• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Reduction of memory Th2 cell pool for the treatment of allergic diseases

Research Project

Project/Area Number 23659496
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionChiba University

Principal Investigator

NAKAJIMA Hiroshi  千葉大学, 大学院・医学研究院, 教授 (00322024)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsメモリーTh2 細胞 / 気管支喘息 / 肺血管リモデリング / IL-25 / Th2細胞 / メモリーTh2細胞 / シグナルシークエンストラップ法 / DNAマイクロアレイ
Research Abstract

The characteristics of asthma are mainly mediated by antigen-specific memory Th2 cells and their cytokines including IL-4, IL-5, and IL-13. In this study, we tried to identify cell surface molecules specific for memory Th2 cells by using DNA microarray analysis and retrovirus-mediated signal sequence trap screening. However, unfortunately, we could not identify memory Th2 cell-specific molecules within this research period. On the other hand, we found that prolonged Th2-type immune inflammation in the lung induces the expression of IL-25 and pulmonary arterial remodeling (PAR). Injection of anti-IL-25 antibody inhibited antigen-induced PAR. Lung-specificIL-25 transgenic mice (CC10 IL-25 mice) but not CC10 IL-25 NKT^<-/-> mice spontaneouslydeveloped PAR. These results suggest that prolonged expression of IL-25 in the lung induces PARby NKT cell-dependent mechanisms.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (5 results) (of which Invited: 1 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Roles of Ca^<2+>-IKK2 signaling in mast cells.2013

    • Author(s)
      Hosokawa J, Suzuki K, Nakagomi D, Tamachi T, Takatori H, Suto A, Nakajima H.
    • Journal Title

      Int. Arch. Allergy Immunol.

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-25 induces pulmonary arterial remodeling by NKT cell-dependent mechanisms.2013

    • Author(s)
      Kawashima S, Hirose K, Takahashi T, Tamachi T, Ikeda K, Tokoyoda K, Nakayama T, Nakajima H.
    • Journal Title

      Int. Arch. Allergy Immunol.

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis.2013

    • Author(s)
      Tanaka S, Ikeda K, Uchiyama K, Iwamoto T, Sanayama Y, Okubo A, Nakagomi N, Takahashi K, Yokota M, Suto A, Suzuki K, Nakajima H.
    • Journal Title

      Rheumatology (Oxford)

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Confirming the presence of synovitis with ultrasound improves the accuracy of 2010 ACR/EULAR classification criteria for rheumatoid arthritis.2013

    • Author(s)
      Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori T, Suzuki K, Takabayashi K, Nakajima H.
    • Journal Title

      Arthritis Rheum.

      Volume: 65(4) Pages: 890-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pre-dinner administration increases the efficacy of proton pump inhibitors on refractory GERD symptoms in connective tissue disease patients.2013

    • Author(s)
      Iwata A, Ikeda K, Hirose K, Takatori H, Takahashi K, Suzuki Y, Tanaka S, Suto A, Nakajima H.
    • Journal Title

      ModRheumatol.

      Volume: 23 Pages: 357-364

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] B and T lymphocyte attenuator expressed on CD8+ T cells inhibits contact hypersensitivity reaction.2013

    • Author(s)
      Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Shimada S, Nakajima H.
    • Journal Title

      J Invest Dermatol.

      Volume: 133 Pages: 702-711

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing TLR4signaling in innate immune cells. Proc. Natl.2013

    • Author(s)
      Kobayashi Y, Iwata A, Suzuki K, Suto A, Kawashima S, Saito Y, Owada T, Kobayashi M, Watanabe N, Nakajima H.
    • Journal Title

      Acad. Sci. USA.

      Volume: 110 Pages: 5121-5126

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bucillamine-induced yellow nail in Japanese patients with rheumatoid arthritis: two case reports and a review of 33 reported cases.2013

    • Author(s)
      Nakagomi D, Ikeda K, Kawashima H, Kobayashi Y, Suto A, Nakajima H.
    • Journal Title

      Rheumatol Int.

      Volume: 33(3) Pages: 793-797

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-25 induces pulmonary arterial remodeling by NKT cell-dependent mechanisms.2013

    • Author(s)
      Kawashima S, Hirose K, Takahashi T, Tamachi T, Ikeda K, Tokoyoda K, Nakayama T, Nakajima H
    • Journal Title

      Int. Arch. Allergy Immunol.

