Analysis of pathogenesis of IgG4-related disease
| Project/Area Number |
23659503
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEGAMI Tsutomu 金沢医科大学, 総合医学研究所, 教授 (10113490)
TOMOSUGI Naohisa 金沢医科大学, 総合医学研究所, 教授 (80155580)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUSHIMA Toshihiro 金沢医科大学, 医学部, 准教授 (60251998)
MASAKI Yasufumi 金沢医科大学, 医学部, 准教授 (40238895)
KAWANAMI Takafumi 金沢医科大学, 医学部, 講師 (20350762)
FUJITA Yoshimasa 金沢医科大学, 医学部, 講師 (70450880)
ISHIGAKI Yasuto 金沢医科大学, 総合医学研究所, 講師 (20232275)
SAWAKI Toshioki 金沢医科大学, 医学部, 助教 (90534694)
SAKAI Tomoyuki 金沢医科大学, 医学部, 助教 (90566902)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膠原病学 / IgG4 / IgG4関連疾患 / ミクリッツ病 / 自己免疫性膵炎 / 自然免疫 / 獲得免疫 / DNAマイクロアレイ / 炎症学 |
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| Research Abstract |
IgG4-related disease (IgG4-RD) is a new disease concept first recognized in the 21st century. The condition is characterized by elevated serum IgG4 values and marked IgG4-positive plasma cell infiltration of affected lesions. Pathogenesis of IgG4-RD is still unclear. We have done DNA microarray and proteomics analysis to investigate its pathogenesis.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Research Program for Intractable Diseaseby Ministry of Health,Laborand Welfare (MHLW) Japan G4 team.2012
Author(s)
Umehara,H.,K.Okazaki,Y.Masaki,M.Kawano,M.Yamamoto,T.Saeki,S.Matsui,T.Sumida,T.Mimori,Y.Tanaka,K.他andthe
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Journal Title
ModRheum
Volume: 22(1)
Pages: 1-14
Related Report
Peer Reviewed
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[Journal Article] Henoch-Schonlein purpura nephritis in a patient with IgG4-related disease Apossible association.2012
Author(s)
ItoK,Yamada K,Mizushima I,Aizu M,Fujii H,Mizutomi K,Matsumura M,Hayashi K,Yamagish M,Umehara H,Yamaguchi Y,Nagata M,and Kawano M.
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Journal Title
Related Report
Peer Reviewed
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