Development of novel biomarker assay system for severe dengue virus infection.
Project/Area Number |
23659508
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
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Research Institution | Nagasaki University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 感染症 / 重症化予測 / バイオマーカー / デング出血熱 / 免疫測定 / 国際情報交換 / 国際感染症学 |
Research Abstract |
Dengue hemorrhagic fever, a severe sequela of dengue virus infection is a life-threatening condition unless proper treatments are not applied. In the present study, a commercially-available portable SPR device SPR01 (Optoquest, Ageo, Japan) was used for development of rapid quantitative assay of biomarkers for dengue hemorrhagic fever. Dengue virus non-structural protein NS1 and two chemokines, IP10 and CCL3 (MIP-1 alpha) were selected as candidates for such biomarkers. Quantitative assays for dengue virus NS1, IP10 and CCL3 were successfully designed and applied to plasma samples collected in hospitals in Ho Chi Minh City, Vietnam, for the evaluation of its usefulness.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] HLA-B*35:05 is a protective allele with a unique structure among HIV-1 CRF01_AE-infected Thais, in whom the B*57 frequency is low.2014
Author(s)
Mori M, Wichukchinda N, Miyahara R, Rojanawiwat A, Pathipvanich P, Maekawa T, Miura T, Goulder P, Yasunami M, Ariyoshi K, Sawanpanyalert P.
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Journal Title
AIDS
Volume: 28
Issue: 7
Pages: 959-967
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel high-throughput method for molecular serotyping and serotype-specific quantification of Streptococcus pneumoniae using a nanofluidic real-time PCR system.2014
Author(s)
Dhoubhadel BG, Yasunami M, Yoshida LM, Thi HA, Thi TH, Thi TA, Watanabe K, Suzuki M, Morimoto K, Dang DA, Ariyoshi K.
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Journal Title
J Med Microbiol.
Volume: 63
Issue: 4
Pages: 528-539
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] HLA-DP gene polymorphisms and hepatitis B infection in the Japanese population.2012
Author(s)
Migita K, Abiru S, Ohtani M, Jiuchi Y, Maeda Y, Bae SK, Bekki S, Hashimoto S, Yesmembetov K, Nagaoka S, Nakamura M, Komori A, Ichikawa T, Nakao K, Yatsuhashi H, Ishibashi H, Yasunami M.
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Journal Title
Transl Res.
Volume: 160
Issue: 6
Pages: 443-444
DOI
Related Report
Peer Reviewed
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[Presentation] Nha Trang Birth Cohort Study ---A Prospective Study for the Identification of Risk Factors for Childhood Infection/Infectious Diseases2014
Author(s)
Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Vu Dinh Thiem,Trinh Xuan Mai, Bui Trong Chien, Dang Duc Anh, Le Huu Tho, Hiroyuki Moriuchi, Koya Ariyoshi
Organizer
Asian-African Research Forum on Emerging and Reemerging Infections - 2014
Place of Presentation
Sendai, Japan
Related Report
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[Presentation] Nha Trang Birth Cohort Study --- a prospective study for the identification of risk factors for childhood infection/infectious diseases.2014
Author(s)
Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Vu Dinh Thiem, Trinh Xuan Mai, Bui Trong Chien, Dang Duc Anh, Le Huu Tho, Masami Miyakawa, Hiroyuki Moriuchi, Koya Ariyoshi.
Organizer
Asian-African Research Forum on Emerging and Reemerging Infections - 2014.
Place of Presentation
Sendai International Center, Sendai
Related Report
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[Presentation] A birth cohort study revealed that the susceptibility to acute lower respiratory infection was associated with TLR10-TLR1-TLR6 polymorphisms2013
Author(s)
Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Trinh Xuan Mai, Bui Trong Chien, Vu Dinh Thiem, Le Huu Tho, Dang Duc Anh, Koya Ariyoshi
Organizer
日本免疫学会総会
Place of Presentation
幕張
Related Report
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[Presentation] Nha Trang Birth Cohort Study : a population-based study for the identification of phenotype expression of genetic risk factors for childhood infectious diseases in Vietnam2013
Author(s)
Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Vu Dinh Thiem, Trinh Xuan Mai, Bui Trong Chien, Dang Duc Anh, Le Huu Tho, Koya Ariyoshi
Organizer
The American Society of Human Genetics 63rd Annual Meeting
Place of Presentation
Boston, USA
Related Report
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[Presentation] A birth cohort study revealed that the susceptibility to acute lower respiratory infection was associated with TLR10-TLR1-TLR6 polymorphisms.2013
Author(s)
Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Trinh Xuan Mai, Bui Trong Chien, Vu Dinh Thiem, Le Huu Tho, Dang Duc Anh, Koya Ariyoshi.
Organizer
日本免疫学会総会
Place of Presentation
幕張メッセ、千葉
Related Report
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[Presentation] Nha Trang Birth Cohort Study: a population-based study for the identification of phenotype expression of genetic risk factors for childhood infectious diseases in Vietnam.2013
Author(s)
Michio Yasunami, Reiko Miyahara, Lay-Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Vu Dinh Thiem, Trinh Xuan Mai, Bui Trong Chien, Dang Duc Anh, Le Huu Tho, Koya Ariyoshi.
Organizer
The American Society of Human Genetics 63rd Annual Meeting.
Place of Presentation
Boston Convention & Exhibition Center, Boston, USA
Related Report
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[Presentation] A Challenge to Clarify to What Extent the Human Genetic Variations Determine the Risk for Childhood Infection and Infectious Diseases---the NhaTrang Birth Cohort Study2012
Author(s)
Michio Yasunami, Reiko Miyahara, Lay Myint Yoshida, Hitomi Nakamura, Kensuke Takahashi, Vu Thi Que Huong, Trinh Xuan Mai, Vu Dinh Thiem, Le Huu Tho, Dang Duc Anh, Hiroyuki Moriuchi and Koya Ariyoshi
Organizer
NhaTrang Birth Cohort Symposium
Place of Presentation
NhaTrang, Vietnam
Year and Date
2012-11-28
Related Report
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[Presentation] “A Challenge to Clarify to What Extent the Human Genetic Variations Determine the Risk for Childhood Infection and Infectious Diseases---the Nha Trang Birth Cohort Study”2012
Author(s)
Yasunami M, Miyahara R, Yoshida LM, Nakamura H, Takahashi K, Vu TQH, Trinh XM, Vu DT, Le HT, Dang DA, Moriuchi H, Ariyoshi K.
Organizer
Nha Trang Birth Cohort Symposium
Place of Presentation
Nha Trang, Vietnam
Related Report
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