブック、アクロメガリーの病態とGH, IGF-I過剰 (2013)
  • Author(s): 高橋 裕
  • Total Pages: 45
  • Publisher: メディカルレビュー社
• [Book] 代謝・内分泌疾患診療最新ガイドライン成人GH 分泌不全症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 総合医学社
• [Book] 下垂体診療マニュアル 成長ホルモン (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 先端巨大症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 成人GH 分泌不全症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル ドーパミンアゴニストと心臓弁膜症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 抗PIT-1 抗体症候群 (2012)
  • Author(s): 井口元三、高橋 裕
  • Total Pages: 185
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 下垂体の転写因子 (2012)
  • Author(s): 井口元三、高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 下垂体茎断裂症候群 (2012)
  • Author(s): 井口元三、高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 特定疾患治療研究事業の対象7疾患の概略 (2012)
  • Author(s): 高橋 裕
  • Total Pages: 41
  • Publisher: 診断と治療社
• [Book] 症例に学ぶNASH/NAFLD の診断と治療 : 成人成長ホルモン分泌不全症にNASH が合併し成長ホルモンが著効した症例 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 内分泌代謝専門医ガイドブック 成長ホルモン分泌不全性低身長症 (2012)
  • Author(s): 高橋裕
  • Publisher: 診断と治療社
• [Book] 内分泌代謝専門医ガイドブック 特定疾患の現状 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 成長ホルモン (2012)
  • Author(s): 高橋 裕
  • Total Pages: 274
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 先端巨大症 (2012)
  • Author(s): 高橋 裕
  • Total Pages: 274
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 成人GH分泌不全症 (2012)
  • Author(s): 高橋 裕
  • Total Pages: 274
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル ドーパミンアゴニストと心臓弁膜症 (2012)
  • Author(s): 高橋 裕
  • Total Pages: 274
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 抗PIT-1抗体症候群 (2012)
  • Author(s): 井口元三、高橋 裕
  • Total Pages: 274
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 下垂体の転写因子 (2012)
  • Author(s): 井口元三、高橋 裕
  • Total Pages: 274
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 下垂体茎断裂症候群 (2012)
  • Author(s): 井口元三、高橋 裕
  • Total Pages: 274
  • Publisher: 診断と治療社
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/im2/doctor/activity/acti-04.html
• [Remarks] 神経内分泌研究グループ
  • URL: http://www.med.kobe-u.ac.jp/im2/doctor/activity/acti-04.html
• [Remarks] 神戸大学大学院医学研究科糖尿病内分泌内科学 神経内分泌グループ
  • URL: http://www.med.kobe-u.ac.jp/im2/doctor/activity/acti-04.html
• [Patent(Industrial Property Rights)] 糖尿病治療剤 (2009)
  • Inventor(s): 高橋裕、千原和夫
  • Industrial Property Rights Holder: 神戸大学、日本ケミカルリサーチ
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2009-05-07
  • Overseas
• [Patent(Industrial Property Rights)] 糖尿病の診断方法 (2009)
  • Inventor(s): 高橋裕、千原和夫、古賀大輔
  • Industrial Property Rights Holder: 神戸大学、大塚製薬
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2009-07-23
  • Overseas