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Screening of low molecular compounds, which inhibit cell proliferation and survival

Research Project

Project/Area Number 23659488
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionOsaka University

Principal Investigator

KANAKURA Yuzuru  大阪大学, 医学系研究科, 教授 (20177489)

Co-Investigator(Kenkyū-buntansha) ORITANI Kenji  大阪大学, 医学系研究科, 准教授 (70324762)
SAITOH Norimitsu  大阪大学, 医学系研究科, 特任助教(常勤) (30597399)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords低分子化合物 / 増殖 / 細胞周期 / 細胞株 / 細胞増殖 / アポトーシス / スクリーニング / 増殖抑制
Research Abstract

We tried to establish a new anti-proliferative drug through a following process: (1) screening of compounds to inhibit Baf3 cell growth (2) identification of target molecules for the selected compounds (3) analysis of physical effects of each possible compound. We screened approximately 10,000 low molecular compounds, which were provided from Tokyo University, and successfully isolated 61 compounds. Some inhibited Baf3 cell growth, or induced apoptosis, and the others induced morphological changes. Among them, we selected 4 compounds, T-167317, T-170633, T-005170, T-051702, which is water-soluble and has a specific structure. To identify their molecular targets, we just fixed the compounds onto FG beads.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (66 results)

All 2013 2012 2011 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (42 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Recognition of highly restricted regions in the β-propeller domain of α IIb by platelet-associated anti- α IIb β 3 autoantibodies in primary immune thrombocytopenia.2013

    • Author(s)
      Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y.
    • Journal Title

      Blood

      Volume: 120 Pages: 1499-1509

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK2013

    • Author(s)
      Nakazawa T, Tadokoro S, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
    • Journal Title

      Exp Hematol.

      Volume: 41(1) Issue: 1 Pages: 79-90

    • DOI

      10.1016/j.exphem.2012.09.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-terminal mutation of RUNX1 attenuates the DNA-damage repair response in hematopoietic stem cells2012

    • Author(s)
      Satoh Y, Matsumura I, Tanaka H, Harada H, Harada Y, Matsui K, Shibata M, Mizuki M, Kanakura Y.
    • Journal Title

      Leukemia

      Volume: 26 Pages: 303-311

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells.2012

    • Author(s)
      Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 418 Pages: 811-817

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.2012

    • Author(s)
      Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y.
    • Journal Title

      J Immunol

      Volume: 189 Pages: 200-210

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of vasodilators in patient with pulmonary hypertension associated with hemolytic anemia.2012

    • Author(s)
      Yoshida A, Mizote I, Sakata Y, Maeda T, Kanakura Y, Yamauchi-Takihara K, Komuro I.
    • Journal Title

      J Cardiol Cases

      Volume: 6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria.2012

    • Author(s)
      Murakami Y, Inoue N, Shichishima T, Ohta R, Noji H, Maeda Y, Nishimura JI, Kanakura Y, Kinoshita T.
    • Journal Title

      Br J Haematol

      Volume: 156 Pages: 383-387

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis2012

    • Author(s)
      Sekine Y, Kanakura Y, Sekine Y, Kanakura Y, Oritani K, Matsuda T, et al
    • Journal Title

      Oncogene

      Volume: 10 Issue: 40 Pages: 1038-1038

    • DOI

      10.1038/onc.2011.604

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A lower starting dose of eltrombopag is efficacious in Japanese patients with previously treated chronic immune thrombocytopenia.2012

    • Author(s)
      Y Tomiyama
    • Journal Title

      J Thromb Haemost

      Volume: 10 Issue: 5 Pages: 799-806

    • DOI

      10.1111/j.1538-7836.2012.04695.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-terminal mutation of RUNX1 attenuates the DNA-damage repair response in hematopoietic stem cells2012

    • Author(s)
      Satoh Y, Mizuki M, Kanakura Y, et al
    • Journal Title

      Leukemia

      Volume: 26(2) Issue: 2 Pages: 303-311

    • DOI

      10.1038/leu.2011.202

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia.2012

    • Author(s)
      Kiyomizu K, Kashiwagi H, Nakazawa T, Tadokoro S, Honda S, Kanakura Y, Tomiyama Y.
    • Journal Title

