Crosstalk between graft-versus-host disease and infection following allogeneic hematopoietic stem cell transplantation
| Project/Area Number |
23659490
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Hokkaido University (2012)
Kyushu University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKASHIMA Shuichirou 九州大学, 大学病院, 助教 (70622116)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GVHD / Paneth cell / defensin / ＧＶＨＤ / 感染症 / 造血幹細胞移植 / パネート細胞 / デフェンシン |
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| Research Abstract |
We discovered that Paneth cells are targeted by GVHD, resulting in marked reduction in the expression of α-defensins, which selectively kill non-commensals, while preserving commensals. Molecular profiling of intestinal microbial communities showed loss of physiological diversity among the microflora and the overwhelming expansion of otherwise rare bacteria, which caused septicemia. These results reveal the novel mechanism responsible for shift in the gut flora from commensals towards the widespread prevalence of pathogens and the previously unrecognized association between GVHD and infection following allogeneic stem cell transplantation.
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Report
(3 results)
Research Products
(67 results)
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[Journal Article] Plasma biomarker of lower gastrointestinal and liver acute graft-versus-host disease2012
Author(s)
Harris AC, Ferrara JL, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Landfried K, Akashi K, Vander Lugt MT, Couriel DR, Reddy P, Paczesny S
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Journal Title
Blood
Volume: 119-12
Pages: 2960-2963
Related Report
Peer Reviewed
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[Journal Article] Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation2012
Author(s)
Mori Y, Miyamoto T, Kato K, Kamezaki K, Kuriyama T, Oku S, Takenaka K, Iwasaki H, Harada N, Shiratsuchi M, Abe Y, Nagafuji K, Teshima T, Akashi K
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Journal Title
Biol Blood Marrow Transplant
Volume: 18-3
Pages: 458-465
Related Report
Peer Reviewed
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[Journal Article] Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by downregulating Th1 and Th172012
Author(s)
Nishimori H, Maeda Y, Teshima T, Sugiyama H, Kobayashi K, Yamasuji Y, Kadohisa S, Uryu H, Takeuchi K, Tanaka T, Yoshino T, Iwakura Y, Tanimoto M
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Journal Title
Blood
Volume: 119-1
Pages: 285-295
NAID
Related Report
Peer Reviewed
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[Journal Article] Regenerating islet-derived 3 alpha is a biomarker of gastrointestinal graft-versus-host disease2011
Author(s)
Ferrara JL, Harris AC, Greenson JK, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Huber E, Landfried K, Akashi K, Vander Lugt M, Reddy P, Chin A, Zhang Q, Hanash S, Paczesny S
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Journal Title
Blood
Volume: 118-25
Pages: 6702-6708
Related Report
Peer Reviewed
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[Journal Article] Role of autotransplantation in the treatment of acute promyelocytic leukemia patients in remission: fukuoka BMT group observations and a literature review2011
Author(s)
Kamimura T, Miyamoto T, Nagafuji K, Numata A, Henzan H, Takase K, Ito Y, Ohno Y, Fujisaki T, eto T, Takamatsu Y, Teshima T, Gondo H, Akashi K, Taniguchi S, Harada M
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Journal Title
Bone Marrow Transplant
Volume: 46
Pages: 820-826
Related Report
Peer Reviewed
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[Journal Article] Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic stem cell transplantation2011
Author(s)
Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M
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Journal Title
J Exp Med
Volume: 208-5
Pages: 1069-1082
Related Report
Peer Reviewed
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[Journal Article] Analysis of immune reconstitution after autologous CD34+ stem⁄progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells2011
Author(s)
Tsukamoto H, Nagafuji K, Horiuchi T, Mitoma H, Niiro H, Arinobu Y, Inoue Y, To K, Miyamoto T, Iwasaki H, Teshima T, Harada M, Akashi K
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Journal Title
Rheumatology
Volume: 50-5
Pages: 944-952
Related Report
Peer Reviewed
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[Presentation] A Prospective Feasibility Trial of Unrelated Bone Marrow Transplantation with Reduced Intensity Conditioning Regimen for Elderly Patients with Adult T-Cell Leukemia/Lymphoma (ATL)2011
Author(s)
Eto T, Choi I, Tanosaki R, Takatsuka Y, Utsunomiya A, Takemoto S, Taguchi J, Fukushima T, Kato K, Teshima T, Suehiro Y, Yamanaka T, Okamura J, Uike N
Organizer
53rd ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Related Report
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[Presentation] A Novel Grading System of Lower Gastrointestinal Acute Graft-Versus-Host Disease At Disease Onset Predicts Response to Therapy and Non-Relapse Mortality2011
Author(s)
Harris AC, Ferrara JLM, Greenson JK, Braun TM, Holler E, Teshima T, Levine JE, Choi SWJ, Huber E, Landfried K, Akashi K, Vander Lugt MT, Reddy P, Chin A, Zhang Q, Hanash S and Paczesny S
Organizer
53rd ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Mesenchymal Stem Cells As a Treatment for Steroid-Resistant Acute Graft Versus Host Disease (aGVHD); A Multicenter Phase I/II Study2011
Author(s)
Ozawa Y, Goto T, Ohashi K, Murata M, Eto T, Kobayashi N, Taniguchi S, Imamura M, Ando K, Kato S, Mori T, Teshima T, Mori M, Muroi K, Miyamura K, Ozawa K
Organizer
53rd ASH Annual Meeting and Exposition
Place of Presentation
San Diego, USA
Related Report
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[Presentation] Myeloablative coditioning cord bllod transplant: Resalts of prospective study FBMTG-01 full CBT2011
Author(s)
Oku E, Nagafuji K, Osaki K, Mori Y, Morishige S, Henzan H, Tanimoto K, Yoshimoto G, Kamimura T, Eto T, Kamezaki K, Teshima T, Miyamoto T, Akashi K
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Related Report
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[Presentation] Successful reduced-intensity cord blood transplantation for advanced mycosis fungoides2011
Author(s)
Nakaike T, Oku S, Kato K, Sakamoto K, Shimoji S, Kuriyama T, Mori Y, Takenaka K, Kuroiwa M, Harada N, Iwasaki H, Miyamoto T, Teshima T, Oshima K, Akashi K
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Related Report
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[Presentation] BK virus hemorrhagic cystitis in allo-HSCT: Is seasonal distribution caused by nosocomial infection?2011
Author(s)
Kato K, Miyamoto T, Oku S, Kuriyama T, Mori Y, Takenaka K, Harada N, Iwasaki H, Murata M, Furusho N, Shimono N, Teshima T, Hayashi J, Akashi K
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Related Report
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[Presentation] Preemptive therapy for cytomegalovirus infection by low dose valganciclovir after allogeneic HSCT2011
Author(s)
Takenaka K, Nagafuji K, Takase K, Kamimura T, Nishi Y, Kato K, Henzan H, Ito Y, Harada N, Miyamoto T, Eto T, Akashi K, Teshima T
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Related Report
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[Presentation] Non myeloablative conditioning cord blood transplant: Results of prospective study FBMTG02 mini CBT2011
Author(s)
Oku E, Nagafuji K, Tanimoto K, Yoshimoto G, Kondo S, Takase K, Nagasawa E, Mori Y, Takenaka K, Eto T, Kamezaki K, Teshima T, Miyamoto T, Akashi K
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋
Related Report
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