| Project/Area Number |
23659490
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Hokkaido University (2012)
Kyushu University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKASHIMA Shuichirou 九州大学, 大学病院, 助教 (70622116)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GVHD / Paneth cell / defensin / ＧＶＨＤ / 感染症 / 造血幹細胞移植 / パネート細胞 / デフェンシン |
|---|
| Research Abstract |
We discovered that Paneth cells are targeted by GVHD, resulting in marked reduction in the expression of α-defensins, which selectively kill non-commensals, while preserving commensals. Molecular profiling of intestinal microbial communities showed loss of physiological diversity among the microflora and the overwhelming expansion of otherwise rare bacteria, which caused septicemia. These results reveal the novel mechanism responsible for shift in the gut flora from commensals towards the widespread prevalence of pathogens and the previously unrecognized association between GVHD and infection following allogeneic stem cell transplantation.
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