      Blood

      Volume: 120(7) Issue: 7 Pages: 1499-1509

    • DOI

      10.1182/blood-2012-02-409995

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial.2011

    • Author(s)
      Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian CL, Valentine ME, Khursigara G, Ozawa K, Omine M.
    • Journal Title

      Int J Hematol

      Volume: 93 Pages: 36-46

    • NAID

      10029532438

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A potential role for α-actinin in inside-out αIIbβ3 signaling.2011

    • Author(s)
      Tadokoro S, Nakazawa T, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y
    • Journal Title

      Blood

      Volume: 117 Pages: 250-258

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of functional domains and novel binding partners of STIM proteins.2011

    • Author(s)
      Saitoh N, Oritani K, Saito K, Yokota T, Ichii M, Sudo T, Fujita N, Nakajima K, Okada M, Kanakura Y
    • Journal Title

      J Cell Biochem

      Volume: 112 Pages: 147-156

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictability of the response to tyrosine kinase inhibitors via in vitro analysis of Bcr-Abl phosphorylation.2011

    • Author(s)
      Shibata M, Ezoe S, Oritani K, Matsui K, Tokunaga M, Fujita N, Saito Y, Takahashi T, Hino M, Matsumura I, Kanakura Y.
    • Journal Title

      Leuk Res

      Volume: 35 Pages: 1205-1211

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Myeloid neoplasm-related gene abnormalities differentially affect dendritic cell differentiation from murine hematopoietic stem/progenitor cells.2011

    • Author(s)
      Fujita J, Mizuki M, Otsuka M, Ezoe S, Tanaka H, Satoh Y, Fukushima K, Tokunaga M, Matsumura I, Kanakura Y.
    • Journal Title

      Immunol Lett

      Volume: 136 Pages: 61-73

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Constitutive active FGFR3 Lys650Glu mutation enhances the bortezomib-sensitivity in plasma cell malignancy2011

    • Author(s)
      Otsuka M, Mizuki M, Fujita J, Kang S, Kanakura Y.
    • Journal Title

      Anticancer Res

      Volume: 31 Pages: 113-122

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK2011

    • Author(s)
      Saito Y, Shibayama H, Tanaka H, Tanimura A, Kanakura Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 405 Pages: 303-307

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PICOT is a molecule which binds to anamorsin.2011

    • Author(s)
      Saito Y, Shibayama H, Tanaka H, Tanimura A, Matsumura I, Kanakura Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 408 Pages: 329-333

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A_2 receptor.2011

    • Author(s)
      Kamae T, Kiyomizu K, Nakazawa T, Tadokoro S, Kashiwagi H, Honda S, Kanakura Y, Tomiyama Y.
    • Journal Title

      J Thromb Haemost

      Volume: 9 Pages: 1040-1048

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Constitutive active FGFR3 Lys650Glu mutation enhances the bortezomib-sensitivity in plasma cell malignancy.2011

    • Author(s)
      Otsuka M, Kanakura Y, et al
    • Journal Title

      Anticancer Res

      Volume: 31 Pages: 113-122

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK.2011

    • Author(s)
      Saito Y, Kanakura Y, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 405 Pages: 303-307

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Identification of osteoblast stimulating factor-5 as a novel regulator of early lymphocyte development.2012

    • Author(s)
      Fujita N, et al
    • Organizer
      The 17th Congress of the European Hematology Association
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] An anti-apoptotic molecule, Anamorsin, is essential for erythropoiesis through the regulation of cellular labile iron pool2012

    • Author(s)
      Tanimura A, et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] A rare genetic polymorphism in C5 confers poor response to the anti-C5 monoclonal antibody eculizumab by nine Japanese patients with PNH.2012

    • Author(s)
      Nishimura J, et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Platelet-associated anti-GPIIb/IIIa autoantibodies in primary immune thrombocytopenia recognize highly restricted regions in the beta-propeller domain of GPIIb with clonality.2012

