Analysis of glucose intolerance in Ataxia Telangiectasia

• Project/Area Number: 23659517
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TAKAGI Masatoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (10406267)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 小児腫瘍学 / T細胞受容体 / VDJ再構成 / ATM / 脂肪細胞分化 / microRNA

Research Abstract

Ataxia Telangiectasia derived cell exhibited defective adipocyte differentiationmachinery. Involvement of transcription factors such as C/EBPα and PPARγisknown to regulate adipocyte differentiation. In this research, we identified micro RNAscontributes adipocyte differentiation, and defective differentiation was results ofmicroRNAs dysregulation by ATM. Especially, over expression on mir-B in ATMdefective cell attenuated adipocyte differentiation.