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Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulin

Research Project

Project/Area Number 23659491
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionKagoshima University

Principal Investigator

MARUYAMA Ikuro  鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)

Co-Investigator(Kenkyū-buntansha) KAWAHARA Koichi  大阪工業大学, 工学部, 教授 (10381170)
HASHIGUCHI Teruto  鹿児島大学, 大学院・医歯総合研究科, 教授 (70250917)
OYAMA Yoko  鹿児島大学, 医学部・歯学部附属病院, 特任助教 (20583470)
ITO Takashi  鹿児島大学, 大学院・医歯総合研究科, 特任講師 (20381171)
Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords血栓 / 止血学 / トロンボモジュリン / トロンビン / HMGB1 / DIC / des-HMGB1
Research Abstract

We previously showed that HMGB1 binds to thrombomodulin(TM) and degraded by thrombin-TM at the N-terminus of the molecule cleaving out 10 aminoacdid-residue. We named this degraded HMGB1 as des-HMGB1. We also have showed that des-HMGB1 compete with intact binding to its receptor RAGE, Toll-like receptor-2 and-4 resulting negatively regulating of intact HMGB1 and its receptor signaling.
In this study, we established the des-HMGB1 specific assay ELISA, and investigated its dynamism in various diseases including DIC, sepsis and shock. We showed that the des-HMGB1 was increased in the serum from the patients with these pathologic conditions, especially in the cases treated with recombinant TM. We are now further studying relationship between des-HMGB1 levels and the efficacy of TM treatment and their prognosis.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (16 results)

All 2012 2011

All Journal Article (16 results) (of which Peer Reviewed: 15 results)

  • [Journal Article] Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine2012

    • Author(s)
      Kojima M, Tanabe M, Shinoda M, Yamada S, Miyasho T, Suda K, Hibi T, Obara H, Itano O, Kawachi S, Kitajima M, Maruyama I, Kitagawa Y.
    • Journal Title

      J Surg Res

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction2012

    • Author(s)
      Hashimoto T, Ishii J, Kitagawa F, Yamada S, Hattori K, Okumura M, Naruse H, Motoyama S, Matsui S, Tanaka I, Izawa H, Maruyama I, Nomura M, Ozaki Y.
    • Journal Title

      Atherosclerosis

      Volume: 221(2) Pages: 490-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice2012

    • Author(s)
      Kohno M, Watanabe M, Izumi Y, Tasaka S, Kitagawa Y, Maruyama I, Kobayashi K.
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60(2) Pages: 124-30

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims2012

    • Author(s)
      Oda Y, Tsuruta R, Fujita M, Kaneda K, Kawamura Y, Izumi T, Kasaoka S, Maruyama I., Maekawa T
    • Journal Title

      A pilot study

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine2012

    • Author(s)
      Kojima M, Maruyama I, Kitagawa Y, et al
    • Journal Title

      J Surg Res

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction2012

    • Author(s)
      Hashimoto T, Maruyama I, Ozaki Y., et al
    • Journal Title

      Atherosclerosis

      Volume: 221 Pages: 490-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims : A pilot study2012

    • Author(s)
      Oda Y, Maruyama I, Maekawa T, et al
    • Journal Title

      Resuscitation

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011

    • Author(s)
      Takashi Ito & Ikuro Maruyama.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 9 Pages: 168-173

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011

    • Author(s)
      伊藤隆史、丸山征郎
    • Journal Title

      臨床血液

      Volume: 52 Pages: 356-360

    • NAID

      130004501537

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release o f high-mobility group box 12011

    • Author(s)
      Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K.
    • Journal Title

      Shock 2011

      Volume: 36(5) Pages: 494-500

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011

    • Author(s)
      Ito T, Maruyama I.
    • Journal Title

      J Thromb Haemost

      Volume: 1 Pages: 168-73

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Ohkouchi S, Tamada T, Nishimura H, Ishizaka A, Maruyama I, Okada Y, Takashi K, Nukiwa T.
    • Journal Title

      Pulm Med

      Volume: 2011 Pages: 916486-916486

    • NAID

      120005761658

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valproic acid increases susceptibilty to endotoxin shock through enhanced release of high-mobility group box 12011

    • Author(s)
      Sugiura S, Maruyama I, Matsushita K, et al
    • Journal Title

      Shock

      Volume: 36(5) Pages: 494-500

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation J2011

    • Author(s)
      Ito T, Maruyama I
    • Journal Title

      Thromb Haemost

      Volume: 9 Pages: 168-73

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gradualincrease of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Maruyama I, Nukiwa T, et al
    • Journal Title

      Pulm Med

      Volume: 2011 Pages: 916486-916486

    • NAID

      120005761658

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice2011

    • Author(s)
      Kohno M, Maruyama I, Kobayashi K, et al
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60 Pages: 124-30

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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