    • Author(s)
      Kiyomizu K, et al
    • Organizer
      The 17th Congress of the European Hematology Association
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] Crucial role of complement receptor type 1 on the accumulation of complement component 3 on erythrocytes in patients with PNH treated with eculizumab2012

    • Author(s)
      Yamamoto M, et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 骨髄異形成症候群(MDS)からの急性骨髄性白血病(overt AML)に化学療法とアザシチジンが著効した1症例2012

    • Author(s)
      桐生幸歩 ら
    • Organizer
      第109回日本内科学会講演会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of STAP-2 in BCR-ABL-mediated signals for CML development.2012

    • Author(s)
      Oritani K, et al
    • Organizer
      第3回日本血液学会(JSH)国際シンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Final Research Report
  • [Presentation] The endothelial antigen ESAM monitors hematopoietic stem cell status between dormancy and self-renewal.2012

    • Author(s)
      Sudo T, et al
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      兵庫
    • Related Report
      2012 Final Research Report
  • [Presentation] An anti-apoptotic molecule, Anamorsin, functions in both Fe/S cluster assembly and iron homeostasis.2012

    • Author(s)
      Tanimura A, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of endothelial antigen ESAM in hematopoietic stem cells status.2012

    • Author(s)
      Sudo T, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Detection of change in LIC by MRI in a transfusion dependent MDS patient treated with deferasirox.2012

    • Author(s)
      Hamanaka Y, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Significance of novel HSC marker ESAM expression in cord blood.2012

    • Author(s)
      Ishibashi T, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Energy metabolism of glucose and ATP affects the growth and differentiation of hematopoietic stem/progenitor cells.2011

    • Author(s)
      Matsui K, et al
    • Organizer
      The 16th Congress of the European Hematology Association
    • Place of Presentation
      London, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Constitutive active FGFR3 Lys650Glu mutation enhances the bortezomib-sensitivity in plasma cell malignancy.2011

    • Author(s)
      Otsuka M, et al
    • Organizer
      The 16th Congress of the European Hematology Association
    • Place of Presentation
      London, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Satb1 promotes hematopoietic stem cell differentiation toward the lymphoid lineages.2011

    • Author(s)
      Satoh Y, et al
    • Organizer
      The American Society of Hematology 53rd Annual meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] An anti-apoptotic molecule, Anamorsin, functions in both iron-sulfur protein assembly and cellular iron homeostasis2011

    • Author(s)
      Tanimura A, et al
    • Organizer
      The American Society of Hematology 53rd Annual meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] The endothelial antigen ESAM monitors reversible conversion of hematopoietic stem cells between dormancy and self-renewal.2011

    • Author(s)
      Sudo T, et al
    • Organizer
      The American Society of Hematology 53rd Annual meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] SATB1 induces early lymphocyte differentiation from primitive hematopoietic progenitors.2011

    • Author(s)
      Satoh Y, et al
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] Predictability of the response to tyrosine kinase inhibitors via in vitro analysis of Bcr-Abl signal2011

    • Author(s)
      Shibata M, et al
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] 同種造血細胞移植における ATG(サイモグロブリン)投与後の EB ウイルス再活性化・LPD の発症の検討2011

    • Author(s)
      福島健太郎 ら
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] Recent advance in pathophysiology and treatment of paroxysmal nocturnal hemoglobinuria (PNH): the efficacy and safety profiles of eculizumab in Japanese patients with PNH.2011

    • Author(s)
      Kanakura Y
    • Organizer
      The Taiwan Society of Hematology(招待講演)
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] Recent advance in the treatment of paroxysmal nocturnal hemoglobinuria (PNH): Japanese experience on eculizumab.2011

    • Author(s)
      Kanakura Y
    • Organizer
      The 52nd Korean Society of Hematology(招待講演)
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2011 Research-status Report
  • [Presentation] Identification of osteoblast stimulating factor-5 as a novel regulator of early lymphocyte development

