Killer T cell inducing peptide vaccine against malaria infection

Research Project

Project/Area Number	23659504
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Infectious disease medicine
Research Institution	Hokkaido University
Principal Investigator	KAJINO Kiichi 北海道大学, 人獣共通感染症リサーチセンター, 准教授 (80322147)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	感染症防御学 / マラリア / ペプチドワクチン / 細胞性免疫 / キラー活性 / CTLワクチン
Research Abstract	Six potent Cytotoxic T cell inducing 9mer peptide that derived from Plasmodium falciparum were indentified. Out of 6, immunization of HLA-A24 transgenic mice with 3 peptides partially protected mice from lethal malaria infection. This results suggest that CTL inducing malaria vaccine is promising new vaccine.

Report

(3 results)