| Project/Area Number |
23659481
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | 公共財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2011) |
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Principal Investigator |
HARA Takahiko 公共財団法人東京都医学総合研究所, 生体分子先端研究分野, 副参事研究員 (80280949)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 内分泌学 / CXCL14 / ケモカイン / CXCR4 / 粘膜組織 / 摂食行動 |
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| Research Abstract |
In order to understand the role of CXCL14, I attempted to identify CXCL14 receptor molecules. As a result of GPCR knockdown experiments and cDNA rescue experiments using THP-1 cell line, I found that CXCL14 binds to CXCR4 with high affinity, and that another orphan GPCR (GPR14) was indispensable for the CXCL14-mediated signal transduction. CXCL14 cross-inhibited the chemotactic activity of CXCL12. GPR14- was abundantly expressed in mucosal tissues along with CXCL14. Therefore, GPR-14-interacting molecules could involved in the feeding behavior control by CXCL14.
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