The circadian clocks condition neuronal/endocrine/immune axis

• Project/Area Number: 23659499
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: University of Yamanashi
• Principal Investigator: NAKAO Atsuhito 山梨大学, 大学院・医学工学総合研究部, 教授 (80317445)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 体内時計 / 神経 / 内分泌 / 免疫 / マスト細胞 / アレルギー反応 / アレルギー・ぜんそく / 医療・福祉

Research Abstract

This study showed that the time of day-dependent variation in the skin allergic reaction observed in the sham-operated mice was absent in the mice with the physical ablation of the SCN. In addition, the time of day-dependent variation in the skin allergic reaction was absent in the mice with specific deletion of the Clock gene in mast cells. These results suggest the circadian clocks drive the daily rhythms in the skin allergic reaction by mediating temporal regulation of the nervous/endocrine/immune systems.

Research Products

• [Journal Article] Mast cells play a key role in host defense against herpes simplex virus infection through TNF-a and IL-6 production (2013)
  • Author(s): Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakaw S, Nakao A, Moriishi K, Nishiyama Y, Shimada S
  • Journal Title: J Invest Dermatol
  • Peer Reviewed
• [Journal Article] Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G (2013)
  • Author(s): Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G
  • Journal Title: Chronobiol Int
  • Peer Reviewed
• [Journal Article] Endogenous TGF-ss activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-kB activation (2013)
  • Author(s): Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, Nakamura Y, Katoh R, Haro H, Nakao A
  • Journal Title: J Orthop Res
  • Peer Reviewed
• [Journal Article] Biological clock dysfunction exacerbates contact hypersensitivity in mice (2013)
  • Author(s): Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S
  • Journal Title: Brit J Dermatol Volume: 168(1) Pages: 39-46
  • Peer Reviewed
• [Journal Article] Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production (2013)
  • Author(s): Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S
  • Journal Title: J Invest Dermatol Volume: 133(9) Issue: 9 Pages: 2170-9
  • DOI: 10.1038/jid.2013.150
  • Peer Reviewed
• [Journal Article] Cross-talk between the circadian clock circuitry and the immune system. (2013)
  • Author(s): Cermakian N
  • Journal Title: Chronobiol Int Volume: im press
  • Peer Reviewed
• [Journal Article] Endogenous TGF-β activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-κB activation (2013)
  • Author(s): Yong Zhu
  • Journal Title: J Orthop Res Volume: im press Issue: 7 Pages: 1144-1149
  • DOI: 10.1002/jor.22337
  • Peer Reviewed
• [Journal Article] Biological clock dysfunction exacerbates contact hypersensitivity in mice. (2013)
  • Author(s): Takita E
  • Journal Title: Brit J Dermatol Volume: 168(1) Pages: 39-46
  • Peer Reviewed
• [Journal Article] Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation (2013)
  • Author(s): Sugiyama T, Kitamura M, Sugita K, Okuda T, Hisamoto M, and Nakao A
  • Journal Title: Am J Enol Viticult Volume: (in press) Issue: 1 Pages: 146-151
  • DOI: 10.5344/ajev.2012.11131
  • Peer Reviewed
• [Journal Article] Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation (2012)
  • Author(s): Sugiyama T, Kitamura M, Sugita K, Hisamoto M, Okuda T, Nakao A
  • Journal Title: Am J Enol Viticult
  • Peer Reviewed
• [Journal Article] Dietary resveratrol prevents the development of food allergy in mice (2012)
  • Author(s): Okada Y, Oh-oka K, Nakamura Y, Ishimaru K, Matsuoka S, Okumura K, Ogawa H, Hisamoto M, Okuda T, Nakao A
  • Journal Title: PLoS One Volume: 7(9)
  • Peer Reviewed
• [Journal Article] Severe dermatitis with loss of epidermal langerhans cells in human and mouse zinc deficiency (2012)
  • Author(s): Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta T, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S
  • Journal Title: J Clin Invest Volume: 122(2) Pages: 722-732
  • Peer Reviewed
• [Journal Article] Transforming growth factor-ss(1) promotes nasal mucosal mast cell chemotaxis in murine experimental allergic rhinitis (2012)
  • Author(s): Ouyang Y, Nakao A, Han D, Zhang L
