| Project/Area Number |
23659492
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ADACHI Noritaka 横浜市立大学, 生命ナノシステム科学研究科, 教授 (30264675)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIYAMA Akira 横浜市立大学, 医学研究科, 准教授 (80589664)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | エピジェネティックメモリー / ヒストンH3.3 / 細胞分化 / マクロファージ / 網羅的解析 / 国際情報交流 / 米国 / 転写 |
|---|
| Research Abstract |
Cell differentiation in multicellular organisms is achieved by dynamic changes in gene expression pattern. Dysregulation of such processes can cause various diseases including cancers. Histone variant H3.3 plays an important role in epigenetic memory of active genes. In this study we mapped genome-wide distribution of H3.3 during macrophage differentiation. The results indicated that H3.3 may regulate several steps of transcription including elongation. We also identified H3.3K36 as an amino acid residue required for H3.3 incorporation into chromatin.
|