      Volume: 160 Suppl 1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.2013

    • Author(s)
      Kobayashi Y, Iwata A, Suzuki K, Suto A, Kawashima S, Saito Y, Owada T, Kobayashi M, Watanabe N, Nakajima H.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 26 Issue: 13 Pages: 5121-6

    • DOI

      10.1073/pnas.1222093110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of CRTH2+ CD4+ T cells in IgG4-related lacrimal gland enlargement.2012

    • Author(s)
      Saito Y, Kagami S-I, Kawashima S, Takahashi K, Ikeda K, Hirose K, Oshitari T, Yamamoto S, Okamoto Y, Nakajima H.
    • Journal Title

      Int. Arch. Allergy Immunol.

      Volume: 158 Pages: 42-46

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-glucan curdlaninduces IL-10-producing CD4+ T cells andinhibits allergic airway inflammation.2012

    • Author(s)
      Kawashima S, Hirose K, Iwata A, Takahashi T, Ohkubo A, Tamachi T, Ikeda K Kagami S, Nakajima H.
    • Journal Title

      J Immunol.

      Volume: 189 Pages: 5713-5721

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of IKK subunits in mast cell degranulation.Int.2012

    • Author(s)
      Nakagomi D, Suzuki K, Nakajima H.
    • Journal Title

      Arch. Allergy Immunol.

      Volume: 158 Pages: 92-95

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of CRTH2+ CD4+ T cells in immunoglobulin G4-related lacrimal gland enlargement.2012

    • Author(s)
      Saito Y, Kagami S, Kawashima S, Takahashi K, Ikeda K, Hirose K, Oshitari T, Yamamoto S, Okamoto Y, Nakajima H
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 158 Suppl 1 Issue: Suppl. 1 Pages: 42-46

    • DOI

      10.1159/000337761

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] beta-glucan Curdlan induces IL-10-producing CD4+T cells and inhibits allergic airway inflammation2012

    • Author(s)
      Kawashima S, Hirose K, Iwata A, Takahashi K, Ohkubo A, Tamachi T, Ikeda K, Kagami S, Nakajima H
    • Journal Title

      J Immunol

      Volume: 189 Issue: 12 Pages: 5713-5721

    • DOI

      10.4049/jimmunol.1201521

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of CRTH2+ CD4+ T cells in IgG4-related lacrimal gland enlargement2012

    • Author(s)
      Saito Y, Kagami S-I, Kawashima S, Takahashi K, et al
    • Journal Title

      nt. Arch. Allergy Immunol.

      Volume: 158

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation2011

    • Author(s)
      Suzuki K, Murphy SH, Xia Y, Yokota M, Nakagomi D, Liu F, Verma IM, Nakajima H
    • Journal Title

      PLoS One

      Volume: 6 Issue: 9 Pages: e25412-e25412

    • DOI

      10.1371/journal.pone.0025412

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] IL-25はNKT細胞を介して肺動脈炎,肺動脈平滑筋増生を誘発する2012

    • Author(s)
      川島沙紀、廣瀬晃一、玉地智宏、鈴木浩太郎、中島裕史
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Crucialrolesofmastcellsinamurinemodelofpolymyositis2012

    • Author(s)
      YokotaM,SuzukiK,TokoyodaT,NakagomiD,NakayamaN,KohsakaH,IwamotoI,NakajimaH
    • Organizer
      99thAnnualmeetingoftheTheAmericanAssoiciationofImmunologists,
    • Place of Presentation
      Boston,U.S.A.
    • Year and Date
      2012-05-06
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation2012

    • Author(s)
      Takahashi K, Kawashima S, Niwa Y, Iwata A, Kobayashi Y, Kagami S, Suto A, Hirose K, Watanabe N, Nakayama T, Nakajima H
    • Organizer
      99th Annual meeting of the The American Assoiciation ofImmunologists
    • Place of Presentation
      Boston, U.S.A.
    • Year and Date
      2012-05-06
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-17ファミリーサイトカインとアレルギー2012

    • Author(s)
      中島裕史
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] アレルギー性気道炎症:最近の話題

    • Author(s)
      中島裕史
    • Organizer
      第5回相模原臨床アレルギーセミナー(招待講演)
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/allergy/kenkyugyouseki.html

    • Related Report
      2012 Final Research Report
  • [Remarks] http://www.m.chiba-u.jp/class/allergy/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.jp/class/gene/index.html

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] T ヘルパー17 細胞分化の抑制剤2012

    • Inventor(s)
      中島裕史, 他12名
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2012-168518
    • Filing Date
      2012-07-30
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 関節リウマチに対する抗IL-6受容体抗体療法の有効性の予測方法2011

    • Inventor(s)
      中島裕史、池田 啓、他7名
    • Industrial Property Rights Holder
      千葉大学
    • Industrial Property Number
      2011-156921
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi