Killer T cell inducing peptide vaccine against malaria infection
Project/Area Number |
23659504
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
|
Research Institution | Hokkaido University |
Principal Investigator |
KAJINO Kiichi 北海道大学, 人獣共通感染症リサーチセン ター, 准教授 (80322147)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 感染症防御学 / マラリア / ペプチドワクチン / 細胞性免疫 / キラー活性 / CTLワクチン |
Research Abstract |
Six potent Cytotoxic T cell inducing 9mer peptide that derived from Plasmodium falciparum were indentified. Out of 6, immunization of HLA-A24 transgenic mice with 3 peptides partially protected mice from lethal malaria infection. This results suggest that CTL inducing malaria vaccine is promising new vaccine.
|
Report
(3 results)
Research Products
(1 results)