  • Journal Title: ORL J Otorhinolaryngol Relat Spec Volume: 74(3) Pages: 117-123
  • Peer Reviewed
• [Journal Article] Dietary resveratrol prevents the development of food allergy in mice (2012)
  • Author(s): Okada, Y., K. Oh-oka, Y. Nakamura, K. Ishimaru, S. Matsuoka, K. Okumura, H. Ogawa, M. Hisamoto, T. Okuda, and A. Nakao
  • Journal Title: PLoS One Volume: 7 Issue: 9 Pages: e44338-e44338
  • DOI: 10.1371/journal.pone.0044338
  • Peer Reviewed
• [Journal Article] Transforming growth factor-β(1) promotes nasal mucosal mast cell chemotaxis in murine experimental allergic rhinitis. (2012)
  • Author(s): Ouyang Y
  • Journal Title: ORL J Otorhinolaryngol Relat Spec Volume: 74(3) Issue: 3 Pages: 117-123
  • DOI: 10.1159/000328587
  • Peer Reviewed
• [Journal Article] 体内時計とアレルギー (2012)
  • Author(s): 中尾篤人
  • Journal Title: 治療 Volume: 94(11) Pages: 1859-1864
• [Journal Article] 体内時計によるアレルギー反応の時間的制御 (2012)
  • Author(s): 中尾篤人
  • Journal Title: 感染 炎症 免疫 Volume: 42(3) Pages: 58-61
• [Journal Article] アレルギー疾患における体内時計の役割 (2012)
  • Author(s): 中尾篤人
  • Journal Title: アレルギーの臨床 Volume: 32(434) Pages: 32-36
• [Journal Article] 食物アレルギーとその動物モデル (2012)
  • Author(s): 中尾篤人
  • Journal Title: アレルギーの臨床 Volume: 32(433) Pages: 48-52
• [Journal Article] アレルギーと体内時計 (2012)
  • Author(s): 中尾篤人
  • Journal Title: FOOD STYLE21 Volume: 2012年7月 Pages: 24-26
  • NAID: 40019365671
• [Journal Article] 肥満細胞によるアレルギー反応の体内時計遺伝子を介する日内変動調節 (2012)
  • Author(s): 中尾篤人
  • Journal Title: 炎症と免疫 Volume: 20(4) Pages: 3-7
• [Journal Article] アレルギーと体内時計 (2012)
  • Author(s): 中尾篤人
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(6) Pages: 681-685
  • NAID: 40019365671
• [Presentation] アレルギーの分子時計メカニズム (2013)
  • Author(s): 中尾篤人
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場（福岡市）
• [Presentation] 「融合研究の推進」～共同研究や臨床応用への可能性～ (2013)
  • Author(s): 中尾篤人
  • Organizer: 山梨大学 融合研究臨床応用推進センター第２回講演会
  • Place of Presentation: 山梨大学（甲府市）
• [Presentation] アレルギーと体内時計 (2013)
  • Author(s): 中尾篤人
  • Organizer: 第21回大分アレルギー講習会
  • Place of Presentation: 大分大学（大分市）
• [Presentation] 教育講演]TSLPとアレルギー (2012)
  • Author(s): 中尾篤人
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2012-11-30
• [Presentation] マスト細胞の内在時計による即時型皮膚反応の日内変動の調節 (2012)
  • Author(s): 中村勇規,中尾篤人,柴田重信
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2012-11-29
• [Presentation] マスト細胞の内在時計による即時型皮膚反応の日内変動の調節 (2012)
  • Author(s): 中村勇規,中尾篤人,柴田重信
  • Organizer: 第14回応用薬理シンポジウム
  • Place of Presentation: ベルクラシック甲府(甲府市)
  • Year and Date: 2012-09-03
• [Presentation] アレルギーと体内時計 (2012)
  • Author(s): 中尾篤人
  • Organizer: 第14回応用薬理シンポジウム
  • Place of Presentation: ベルクラシック甲府(甲府市)
  • Year and Date: 2012-09-03
• [Presentation] TSLPとアレルギー (2012)
  • Author(s): 中尾篤人
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] マスト細胞の内在時計による即時型皮膚反応の日内変動の調節 (2012)
  • Author(s): 中村勇規
  • Organizer: .第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] 関節リウマチとTGF-β (2012)
  • Author(s): 中尾篤人
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] Colostrum feeding and immunological substance in colostrum among lactating women from urban and rural environments, Nepal (2012)
  • Author(s): Aihara Y
  • Organizer: 44th Asia-Pacific Academic Consortium for Public Health
  • Place of Presentation: University of Colombo（Colombo, Sri Lanka）
• [Presentation] アレルギーと体内時計 (2012)
  • Author(s): 中尾篤人
  • Organizer: 第14回応用薬理シンポジウム
  • Place of Presentation: ベルクラシック甲府（甲府市）
• [Presentation] マスト細胞の内在時計による即時型皮膚反応の日内変動の調節 (2012)
  • Author(s): 中村勇規
  • Organizer: 第14回応用薬理シンポジウム
  • Place of Presentation: ベルクラシック甲府（甲府市）
• [Presentation] アレルギーと体内時計 (2012)
  • Author(s): 中尾篤人
  • Organizer: ifia JAPAN2012（第17回国際食品素材／添加物展・会議、HFE JAPAN2012（第10回ヘルスフードエキスポ）
  • Place of Presentation: 東京ビッグサイト（東京都）
• [Presentation] アレルギーと体内時計 (2011)
  • Author(s): 中尾篤人
  • Organizer: 第61回日本アレルギー学会秋季学術大会(招待講演)
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] The circadian clock gene Period2 regulates a daily (2011)
  • Author(s): 中尾篤人
  • Organizer: 第40回日本免疫学会学術集会(招待講演)
  • Place of Presentation: 幕張メッセ（千葉県）
• [Presentation] Circadian clock gene Period2 regulates intestinal (2011)
  • Author(s): 大岡杏子、中尾篤人
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Remarks] 山梨大学研究者総覧
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispDetail.Scholar