    • Author(s)
      Fujita N,, et al
    • Organizer
      The 17th Congress of the European Hematology Association
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Annual Research Report
  • [Presentation] Platelet-associated anti-GPIIb/IIIa autoantibodies in primary immune thrombocytopenia recognize highly restricted regions in the beta-propeller domain of GPIIb with clonality

    • Author(s)
      Kiyomizu K, et al
    • Organizer
      The 17th Congress of the European Hematology Association
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2012 Annual Research Report
  • [Presentation] A rare genetic polymorphism in C5 confers poor response to the anti-C5 monoclonal antibody eculizumab by nine Japanese patients with PNH

    • Author(s)
      Nishimura J, et al
    • Organizer
      The American Society of Hematology 54th Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨髄異形成症候群(MDS)からの急性骨髄性白血病(overt AML)に化学療法とアザシチジンが著効した1症例

    • Author(s)
      桐生幸歩 ら
    • Organizer
      第109回日本内科学会講演会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of STAP-2 in BCR-ABL-mediated signals for CML development

    • Author(s)
      Oritani K, et al
    • Organizer
      第3回日本血液学会(JSH)国際シンポジウム
    • Place of Presentation
      埼玉
    • Related Report
      2012 Annual Research Report
  • [Presentation] The endothelial antigen ESAM monitors hematopoietic stem cell status between dormancy and self-renewal

    • Author(s)
      Sudo T, et al
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      兵庫
    • Related Report
      2012 Annual Research Report
  • [Presentation] 坐骨神経痛にて発症したNeurolymphomatosisと思われるDLBCLの一例

    • Author(s)
      柴田 大 ら
    • Organizer
      第97回近畿血液学地方会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 造血器腫瘍関連遺伝子異常が樹状細胞分化に及ぼす影響の解析

    • Author(s)
      藤田二郎 ら
    • Organizer
      第22回日本サイトメトリー学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 多発性骨髄腫の予後予測解析ツールとしてのマルチカラー・フローサイトメトリーの可能性

    • Author(s)
      一井倫子 ら
    • Organizer
      第22回日本サイトメトリー学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] OPTIMA試験:高精度フローサイトメトリー法によるGPIアンカー膜蛋白欠損血球の検出

    • Author(s)
      山本正樹 ら
    • Organizer
      第22回日本サイトメトリー学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発作性夜間ヘモグロビン尿症(PNH)の病態と新規抗体療法

    • Author(s)
      金倉 譲
    • Organizer
      第13回日本検査血液学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 癌細胞のPSF1発現レベルは薬剤耐性能および腫瘍再燃に関連する

    • Author(s)
      松井崇浩 ら
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] The proportion of C3 positive RBCs continuously increase during eculizumab treatment in PNH

    • Author(s)
      Yamamoto M, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Significance of novel HSC marker ESAM expression in cord blood

    • Author(s)
      Ishibashi T, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] An anti-apoptotic molecule, Anamorsin, functions in both Fe/S cluster assembly and iron homeostasis

    • Author(s)
      Tanimura A, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] PA anti-GPIIb/IIIa Abs in primary ITP recognize highly restricted regions in GPIIb with clonality

    • Author(s)
      Kiyomizu K, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of endothelial antigen ESAM in hematopoietic stem cells status

    • Author(s)
      Sudo T, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Detection of change in LIC by MRI in a transfusion dependent MDS patient treated with deferasirox

    • Author(s)
      Hamanaka Y, et al
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 重篤な天疱瘡で発症した濾胞性リンパ腫の一例

    • Author(s)
      谷 瑞季 ら
    • Organizer
      第98回近畿血液学地方会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] The endothelial antigen ESAM level distinguishes HSC status between quiescence and self-renewal

    • Author(s)
      Sudo T, et al
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Annual Research Report
  • [Book] Advances in Hematopoietic Stem Cell Research2012

    • Author(s)
      Yokota T, Oritani K, Butz S, Ewers S, Vestweber D, Kanakura Y.
    • Publisher
      Intech Open Access Publisher
    • Related Report
      2012 Final Research Report
  • [Remarks] 大阪大学 医学系研究科 血液・腫瘍内科 ホームページ

    • URL

      http://www.hematology.pro/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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